A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization
Cell Reports, 2019 Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states.
Paulina M. Wojnarowicz +32 more
doaj +2 more sources
MicroRNA-18a-5p Administration Suppresses Retinal Neovascularization by Targeting FGF1 and HIF1A
Frontiers in Pharmacology, 2020 Pathologic ocular neovascularization commonly results in visual impairment or even blindness in numerous fundus diseases, including proliferative diabetic retinopathy (PDR), retinopathy of prematurity (ROP), and age-related macular degeneration (AMD ...
Ji-Tian Guan +10 more
doaj +2 more sources
FGF2-induced STAT3 activation regulates pathologic neovascularization
Experimental Eye Research, 2019 Cell-autonomous endothelial cell (EC) fibroblast growth factor receptor (FGFR) signaling through FGFR1/2 is essential for injury-induced wound vascularization and pathologic neovascularization as in blinding eye diseases such as age-related macular degeneration. Which FGF ligand(s) is critical in regulating angiogenesis is unknown.
Craig P. Smith +6 more
openaire +4 more sources
Apolipoprotein E2 and E3, but Not E4, Promote Retinal Pathologic Neovascularization
Investigative Opthalmology & Visual Science, 2017 To determine the relationship between the different isoforms of apolipoprotein E (ApoE) and retinal neovascularization.The concentrations of ApoE and VEGF in vitreous humor samples with either a macular hole (MH), or diabetic macular edema (DME), or proliferative diabetic retinopathy (PDR) with or without intravitreal injection of bevacizumab (IVB ...
Atsushi Kojima +9 more
openaire +4 more sources
Oxidative and Nitrosative Stress in Age-Related Macular Degeneration: A Review of Their Role in Different Stages of Disease [PDF]
Antioxidants, 2021 Although the exact pathogenetic mechanisms leading to age-related macular degeneration (AMD) have not been clearly identified, oxidative damage in the retina and choroid due to an imbalance between local oxidants/anti-oxidant systems leading to chronic ...
De Cilla', Stefano +4 more
core +3 more sources
Ocular Risk Factors for Choroidal Neovascularization in Pathologic Myopia
Investigative Opthalmology & Visual Science, 2010 PURPOSE. To identify the risk factors for development of myopic choroidal neovascularization (mCNV), a major cause of visual impairment. METHODS. Enrolled in the study were 23 consecutive patients with bilateral high myopia (axial length, > or =26.5 mm or refractive error, < or =8 D) and unilateral newly developed mCNV who presented to the Myopia ...
Yukari Jo +3 more
openaire +4 more sources
Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading ...
Thaís Heinke +3 more
doaj +3 more sources
Correlation between the expression of vegf and survival in osteosarcoma [PDF]
Acta Ortopédica Brasileira, 2014 Objective: To present a series of 50 consecutive patients with non-metastatic extremity osteosarcoma, and attempt to correlate expression of the vascular endothelial growth factor (VEGF) protein in biopsy tissue to their prognosis regarding overall ...
André Mathias Baptista +5 more
doaj +1 more source
Evaluation of a novel deep learning based screening system for pathologic myopia [PDF]
International Journal of Ophthalmology, 2023 AIM: To evaluate the clinical application value of the artificial intelligence assisted pathologic myopia (PM-AI) diagnosis model based on deep learning. METHODS: A total of 1156 readable color fundus photographs were collected and annotated based on the
Pei-Fang Ren +5 more
doaj +1 more source
Significance of microvessel density in prostate cancer core biopsy [PDF]
Vojnosanitetski Pregled, 2015 Background/Aim. In prostate tumors, angiogenesis, measured as microvessel density, is associated with tumor stage and Gleason score. The aim of this study was determine neovascularization of prostatic adenocarcinomas in core biopsies and ...
Salapura-Dugonjić Aleksandra +3 more
doaj +1 more source