Results 11 to 20 of about 134,368 (295)

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

Cell Reports, 2019
Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states.
Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung-Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. Garland, Glenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra   +32 more
doaj   +2 more sources

Lack of netrin-4 modulates pathologic neovascularization in the eye [PDF]

Scientific Reports, 2016
Netrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization. To answer the question whether netrin-4 acts either pro-or anti-angiogenic, angiogenesis in the
Reichhart, Nadine, Skosyrski, Sergej, Moritz, Eva, Joussen, Antonia M., Koch, Manuel, Maier, Anna-Karina, Nürnberg, Christina, Brunken, William J., Crespo-Garcia, Sergio, Liang, Yong, Klein, Sabrina V., Kociok, Norbert, Strauß, Olaf   +12 more
core   +4 more sources

Factors associated with the recurrence of choroidal neovascularization in pathologic myopia

Frontiers in Medicine, 2022
PurposeTo investigate the factors associated with the recurrence of pathologic myopia choroidal neovascularization (PM-CNV).MethodsForty-eight eyes of 48 patients with PM-CNV treated with conbercept at least 6 months of follow-up were included ...
Ruixia Jing, Yuxia Bo, Lei Gao, Zhen Wang   +3 more
doaj   +3 more sources

FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice

Cell Reports, 2017
Pathological neovascularization, a leading cause of blindness, is seen in retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration.
Zhongjie Fu, Yan Gong, Raffael Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Steven S. Meng, Samuel B. Burnim, Nicholas J. Saba, Thomas W. Fredrick, Peyton C. Morss, Ann Hellstrom, Saswata Talukdar, Lois E.H. Smith   +12 more
doaj   +2 more sources

ANTI-ANGIOGENIC THERAPY IN PATIENTS WITH PATHOLOGIC MYOPIA AND CHOROIDAL NEOVASCULARIZATION

Acta Biomedica Scientifica, 2016
Purpose of the study: to study the efficacy and safety of Ranibizumab in patients with pathologic myopia and choroidal neovascularization (CNV). 22 patients (22 eyes) with myopic CNV were included in the study.
S. A. Korotkikh, E. V. Bobykin, G. V. Zhiborkin, A. Y. Anashkin, A. V. Berezin   +4 more
doaj   +3 more sources

Antivascular Endothelial Growth Factor for Choroidal Neovascularization in Pathologic Myopia

, 2010
Choroidal neovascularization (CNV) is the most common vision-threatening macular complication in pathologic myopia (PM) being detectable in 4-11% of the affected eyes. Treatment of PM-related CNV is still controversial.
Iacono P, Maurizio Battaglia Parodi, Bandello F., Francesco Bandello, Pierluigi Iacono, Battaglia Parodi M   +5 more
core   +3 more sources

Intravitreal aflibercept for the treatment of choroidal neovascularization associated with pathologic myopia: a pilot study

Clinical Ophthalmology, 2016
Andrii R Korol, Oleg S Zadorozhnyy, Volodymyr O Naumenko, Taras B Kustryn, Nataliya V Pasyechnikova The Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine, Odessa, Ukraine Purpose: To determine ...
Korol AR, Zadorozhnyy OS, Naumenko VO, Kustryn TB, Pasyechnikova NV   +4 more
doaj   +1 more source

Unilateral Optic Disc Neovascularization in a Patient with Optic Disc Pit Depending on Proliferative Diabetic Retinopathy

Bezmiâlem Science
Optic disc pit is an excavation of the optic disc that usually develops congenital or rarely acquired, mostly located in the inferotemporal part of the disc. It is usually asymptomatic but sometimes might be symptomathic with maculopathy development.
Atilla ŞAHİN, Cansu EKİNCİ ASLANOĞLU, Hakan ÖZDEMİR   +2 more
doaj   +2 more sources

Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization

Investigative Opthalmology & Visual Science, 2007
PURPOSE. Recently, it was revealed that the inhibition of nonproteolytic activation of prorenin led to significant suppression of ocular inflammation in endotoxin-induced uveitis.
Norihiro Nagai, Hajime Shinoda, Kazuo Tsubota, Kousuke Noda, Hiroshi Itoh, Susumu Ishida, Yoko Ozawa, Makoto Inoue, Shingo Satofuka, Atsuhiro Ichihara, Takashi Koto, Yuichi Oike   +11 more
core   +3 more sources

Choroidal Neovascularization and Coincident Perforating Scleral Vessels in Pathologic Myopia

European Journal of Ophthalmology, 2017
Purpose To describe the coincidence of perforating scleral vessels and choroidal neovascularization (CNV) in pathologic myopia. Methods Medical records and multimodal imaging were reviewed from patients with CNV secondary to pathologic myopia who ...
Querques, Lea, Carnevali, Adriano, Adriano Carnevali, Luigi A. De Vitis, Giuseppe Querques, De Vitis, Luigi A., Querques, Giuseppe, Bandello, Francesco, Francesco Bandello, Lea Querques, Chiara Giuffrè, Giuffrè, Chiara   +11 more
core   +3 more sources