Results 51 to 60 of about 417,028 (237)

Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]

, 2018
Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core   +1 more source

Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate [PDF]

Oncotarget, 2017
Mesenchymal Stem Cells (MSCs) have been identified in prostate cancer, raising the critical question of their physical and temporal source. Therefore, MSCs were quantified and characterized in benign and malignant prostate tissue representing different disease states and a wide range of age groups from fetal development through adult death using ...
L. Nelleke Kisteman, Angelo M. De Marzo, Angelo M. De Marzo, Alan K. Meeker, Alan K. Meeker, W. Nathaniel Brennen, John T. Isaacs, John T. Isaacs, Ibrahim Kulac, Isla P. Garraway, Samuel R. Denmeade, Samuel R. Denmeade, Baohui Zhang, Lizamma Antony, Hao Wang   +14 more
openaire   +5 more sources

Combined TGF-β3 and FGF-2 Stimulation Enhances Chondrogenic Potential of Ovine Bone Marrow-Derived MSCs

Cells
Mesenchymal stem cells (MSCs) represent a promising cell source for cartilage tissue engineering due to their chondrogenic potential. However, current differentiation protocols result in limited efficiency.
Sandra Stamnitz, Agnieszka Krawczenko, Aleksandra Klimczak   +2 more
doaj   +1 more source

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma.

Frontiers in Physiology, 2013
Background: CD133 has been identified as a cancer stem cell (CSC) marker for pancreatic ductal adenocarcinoma. Although leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5), a marker of intestinal stem cells, has been shown to be on a ...
Nobumasa eMizuno, Yasushi eYatabe, Kazuo eHara, Susumu eHijioka, Hiroshi eImaoka, Yasuhiro eShimizu, Shigeru B.H. Ko, Kenji eYamao   +7 more
doaj   +1 more source

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation [PDF]

Nature, 2008
Cancer stem cells are remarkably similar to normal stem cells: both self-renew, are multipotent and express common surface markers, for example, prominin 1 (PROM1, also called CD133). What remains unclear is whether cancer stem cells are the direct progeny of mutated stem cells or more mature cells that reacquire stem cell properties during tumour ...
Helen Poppleton, D. Spencer Currle, Robert J. Richardson, Richard J. Gilbertson, Paul Gibson, Liqin Zhu, Stanislav S. Zakharenko, David W. Ellison, Yiai Tong, Ildar T. Bayazitov   +9 more
openaire   +3 more sources

Stromal CD10 expression in breast cancer correlates with tumor invasion and cancer stem cell phenotype

BMC Cancer, 2018
Background Previous investigations have indicated that CD10 is associated with biological aggressivity in human cancers, but the use of this marker for diagnosis and prognosis is more complex.
Tahani Louhichi, Hanene Saad, Myriam Ben Dhiab, Sonia Ziadi, Mounir Trimeche   +4 more
doaj   +1 more source

Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells [PDF]

, 2015
The final published version can be found here: http://dx.doi.org/10.1073/pnas ...
Anna Karlsson, Choksi, Deli A, Jayeta Saxena, Joanne Betts, Kiebish, Kim, L. Miguel Martins, Melania Capasso, Nick V. Henriquez, Paolo Salomoni, Pierluigi Nicotera, Sara Galavotti, Schwartzbaum, Sebastian Brandner, Stefano Bartesaghi, Valentina Minieri, Vincenzo De Laurenzi, Vincenzo Graziano   +18 more
core   +1 more source

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state [PDF]

Proceedings of the National Academy of Sciences, 2011
Current models of stem cell biology assume that normal and neoplastic stem cells reside at the apices of hierarchies and differentiate into nonstem progeny in a unidirectional manner. Here we identify a subpopulation of basal-like human mammary epithelial cells that departs from that assumption, spontaneously dedifferentiating into stem-like cells ...
Christine L. Chaffer, Ines Brueckmann, Christina Scheel, Alicia J. Kaestli, Paul A. Wiggins, Leonardo O. Rodrigues, Mary W. Brooks, Ferenc Reinhardt, Ying Su, Kornélia Polyák, Lisa M. Arendt, Charlotte Kuperwasser, Brian Bierie, Robert A. Weinberg   +13 more
openalex   +5 more sources

Paracrine signaling in stem cell renewal and in neoplastic tumor growth [PDF]

Science China Life Sciences, 2014
Paracrine pathway activities are being increasingly recognized as instrumental regulatory mechanisms of epithelial-stromal interactions that play important roles in physiological and pathological self-renewal of stem cells and in the initiation and maintenance of neoplastic tumor development.
openaire   +3 more sources

Mesenchymal stem cells as all-round supporters in a normal and neoplastic microenvironment [PDF]

Cell Communication and Signaling, 2012
Mesenchymal stem cells (MSC) represent a heterogeneous population exhibiting stem cell-like properties which are distributed almost ubiquitously among perivascular niches of various human tissues and organs. Organismal requirements such as tissue damage determine interdisciplinary functions of resident MSC including self-renewal, migration and ...
Ralf Hass, Anna Otte
openaire   +4 more sources