Results 21 to 30 of about 125,954 (295)

Antibody-drug conjugate (Pathologic ocular neovascularization in mouse models)

, 2021
Immunofluorescence staining of whole-mount retinas and retinal pigment epithelium-choroid-scleral complexes, electroretinography, and OptoMotry test were used to evaluate the effect and safety of ADC targeting mPDGFRβ in the mouse models of pathologic ...
Su Ree Kim, Jisu Chae, Seok Jae Lee, Soohyun Kim, Duck Kyun Yoo, Suji Ha, Dong Hyun Jo, Chang Sik Cho, Dongmin Kang, Jeong Hun Kim, Junho Chung   +10 more
core   +1 more source

An Endostatin-lentivirus (ES-LV)-EPC gene therapy agent for suppression of neovascularization in oxygen-induced retinopathy rat model

BMC Molecular and Cell Biology, 2020
Background Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy.
Jing Ai, Jian Ma, Zhi-Qing Chen, Jun-Hui Sun, Ke Yao   +4 more
doaj   +1 more source

Lipid Mediators, M2 Macrophages, and Pathological Neovascularization [PDF]

Trends in Molecular Medicine, 2018
Sasaki and colleagues [1] (JCI Insight 2018;3,e96902) identified the leukocyte inflammatory lipid mediator leukotriene B4 (LTB4)/LTB4 receptor 1 receptor-signaling axis in M2 macrophages as a causal pathway for the vascular endothelial growth factor-dependent pathological neovascularization in a mouse model that mimics wet age-related macular ...
Steven L, Swendeman, Timothy, Hla
openaire   +2 more sources

Significance of microvessel density in prostate cancer core biopsy [PDF]

Vojnosanitetski Pregled, 2015
Background/Aim. In prostate tumors, angiogenesis, measured as microvessel density, is associated with tumor stage and Gleason score. The aim of this study was determine neovascularization of prostatic adenocarcinomas in core biopsies and ...
Salapura-Dugonjić Aleksandra, Knežević-Ušaj Slavica, Eri Živka, Tadić-Latinović Ljiljana   +3 more
doaj   +1 more source

Angiogenesis in squamous precancerous cervical lesions [PDF]

Vojnosanitetski Pregled, 2007
Background/Aim. Vascularisation is one of basic tumor's characteristics. Neoangiogenesis starts at the stage of the dysplastic epithelial changes, thus before the progression into invasive lesion. This study was designed to determine the relation between
Panjković Milan, Ivković-Kapicl Tatjana   +1 more
doaj   +1 more source

Potential Role for ADAM15 in Pathological Neovascularization in Mice [PDF]

Molecular and Cellular Biology, 2003
ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of molecules on the cell surface or extracellular matrix.
Keisuke, Horiuchi, Gisela, Weskamp, Lawrence, Lum, Hans-Peter, Hammes, Hui, Cai, Thomas A, Brodie, Thomas, Ludwig, Riccardo, Chiusaroli, Roland, Baron, Klaus T, Preissner, Katia, Manova, Carl P, Blobel   +11 more
openaire   +2 more sources

Fluorescein angiography compared to three-dimensional measurements by the retinal thickness analyzer in classic choroidal neovascularization [PDF]

, 2007
Purpose: To compare and correlate imaging of classic subfoveal choroidal neovascularization (CNV) with noninvasive 3-dimensional imaging by the retinal thickness analyzer (RTA) to conventional fluorescein angiography (FA).
Strauss, R. W., Rombold, F., Neubauer, A. S., Kampik, Anselm   +3 more
core   +1 more source

Co-existent choroidal neovascular membrane and macular hole in pathologic myopia:a long follow-up clinical outcome and literature review

International Journal of Ophthalmology, 2013
Choroidal neovascularization (CNV) is an uncommon complication associated with a macular hole. In this case report of a rare condition, we present a pathologic myopia patient with a co-existent macular hole and choroidal neovascular membrane. The patient
Zhi-Qing Chen, Ji-Jian Lin, Pan-Pan Ye, Li Zhang, Xiao-Yun Fang   +4 more
doaj   +1 more source

VEGF(164)-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization [PDF]

, 2003
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted.
Ogura, Y, Ng, Yin-Shan, Adamis, Anthony P., Kenji Yamashiro, Usui, Tomohiko, Hida, Tetsuo, Yuichi Kaji, Evangelos S. Gragoudas, Yin-Shan Ng, Shiro Amano, Amano, Shiro, Miller, Joan W., Yuichiro Ogura, Patricia A. D'Amore, Ambati, Jayakrishna, Shima, David T., Gragoudas, Evangelos S., Miller, JW, D'Amore, PA, Yoshihisa Oguchi, Hida, T, Ishida, S, Gragoudas, ES, Usui, T, Tetsuo Hida, Ogura, Yuichiro, Tomohiko Usui, Jayakrishna Ambati, Shima, DT, Joan W. Miller, Kaji, Yuichi, D\u27Amore, Patricia A., Ambati, J, Adamis, AP, Anthony P. Adamis, Kaji, Y, Yamashiro, K, Amano, S, Oguchi, Y, Oguchi, Yoshihisa, David T. Shima, Yamashiro, Kenji, Susumu Ishida, Ishida, Susumu, Ng, YS   +44 more
core   +1 more source

Inhibition of pathologic retinal neovascularization by  -defensins

Blood, 2005
Proliferative retinopathies, such as those complicating prematurity and diabetes, are major causes of blindness. A prominent feature of these retinopathies is excessive neovascularization, which is orchestrated by the hypoxia-induced vascular endothelial growth factor (VEGF) stimulating endothelial cells and the integrin-mediated adhesive interactions ...
Matina, Economopoulou, Khalil, Bdeir, Douglas B, Cines, Franz, Fogt, Yasmina, Bdeir, Jacek, Lubkowski, Wuyuan, Lu, Klaus T, Preissner, Hans-Peter, Hammes, Triantafyllos, Chavakis   +9 more
openaire   +3 more sources