Results 141 to 150 of about 1,988,958 (283)

Impact of the pancreatic enzyme replacement therapy (PERT) shortage on prescribing in England: Analysis of national data

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Pancreatic enzyme replacement therapy (PERT) is essential for the management of pancreatic exocrine insufficiency. Since June 2023, the United Kingdom has been affected by a global shortage of PERT. We investigated the impact of this shortage on national prescribing trends for Creon, Nutrizym, Pancrex and Pangrol.
Teena S. Varghese   +6 more
wiley   +1 more source

Role of Repair Processes in Neoplastic Transformation Induced by Ionizing Radiation in C3H/10T1/2 Cells [PDF]

open access: yes, 1984
The paper discusses the mechanisms underlying the induction and modulation of neoplastic transformation by the type and mode of radiation delivery. Those features of transformation in vitro characteristic of induction by ionizing radiation are described.
Hill, C. K., Elkind, M. M., Han, A.
core  

The tumour suppressor CCDC6 is involved in ROS tolerance and neoplastic transformation by evading ferroptosis. [PDF]

open access: yesHeliyon, 2021
Morra F   +6 more
europepmc   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

open access: yesBMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim   +9 more
wiley   +1 more source

Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity

open access: yesEpigenetics & Chromatin
Background It is generally accepted that methylation status of CpG sites spaced up to 50 bp apart is correlated, and accumulation of locally disordered methylation at adjacent CpG sites is involved in neoplastic transformation, acting in similar way as ...
Olga Taryma-Leśniak   +5 more
doaj   +1 more source

A case series of necrotizing periodontal diseases in hospitalized patients: What hasn't been said yet?

open access: yesClinical Advances in Periodontics, EarlyView.
Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal   +8 more
wiley   +1 more source

Braf mutation induces rapid neoplastic transformation in the aged and aberrantly methylated intestinal epithelium. [PDF]

open access: yesGut, 2022
Fennell L   +9 more
europepmc   +1 more source

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