Results 11 to 20 of about 330,598 (225)

Circulating hypergranular neoplastic cells: not always leukemic promyelocytes [PDF]

Blood, 2017
![Figure][1] A 39-year-old woman presented with severe low back pain, hepatosplenomegaly, leukocytosis (15.9 × 109/L), anemia (7.3 g/dL), thrombocytopenia (48 × 109/L), and elevated serum tryptase (>200 ng/mL). Coagulation was normal.
Concepción Prats-Martín, Rosario M. Morales-Camacho   +1 more
openaire   +3 more sources

Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphoma [PDF]

Blood, 2019
Iyer and colleagues used deep sequencing of T-cell receptor genes to demonstrate clonal heterogeneity of mycosis fungoides, with repeated seeding of disparate clones from the blood.
Aishwarya Iyer, Weiwei Wang, Dylan Hennessey, Jordan Patterson, Gane Ka-Shu Wong, Robert Gniadecki, Robert Gniadecki, Sandra O'Keefe   +7 more
openaire   +6 more sources

Detection of neoplastic-immune hybrid cells with metastatic properties in uveal melanoma

Research Square, 2023
Background Uveal melanoma is the most common non-cutaneous melanoma and is an intraocular malignancy affecting nearly 7,000 individuals per year worldwide.
Ashley N. Anderson, P. Conley, Christopher Klocke, Sidharth K. Sengupta, Amara Pang, Hannah C. Farley, Abigail R. Gillingham, Aubrey D. Dawson, Yichen Fan, Jocelyn A. Jones, Summer L. Gibbs, Alison H. Skalet, Guanming Wu, Melissa H. Wong   +13 more
semanticscholar   +1 more source

MinimuMM-seq: Genome sequencing of circulating tumor cells for minimally invasive molecular characterization of multiple myeloma pathology.

Cancer Discovery, 2022
Multiple Myeloma (MM) develops from well-defined precursor stages, however, invasive bone marrow (BM) biopsy limits screening and monitoring strategies for patients. We enumerated circulating tumor cells (CTCs) from 261 patients (84 MGUS, 155 SMM, and 22
Ankit K. Dutta, Jean-Baptiste Alberge, Elizabeth D Lightbody, Cody J Boehner, Andrew J. Dunford, Romanos Sklavenitis-Pistofidis, T. Mouhieddine, Annie N. Cowan, N. Su, E. Horowitz, Hadley Barr, Laura Hevenor, Jenna B Beckwith, Jacqueline Perry, Amanda Cao, Ziao Lin, F. Kuhr, R. D. Del Mastro, Omar Nadeem, P. Greipp, C. Stewart, D. Auclair, G. Getz, I. Ghobrial   +23 more
semanticscholar   +1 more source

Comprehensive Atlas of Circulating Rare Cells Detected by SE-iFISH and Image Scanning Platform in Patients With Various Diseases

Frontiers in Oncology, 2022
Objective Circulating rare cells (CRCs) are known as a crucial nucleated cellular response to pathological conditions, yet the landscape of cell types across a wide variety of diseases lacks comprehensive understanding.
Binjie Hu, Yanping Gong, Yulan Wang, Jianzhu Xie, Jin Cheng, Qian Huang   +5 more
semanticscholar   +1 more source

Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors

Scientific Reports, 2021
Metastatic progression defines the final stages of tumor evolution and underlies the majority of cancer-related deaths. The heterogeneity in disseminated tumor cell populations capable of seeding and growing in distant organ sites contributes to the ...
Matthew S. Dietz, T. Sutton, B. Walker, Charles E. Gast, L. Zarour, Sidharth K. Sengupta, John R. Swain, Jennifer Eng, M. Parappilly, K. Limbach, A. Sattler, Erik A. Burlingame, Yu-ichi Chin, Austin Gower, Jose L Montoya Mira, Ajay Sapre, Yu-Jui Chiu, D. Clayburgh, Suellen J Pommier, J. Cetnar, Jared M. Fischer, J. Jaboin, Seunggu J. Han, Kellie J. Nazemi, R. Pommier, K. Billingsley, B. Sheppard, V. L. Tsikitis, Alison H. Skalet, S. Mayo, C. Lopez, J. Gray, G. Mills, Zahi I. Mitri, Young Hwan Chang, K. Chin, M. Wong   +36 more
semanticscholar   +1 more source

In vitro cultures of circulating tumor cells: a potential tool to unravel drug sensitivity

Cancer Drug Resistance, 2022
Since taking part as leading actors in driving the metastatic process, circulating tumor cells (CTCs) have displayed a wide range of potential applications in the cancer-related research field. Besides their well-proved prognostic value, the role of CTCs
G. De Renzi, Giulia De Marco, M. De Meo, Eleonora Del Rosso, P. Gazzaniga, C. Nicolazzo   +5 more
semanticscholar   +1 more source

RNU6-1 in circulating exosomes differentiates GBM from non-neoplastic brain lesions and PCNSL but not from brain metastases

Neuro-Oncology Advances, 2020
Background Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Circulating biomarkers may assist in the processes of differential diagnosis and response assessment.
M. Puigdelloses, M. Gonzalez-Huarriz, M. García-Moure, Naiara Martínez-Vélez, I. Esparragosa Vazquez, J. Bruna, B. Zandio, A. Agirre, M. Marigil, G. Petrirena, J. Núñez-Córdoba, S. Tejada-Solís, R. Díez-Valle, J. Gãllego-Culleré, E. Martı́nez-Vila, A. Patiño-García, M. Alonso, J. Gállego Pérez-Larraya   +17 more
semanticscholar   +1 more source

Natural Killer Cells from the Subcutaneous Adipose Tissue Underexpress the NKp30 and NKp44 in Obese Persons and Are Less Active against Major Histocompatibility Complex Class I Non-Expressing Neoplastic Cells

Frontiers in Immunology, 2017
There are many types of leukocytes reside in subcutaneous adipose tissue (SAT), and among them, natural killer cells (NKs) comprise a major part. We show that the NKs that reside in the SAT (adipose tissue-derived NK cells; ADNKs) of the abdominal region
Alireza Shoae-Hassani, M. Behfar, S. A. Mortazavi-Tabatabaei, J. Ai, R. Mohseni, A. Hamidieh   +5 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source