Results 31 to 40 of about 432,951 (336)

Mesenchymal Stem Cell-Derived Antimicrobial Peptides as Potential Anti-Neoplastic Agents: New Insight into Anticancer Mechanisms of Stem Cells and Exosomes

Frontiers in Cell and Developmental Biology, 2022
Mesenchymal stem cells (MSCs), as adult multipotent cells, possess considerable regenerative and anti-neoplastic effects, from inducing apoptosis in the cancer cells to reducing multidrug resistance that bring them up as an appropriate alternative for ...
Kasra Moeinabadi-Bidgoli, Kasra Moeinabadi-Bidgoli, Malihe Rezaee, Malihe Rezaee, Hamidreza Rismanchi, Mohaddese Malek Mohammadi, Amirhesam Babajani   +6 more
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Inducers of epithelial mesenchymal transition and cancer stem cells in malignant pleural effusions [PDF]

, 2016
The Epithelial to Mesenchymal Transition (EMT) plays a role not only in tumor metastasis but also in tumor recurrence. This process is believed to be tightly linked to the presence of Cancer Stem Cells (CSCs) however, it is still not clear which ...
Cherubini, Emanuela, Giarnieri, Enrico, Giovagnoli, Maria Rosaria, Mancini, Rita, Mariotta, Salvatore, Ricci, Alberto   +5 more
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Evolution of normal and neoplastic tissue stem cells: progress after Robert Hooke [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2015
The appearance of stem cells coincides with the transition from single-celled organisms to metazoans. Stem cells are capable of self-renewal as well as differentiation. Each tissue is maintained by self-renewing tissue-specific stem cells. The accumulation of mutations that lead to preleukaemia are in the blood-forming stem cell, while the transition ...
Irving L. Weissman
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Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis [PDF]

Blood, 2020
Abstract The KIT D816V mutation is found in >80% of patients with systemic mastocytosis (SM) and is key to neoplastic mast cell (MC) expansion and accumulation in affected organs. Therefore, KIT D816V represents a prime therapeutic target for SM.
Marcelo A. S. Toledo, Malrun Gatz, Stephanie Sontag, Karoline V. Gleixner, Gregor Eisenwort, Kristina Feldberg, Ahmed E.I. Hamouda, Frederick Kluge, Riccardo Guareschi, Giulia Rossetti, Antonio Sechi, Olli Dufva, Satu Mustjoki, Angela Maurer, Herdit M. Schüler, Roman Goetzke, Till Braunschweig, Anne Kaiser, Jens Panse, Mohamad Jawhar, Andreas Reiter, Frank Hilberg, Peter Ettmayer, Wolfgang Wagner, Steffen Koschmieder, Tim H. Brümmendorf, Peter Valent, Nicolas Chatain, Martin Zenke   +28 more
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Neoplastic stem cells: A novel therapeutic target in clinical oncology [PDF]

Cancer, 2006
AbstractCancer is among the leading causes of morbidity and mortality in the Western world. Despite recent advances, most therapeutic approaches fail to eradicate the entire neoplastic clone. The remaining cells often develop metastasis and/or recurrences and therefore may represent attractive targets of therapy.
Axel, Schulenburg, Herbert, Ulrich-Pur, Dietmar, Thurnher, Boban, Erovic, Stefan, Florian, Wolfgang R, Sperr, Peter, Kalhs, Brigitte, Marian, Friedrich, Wrba, Christoph C, Zielinski, Peter, Valent   +10 more
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Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas [PDF]

, 2019
The bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin. Consequently, preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular ...
Alvaro, D, Arcidiacono, Pg, Capurso, G., Cardinale, V, Carpino, G, Doglioni, C, Gaudio, E, Pedica, F, Petrone, Mc, Severi, C, Zaccari, P   +10 more
core   +1 more source

Natural Killer Cells: Diverse Functions in Tumor Immunity and Defects in Pre-neoplastic and Neoplastic Stages of Tumorigenesis

Molecular Therapy: Oncolytics, 2020
Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and secreted or membrane-bound interferon (IFN)-γ and tumor ...
Anahid Jewett, Janko Kos, Kawaljit Kaur, Tahmineh Safaei, Christine Sutanto, Wuyang Chen, Paul Wong, Artin Keshishian Namagerdi, Changge Fang, Yuman Fong, Meng-Wei Ko   +10 more
doaj   +1 more source

Posttransplant lymphoproliferative disorders in neuronal xenotransplanted macaques [PDF]

, 2016
Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of lymphoid proliferations that occur in the setting of depressed T-cell function due to immunosuppressive therapy used following solid organ transplantation, hematopoietic ...
Aron Badin, R., Cavicchioli, L., Cozzi, E., Crossan, C., Danesi, A., Ferraresso, S., Hantraye, P., Kaliyaperumal, S., Knight, H., Scobie, L., Trez, D., Vadori, M., Westmoreland, S.   +12 more
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Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation [PDF]

Nature, 2008
Cancer stem cells are remarkably similar to normal stem cells: both self-renew, are multipotent and express common surface markers, for example, prominin 1 (PROM1, also called CD133). What remains unclear is whether cancer stem cells are the direct progeny of mutated stem cells or more mature cells that reacquire stem cell properties during tumour ...
Liqin Zhu, Paul Gibson, D. Spencer Currle, Yiai Tong, Robert J. Richardson, Ildar T. Bayazitov, Helen Poppleton, Stanislav S. Zakharenko, David W. Ellison, Richard J. Gilbertson   +9 more
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Cellullar Plasticity and Dedifferentiation: A Link Between Cancer Stem Cells, Hypoxia, Cell Injury, and Inflammation

Journal of Stem Cell Research and Tissue Engineering, 2019
Cellular plasticity is the concept of bidirectional dynamics change cells differentiation degree which involved in the regeneration, repair and tissue turnover along the organism livespan.
Andi Yasmin Wijaya
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