Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models [PDF]
Computational and Structural Biotechnology Journal, 2022 Organoid modeling is a powerful, robust and efficient technology faithfully preserving physiological and pathological characteristics of tissues of origin.
Hua Zhao +4 more
doaj +2 more sources
Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation [PDF]
eLife, 2021 Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock +9 more
doaj +2 more sources
Gastric Hyperplastic Polyps: A Benign Entity? Analysis of Recurrence and Neoplastic Transformation in a Cohort Study [PDF]
GE: Portuguese Journal of Gastroenterology, 2021 Introduction: Hyperplastic polyps represent 30–93% of all gastric epithelial polyps. They are generally detected as innocuous incidental findings; however, they have a risk of neoplastic transformation and recurrence.
Mafalda João +7 more
doaj +2 more sources
Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation [PDF]
Nature Communications, 2023 The dysregulation of the m6A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 ...
An Xu +32 more
doaj +2 more sources
Significance of Furin Expression in Thyroid Neoplastic Transformation [PDF]
Cancers, 2023 Angiotensin-Converting Enzyme 2 (ACE2), Transmembrane Serine Protease 2 (TMPRSS2), and Furin were known to be key players in the SARS-CoV-2 infection, and the thyroid gland was revealed to be one of the relevant targets of the virus. Regardless of the viral infection, the expression of these molecules in the thyroid gland and their putative role in the
Maria Teresa Azevedo +8 more
openaire +3 more sources
Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence [PDF]
Scientific Reports, 2021 Much in vivo evidence indicates that cyclooxygenase-2 (COX-2) is deeply involved in tumorigenesis. Although it has been proposed that COX-2-derived pro-inflammatory prostanoids mediate the tumorigenic activity of COX-2, the tumorigenic mechanisms of COX ...
Hyeon Ju Lee +3 more
doaj +2 more sources
Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation [PDF]
Nature Communications, 2021 The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D ...
Roser Vilarrasa-Blasi +19 more
doaj +2 more sources
Radiation-Induced Neoplastic Transformation , Hormesis and Risk Assessment [PDF]
Dose-Response, 2007 Dose-response curves for various low-LET radiation sources have consistently been demonstrated to be J-shaped for the cancer-relevant endpoint of neoplastic transformation in vitro.
J. Leslie Redpath PhD, Eugene Elmore PhD
doaj +2 more sources
Oncogenic FGFR Fusions Produce Centrosome and Cilia Defects by Ectopic Signaling
Cells, 2021 A single primary cilium projects from most vertebrate cells to guide cell fate decisions. A growing list of signaling molecules is found to function through cilia and control ciliogenesis, including the fibroblast growth factor receptors (FGFR). Aberrant
Alexandru Nita +3 more
doaj +1 more source
Adenomatoid Odontogenic Tumour Associated with Dentigerous Cyst: Case Report with Literature Review [PDF]
Journal of Clinical and Diagnostic Research, 2021 Adenomatoid Odontogenic Tumour (AOT) is a relatively uncommon benign odontogenic tumour composed of odontogenic epithelium in a variety of histoarchitectural patterns. Conventional AOT is predominantly seen in females in second decade of life exhibiting
Pradipta Ramgonda Patil +4 more
doaj +1 more source