The Neoplasia as embryological phenomenon and its implication in the animal evolution and the origin of cancer. III. The role of flagellated cell fusion in the formation of the first animal and evolutionary clues to the Warburg effect [PDF]
arXiv, 2022 Cytasters have been underestimated in terms of their potential relevance to embryonic development and evolution. From the perspective discussed herein, structures such as the multiciliated cells of comb rows and balancers supporting mineralized statoliths and macrocilia in Beroe ovata point to a past event of multiflagellate fusion in the origin of ...
arxiv
CXCR6, a Newly Defined Biomarker of Tissue-Specific Stem Cell Asymmetric Self-Renewal, Identifies More Aggressive Human Melanoma Cancer Stem Cells [PDF]
PLoS ONE 5(12): e15183, 2010, 2013 Background: A fundamental problem in cancer research is identifying the cell type that is capable of sustaining neoplastic growth and its origin from normal tissue cells. Recent investigations of a variety of tumor types have shown that phenotypically identifiable and isolable subfractions of cells possess the tumor-forming ability.
arxiv +1 more source
Role of distinct natural killer cell subsets in anticancer response [PDF]
, 2017 Natural killer (NK) cells, the prototypic member of innate lymphoid cells, are important effectors of anticancer immune response. These cells can survey and control tumor initiation due to their capability to recognize and kill malignant cells and to ...
Fionda, Cinzia° +4 more
core +1 more source
Prognostic Value of Multiple Reverse Transcription-PCR Tyrosinase Testing for Circulating Neoplastic Cells in Malignant Melanoma [PDF]
Clinical Chemistry, 2003 Abstract Background: The reverse transcription-PCR tyrosinase assay (TYR test) cannot reliably detect malignant melanoma (MM) cells in blood as the cells often circulate at low concentrations. We evaluated the prognostic value of multiple TYR testing, the prognostic significance of individual positive TYR test results (TYR+) in ...
Piotr Rutkowski +11 more
openaire +3 more sources
Differential Diagnoses of Systemic Mastocytosis in Routinely Processed Bone Marrow Biopsy Specimens: A Review [PDF]
, 2010 Diagnosis of systemic mastocytosis (SM) is mainly based on the morphological demonstration of compact mast cell infiltrates in various tissue sites. In almost all patients such infiltrates are detected in the bone marrow.
Horny, H. -P., Sotlar, K., Valent, P.
core +1 more source
The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients [PDF]
, 2018 Background: Preoperative chemoradiotherapy (CRT) followed by surgery is the standard care for locally advanced rectal cancer, but tumour response to CRT and disease outcome are variable.
A Celeghin +62 more
core +1 more source
Prolactin and its receptor as therapeutic targets in glioblastoma multiforme [PDF]
, 2019 Although prolactin (PRL) and its receptor (PRLR) have been detected in glioblastoma multiforme (GBM), their role in its pathogenesis remains unclear. Our aim was to explore their contribution in GBM pathogenesis.
Abt, Araceli +13 more
core +1 more source
Segmentation of the veterinary cytological images for fast neoplastic tumors diagnosis [PDF]
arXiv, 2023 This paper shows the machine learning system which performs instance segmentation of cytological images in veterinary medicine. Eleven cell types were used directly and indirectly in the experiments, including damaged and unrecognized categories. The deep learning models employed in the system achieve a high score of average precision and recall ...
arxiv
Circulating neuregulin-1 and galectin-3 can be prognostic markers in breast cancer [PDF]
, 2017 Background: It is important to identify novel plasmatic biomarkers that can contribute to assessing the prognosis and outcome of breast cancer patients.
Cardelli, Patrizia +5 more
core +1 more source
Immunological backbone of uveal melanoma: is there a rationale for immunotherapy? [PDF]
, 2019 No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors.
Alessandra Cassano +24 more
core +1 more source