Results 151 to 160 of about 1,988,958 (283)

The dose rate dependence of oncogenic transformation by neutrons may be due to variation of response during the cell cycle [PDF]

, 1986
Rossi, H. H., Kellerer, Albrecht M.
core   +1 more source

Genomics define neoplastic transformation in multiple myeloma precursor conditions

Background: Multiple myeloma (MM) is always preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). While these precursor conditions are asymptomatic, they are not entirely benign and carry a lifelong ...
Castellano, Giancarlo, de Magistris, Claudio, Siegel, Erin, Leongamornlert, Daniel, Teer, Jamie, Shain, Kenneth, Ziccheddu, Bachisio, Marella, Alessio, Baz, Rachid, McPherson, Andrew, Garces, Juan-Jose, Deavila, Daniel, Morgan, Gareth, Derkach, Andriy, Sudalagunta, Praneeth Reddy, Diamond, Benjamin, Campbell, Peter, Agius, Phaedra, Durante, Michael, Renatino Canevarolo, Rafael, Blaney, Patrick, Yamashita, Yusuke, Papadimitriou, Marios, Kumar, Shaji, Maeda, Akihiro, Fonseca, Rafael, Hultcrantz, Malin, Siqueira Silva, Ariosto, Landgren, Ola, Orlowski, Robert, Braggio, Esteban, Pioggia, Stefania, Rajkumar, Vincent, Matera, Antonio, Maura, Francesco, Asmann, Yan, Lionetti, Marta, Usmani, Saad, Da Vià, Matteo Claudio, Patel, Krina, Bergsagel, P. Leif, Firestone, Ross, Bolli, Niccolo, Maclachlan, Kylee   +43 more
core   +1 more source

Opsoclonus in Pediatric Patients: Differential Diagnosis and a Practical Approach to Evaluation

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Opsoclonus is an ocular dyskinesia characterized by involuntary, arrhythmic, multidirectional saccades. In pediatrics, opsoclonus is most commonly attributed to the rare neuroinflammatory disorder opsoclonus‐myoclonus‐ataxia syndrome (OMAS), typically considered a paraneoplastic syndrome associated with neural crest tumors. However, opsoclonus
Aubrey C. Reed, Supreet S. Randhawa, Jason H. Peragallo, Prabhumallikarjun Patil, Grace Gombolay, Varun Kannan   +5 more
wiley   +1 more source

Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma. [PDF]

Mol Cell, 2022
Deforzh E, Uhlmann EJ, Das E, Galitsyna A, Arora R, Saravanan H, Rabinovsky R, Wirawan AD, Teplyuk NM, El Fatimy R, Perumalla S, Jairam A, Wei Z, Mirny L, Krichevsky AM.   +14 more
europepmc   +1 more source

A Robust Computational Workflow Utilizing Generalized Least Squares (GLS) and Generalized Estimating Equations (GEE‐GLM) for Longitudinal Flow Cytometry Maturation Data Analysis

Cytometry Part A, EarlyView.
ABSTRACT Routinely used statistical hypothesis tests are often inadequate for longitudinal flow cytometry data, necessitating more sophisticated modeling approaches. Analyzing dynamic biomarker expression across hematopoietic maturation presents several analytical challenges, notably nonlinearity, serial correlation between subsequent stages, and ...
Sixuan Joanna Wang, Ruben Deneer, Tom Schoenmakers, Stefan G. C. Mestrum, Yvonne M. C. Henskens, Otto Bekers, Anton H. N. Hopman, Frans C. S. Ramaekers, Mathie P. G. Leers   +8 more
wiley   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Circulating monocyte partitioning and its alteration in hematological chronic neoplasms

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Circulating monocyte partitioning refers to the relative quantification of the three main monocyte subsets in the peripheral blood, namely classical (cMo), intermediate (iMo), and non‐classical (ncMo) monocytes, as assessed by flow cytometry, a new nomenclature described 15 years ago.
Sihem Tarfi, Dorothée Selimoglu‐Buet, Ivan Sloma, Orianne Wagner‐Ballon, on behalf of the French group CytHem‐LMMC   +4 more
wiley   +1 more source

Automated B‐cell and plasma cell identification using unsupervised clustering by FlowSOM and an excel‐based classification model

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Manual gating for plasma cell (PC) identification in multiparametric flow cytometry (MFC) is time‐consuming and operator‐dependent, especially when PCs are scarce. Artificial intelligence approaches such as unsupervised clustering (e.g., FlowSOM) map high‐dimensional data that still require expert interpretation.
Ethan James Gantana, Ernest Musekwa, Erica‐Mari Nell, Zivanai Cuthbert Chapanduka   +3 more
wiley   +1 more source

Trp53 loss drives the neoplastic transformation of Pik3caH1047R-induced vascular malformation in a mouse model. [PDF]

PLoS One
Tang M, Sallavanti J, Lanza M, Covington D, Li W.   +4 more
europepmc   +1 more source

Study of the metabolic alterations in patulin-induced neoplastic transformation in normal intestinal cells. [PDF]

Toxicol Res (Camb), 2021
Singh N, Sharma G, Dev I, Shukla SK, Ansari KM.   +4 more
europepmc   +1 more source