Results 71 to 80 of about 16,884 (255)

Clinical Characteristics of Parkinsonism in HTLV‐1‐Associated Myelopathy

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 10, Page 1962-1970, October 2025.
ABSTRACT Objective Human T‐lymphotropic virus type 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the classic neurological manifestation of HTLV‐1 infection; however, this virus has also been associated with other neurological disorders. Concurrent parkinsonism is relatively rare and presents diagnostic challenges.
Mika Dozono   +8 more
wiley   +1 more source

Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience [PDF]

open access: yes, 2018
In every newborn with even mild hyperphenylalaninemia (HPA) tetrahydrobiopterin (BH4) deficiencies need to be excluded as soon as possible. Differential diagnosis is most commonly performed by analysis of urinary neopterin and biopterin.
Abu Seda, Bettina   +5 more
core  

Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]

open access: yes, 2013
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
core   +2 more sources

Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection [PDF]

open access: yes, 2016
OBJECTIVE: To investigate the role of homocysteine in neuronal injury in HIV infection. METHODS: Using a cross-sectional design and archived samples, we compared concentrations of plasma homocysteine and cerebrospinal fluid (CSF) neurofilament light ...
Ahlgren, E   +6 more
core   +6 more sources

Urinary Neopterin in Patients with Ovarian Cancer

open access: yesPteridines, 2006
Urinary neopterin, an indicator of systemic immune activation, is increased in most patients with epithelial ovarian carcinoma (EOC) and is an independent prognostic indicator.
Melichar Bohuslav   +8 more
doaj   +1 more source

A Systematic Review and Meta‐Analysis of the Role of Peripheral Inflammation in Delirium

open access: yesBrain and Behavior, Volume 15, Issue 10, October 2025.
This review found peripheral inflammation is associated with delirium. Preceding delirium, the neutrophil‐to‐lymphocyte ratio (NLR), interleukin‐6 (IL‐6), C‐reactive protein (CRP), and Leukocyte Count(WBC) were higher, and insulin‐like growth factor‐1 (IGF‐1) lower, in those that developed delirium.
Hannah C. Moorey   +4 more
wiley   +1 more source

Serum Neopterin Levels in Lung and Breast Cancer Patients Undergoing Radiotherapy And/Or Chemotherapy

open access: yesThe International Journal of Biological Markers, 1988
The elevated neopterin levels observed in numerous haemotological diseases and parenchymatous malignomas suggested neopter in might be useful as a tumor marker.
G. von Ingersleben   +2 more
doaj   +1 more source

Characterization of Proteomic Pharmacodynamic Biomarkers of IFNβ‐1a Biologics to Inform Potential Utility in Biosimilar Development

open access: yesClinical Pharmacology &Therapeutics, Volume 118, Issue 4, Page 935-945, October 2025.
Pharmacodynamic (PD) biomarkers can support biosimilarity assessment, potentially reducing the need for comparative clinical efficacy studies. This study aimed to characterize previously identified proteomic PD biomarker candidates for Interferon beta‐1a (IFNβ‐1a, n = 248) and pegylated IFNβ‐1a (pegIFNβ‐1a, n = 528) biologics at therapeutic doses, to ...
Lakshmi Manasa S. Chekka   +15 more
wiley   +1 more source

Salivary neopterin concentrations in patients with cancer of the oral cavity

open access: yesPteridines, 2016
Tumors of the oral cavity are relatively common malignancies with a poor prognosis. Use of both prognostic and predictive biomarkers in saliva represents one approach to improve the management of patients with these cancers.
Pink Richard   +5 more
doaj   +1 more source

Inflammation and endothelial function: Direct vascular effects of human C-reactive protein on nitric oxide bioavailability [PDF]

open access: yes, 2005
Background - Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated.
Clapp, BR   +10 more
core   +1 more source

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