Results 21 to 30 of about 26,143 (267)

Oxidative and Nitrosative Stress in Age-Related Macular Degeneration: A Review of Their Role in Different Stages of Disease

Antioxidants, 2021
Although the exact pathogenetic mechanisms leading to age-related macular degeneration (AMD) have not been clearly identified, oxidative damage in the retina and choroid due to an imbalance between local oxidants/anti-oxidant systems leading to chronic ...
Caterina Toma, Stefano De Cillà, Aurelio Palumbo, Divya Praveen Garhwal, Elena Grossini   +4 more
doaj   +1 more source

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

Cell Reports, 2019
Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states.
Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung-Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. Garland, Glenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra   +32 more
doaj   +1 more source

Lack of netrin-4 modulates pathologic neovascularization in the eye [PDF]

Scientific Reports, 2016
AbstractNetrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization. To answer the question whether netrin-4 acts either pro- or anti-angiogenic, angiogenesis in the retina was assessed in Ntn-4−/− mice with oxygen-induced retinopathy (OIR) and laser ...
Norbert Kociok, Sergio Crespo-Garcia, Yong Liang, Sabrina V. Klein, Christina Nürnberg, Nadine Reichhart, Sergej Skosyrski, Eva Moritz, Anna-Karina Maier, William J. Brunken, Olaf Strauß, Manuel Koch, Antonia M. Joussen   +12 more
openaire   +2 more sources

Histological changes secondary to use of anti-angiogenic therapy after interruption of vasa vasorum flow in the descending aorta: results in a porcine model

Jornal Vascular Brasileiro, 2019
Background Anti-angiogenic regulators may have therapeutic implications for onset and progression of atherosclerosis. Objectives To demonstrate histological changes secondary to the use of bevacizumab in the aorta of pigs after interruption of flow in ...
Cyro Castro Júnior, Adamastor Humberto Pereira   +1 more
doaj   +1 more source

Key Multimodal Fundus Imaging Findings to Recognize Multifocal Choroiditis in Patients With Pathological Myopia

Frontiers in Medicine, 2022
Myopia represents a major socioeconomic burden with an increasing prevalence worldwide. Pathologic myopia refers to myopic patients with structural changes in the posterior pole including different patterns of chorioretinal atrophy, choroidal ...
Roberto Gallego-Pinazo, Sara Hernández, Rosa Dolz-Marco   +2 more
doaj   +1 more source

Predictors of pathologic stage in prostatic carcinoma. The role of neovascularity [PDF]

Cancer, 1994
Prostate adenocarcinoma is a significant cause of morbidity and mortality in older men. However, the histologic prevalence far exceeds clinically manifest disease. Increased screening has resulted in the detection of a large number of carcinomas of unknown malignant potential.
M K, Brawer, R E, Deering, M, Brown, S D, Preston, S A, Bigler   +4 more
openaire   +2 more sources

Thymidine phosphorylase and its possible correlation with the lung cancer phenotype features

Patologìâ, 2015
The tumor phenotype investigation is necessary for lung cancer drug therapy optimization. For this purpose is perspective to use the biochemical markers of angiogenesis. Thymidine phosphorylase may be one of them. Aim. The aim of study was to evaluate
E. M. Bakurova, R. V. Buzina, R. B. Kondratiuk, Yu. K. Gulkov, I. V. Vasilenko, B. G. Borzenko   +5 more
doaj   +1 more source

Management of Myopic Maculopathy: A Review

Türk Oftalmoloji Dergisi, 2023
Myopia, including pathologic myopia, has seen a significant increase in prevalence in recent years. It is a significant cause of irreversible vision loss worldwide and prediction models demonstrate the substantial future impact on the population.
William J. Anderson, Levent Akduman
doaj   +1 more source

Angiofluorographic Characteristics of Choroidal Neovascularization associated with Pathologic Myopia

romanian journal of ophthalmology, 2020
Purpose: To evaluate the incidence of choroidal neovascularization (CNV) in high myopic patients who experienced recent visual loss and to describe the characteristics of CNV that develop as a complication of pathologic myopia and were detected by fluorescein angiography (FA).
Tomi, Anca, Ştefan, Irina
openaire   +3 more sources

FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice

Cell Reports, 2017
Pathological neovascularization, a leading cause of blindness, is seen in retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration.
Zhongjie Fu, Yan Gong, Raffael Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Steven S. Meng, Samuel B. Burnim, Nicholas J. Saba, Thomas W. Fredrick, Peyton C. Morss, Ann Hellstrom, Saswata Talukdar, Lois E.H. Smith   +12 more
doaj   +1 more source