Results 51 to 60 of about 16,884 (255)

The Effects of Neopterin on the Viability and Motility of Different HCC Cell Lines

Proceedings, 2018
Increased neopterin levels reflect the activation of the cellular immune system which is of importance in the pathogenesis and progression of various diseases such as cancer.
Imge Kunter, Marianna Najjar, Yelin Subasi, Niloofar Zabib, Gonul Sahin   +4 more
doaj   +1 more source

Age‐Associated Expansion of HIV/SIV Reservoirs in People With HIV and SIV‐Infected Macaques

Aging Cell, Volume 24, Issue 12, December 2025.
Virally suppressed older people with HIV have larger peripheral blood CD4+ T‐cell reservoirs than younger individuals, correlating with CD4+ and CD8+ T‐cell activation. Similar results were seen in SIV‐infected, ART‐treated aged rhesus macaques. ABSTRACT With the advancement of combination antiretroviral therapy (ART), over 50% of people with HIV (PWH)
Arpan Acharya, Debapriya Sutar, Mahesh Mohan, Varan Govind, Francois Villinger, Suresh Pallikkuth, Siddappa N. Byrareddy   +6 more
wiley   +1 more source

Plasma total neopterin and neopterin levels are significantly elevated in stroke patients before carotid endarterectomy surgery

Pteridines
Atherosclerosis is an inflammatory disease where activated immune cells are recruited into the artery wall forming artery plaques. Interferon-γ released by T-cells causes macrophage synthesis and release of 7,8-dihydroneopterin, an antioxidant and CD36 ...
Raajasekar Siddarth, Roake Justin, Cameron Vicky, Benson Ruth, Pilbrow Anna, Gieseg Steven   +5 more
doaj   +1 more source

Systemic Immune Activation, Anemia and Thrombocytosis in Breast Cancer Patients Treated by Doxorubicin and Paclitaxel

Pteridines, 2006
Increased urinary concentrations of neopterin, an indicator of systemic immune activation, have been reported only in a minority of patients with breast cancer. We determined urinary neopterin by high-performance liquid chromatography in 78 patients with
Melichar Bohuslav, Solichova Dagmar, Melicharova Karolina, Urminska Hana, Ryska Ales, Cermanova Melanie   +5 more
doaj   +1 more source

Interventions for neurocognitive dysfunction [PDF]

, 2017
Purpose of review: To evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last three years. Recent findings: Optimal anti-retroviral therapy (ART) poses
Brew, B, Ellero, J, Lubomski, M
core   +2 more sources

Efficient Total Syntheses of Natural Neopterin Glycosides: Neopterin Glucronide and Solfapterin [PDF]

HETEROCYCLES, 2017
1’,2’-Di-O-acetyl-N2-(N,N-dimethylaminomethylene)-3-[2-(4-nitro- phenyl)ethyl]neopterin (11a) and its 1’,2’-di-O-benzoyl analog (11b) were prepared from neopterin in 5 steps, respectively. Glycosylation of 11a with methyl 2,3,4-tri-O-benzoyl-α-D-glucopyranosyluronate bromide (15b) in the presence of silver triflate afforded the corresponding 3’-O-(β-D ...
Hanaya, Tadashi, Iwasaki, Katsuya, Saeki, Kaori, Hattori, Takafumi   +3 more
openaire   +2 more sources

Evaluating miRNA Sequencing and Integrative Proteomics for Identifying Plasma miRNAs as Potential Pharmacodynamic Biomarkers of IFNβ‐1a Biologics

Clinical and Translational Science, Volume 18, Issue 12, December 2025.
ABSTRACT We used miRNA sequencing to identify candidate plasma pharmacodynamic (PD) biomarkers of interferon beta‐1a (IFNβ‐1a) biologics and explored miRNA‐mRNA targeted protein relationships and networks to support identified miRNA candidates. Plasma samples from 36 healthy subjects from a placebo‐controlled randomized single‐dose clinical study with ...
Mai Mehanna, Lakshmi Manasa Chekka, Barry A. Rosenzweig, Deepti P. Samarth, Esraa G. Mohamed, Isaac Raplee, Catherine Sullenberger, Erica Decker, Sarah J. Schrieber, Yow‐Ming Wang, Jeffry Florian, Paula L. Hyland   +11 more
wiley   +1 more source

Influence of Three Different Diet Modes Combined with Exercise Loads on Urinary and Plasma Neopterin Concentrations: A Longitudinal Study

Pteridines, 1997
During six months, we studied the influence of three extremely different diet modes (normal diet, carbohydrate- rich diet, fat-rich diet) combined with three defined exercise loads (step test, endurance test fo r 30 minutes, endurance test for 90 minutes)
Lamprecht Manfred, Mlekusch Walter, Vrecko Karoline, Reibnegger Gilbert   +3 more
doaj   +1 more source

Neopterin Counters Vascular Inflammation and Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundNeopterin, a metabolite of GTP, is produced by activated macrophages and is abundantly expressed within atherosclerotic lesions in human aorta and carotid and coronary arteries.
Remina Shirai, Kengo Sato, Tomoyuki Yamashita, Maho Yamaguchi, Taisuke Okano, Kaho Watanabe‐Kominato, Rena Watanabe, Taka‐aki Matsuyama, Hatsue Ishibashi‐Ueda, Shinji Koba, Youichi Kobayashi, Tsutomu Hirano, Takuya Watanabe   +12 more
doaj   +1 more source

Low‐dose total skin electron beam therapy in erythrodermic mycosis fungoides and Sézary syndrome: Results From the Prospective S‐MISR Study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 12, Page 1534-1542, December 2025.
Summary Background Erythrodermic mycosis fungoides (eMF) and Sézary syndrome (SS) often show delayed and non‐durable clinical responses to systemic therapies. Patients and Methods A total of 35 patients with eMF or SS were treated with total skin electron beam therapy (TSEBT).
Khaled Elsayad, Christian Kandler, Jan Jakob Siats, Niklas Pepper, Moritz Fabian Danzer, Gabor Dobos, Elisabeth Livingstone, Susanne Melchers, Johannes Kleemann, Julia Hyun, Claudia Pföhler, Peter von den Driesch, Jan P. Nicolay, Rudolf Stadler, Hans Theodor Eich   +14 more
wiley   +1 more source