Results 101 to 110 of about 304,509 (373)
Stress-Induced Mutagenesis Can Further Boost Population Success in Static Ecology [PDF]
arXiv, 2023 We have developed a mathematical model that captures stress-induced mutagenesis, a fundamental aspect of pathogenic and neoplastic evolutionary dynamics, on the fitness landscape with multiple relevant genetic traits as a high-dimensional Euclidean space. In this framework, stress-induced mutagenesis manifests as a heterogeneous diffusion process.
arxiv
Advanced Science, EarlyView.Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen +11 more
wiley +1 more source
Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. [PDF]
, 2015 BackgroundThe mammary glands of pigs share many functional and morphological similarities with the breasts of humans, raising the potential of their utility for research into the mechanisms underlying normal mammary function and breast carcinogenesis ...
Borowsky, AD +5 more
core
A preclinical model for the ATLL lymphoma subtype with insights into the role of microenvironment in HTLV-1-mediated lymphomagenesis [PDF]
, 2018 \uef7f View references (83) Adult T cell Leukemia/Lymphoma (ATLL) is a mature T cell malignancy associated with Human T cell Leukemia Virus type 1 (HTLV-1) infection.
Adriana Mattiolo +8 more
core +2 more sources
EMBO Molecular Medicine, 2013 Initiating neoplastic cell transformation events are of paramount importance for the comprehension of regeneration and vanguard oncogenic processes but are difficult to characterize and frequently clinically overlooked.
Gonçalo Regalo, Achim Leutz
doaj +1 more source
MicroRNAs involved in neoplastic transformation of liver cancer stem cells
Journal of Experimental & Clinical Cancer Research, 2010 Background The existence of cancer stem cells in hepatocellular carcinoma (HCC) has been verified by characterizing side population (SP) cells based on efflux of Hoechst 33342 dye from stem cells. Recent advances in microRNA (miRNA) biology have revealed
Wang Xinchuan +5 more
doaj +1 more source
Advanced Science, EarlyView.STMIGCL is an implicit contrastive learning‐based multi‐view graph convolutional network framework designed for downstream tasks such as spatial domain recognition, trajectory inference, and spatially variable gene identification. By combining multi‐view learning with contrastive learning and employing contrastive learning methods that enhance contrast
Sheng Ren +5 more
wiley +1 more source
Expression of platelet-derived growth factor-beta receptor and bovine papillomavirus E5 and E7 oncoproteins in equine sarcoid. [PDF]
, 2008 Equine sarcoids are benign fibroblastic skin tumours that are recognized throughout the world. Infection with bovine papillomavirus (BPV) types 1 and 2 has been implicated as a major factor in disease development; however, the cellular mechanisms ...
BORZACCHIELLO, GIUSEPPE +4 more
core
Non-linear relationship of cell hit and transformation probabilities in a low dose of inhaled radon progenies [PDF]
, 2009 Cellular hit probabilities of alpha particles emitted by inhaled radon progenies in sensitive bronchial epithelial cell nuclei were simulated at low exposure levels to obtain useful data for the rejection or support of the linear-non-threshold (LNT ...
Balásházy, Imre +3 more
core +2 more sources
Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration
Advanced Science, EarlyView.The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan +16 more
wiley +1 more source