Results 11 to 20 of about 125,954 (295)

Sema3f Protects Against Subretinal Neovascularization In Vivo

EBioMedicine, 2017
Pathological neovascularization of the outer retina is the hallmark of neovascular age-related macular degeneration (nAMD). Building on our previous observations that semaphorin 3F (Sema3f) is expressed in the outer retina and demonstrates anti ...
Ye Sun, Raffael Liegl, Yan Gong, Anima Bühler, Bertan Cakir, Steven S. Meng, Samuel B. Burnim, Chi-Hsiu Liu, Tristan Reuer, Peipei Zhang, Johanna M. Walz, Franziska Ludwig, Clemens Lange, Hansjürgen Agostini, Daniel Böhringer, Günther Schlunck, Lois E.H. Smith, Andreas Stahl   +17 more
doaj   +2 more sources

Specific ablation of PDGFRβ-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models

Communications Medicine, 2021
Lee et al. use an antibody-drug conjugate to treat pathologic ocular neovascularization in mouse models. The antibody-drug conjugate targets PDGFRβ-expressing pericytes, with similar therapeutic effects to an anti-VEGF agent and with limited unwanted ...
Seok Jae Lee, Soohyun Kim, Dong Hyun Jo, Chang Sik Cho, Su Ree Kim, Dongmin Kang, Jisu Chae, Duck Kyun Yoo, Suji Ha, Junho Chung, Jeong Hun Kim   +10 more
doaj   +2 more sources

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

Cell Reports, 2019
Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states.
Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung-Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. Garland, Glenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra   +32 more
doaj   +2 more sources

Lack of netrin-4 modulates pathologic neovascularization in the eye [PDF]

Scientific Reports, 2016
AbstractNetrins are a family of matrix-binding proteins that function as guidance signals. Netrin-4 displays pathologic roles in tumorigenesis and neovascularization. To answer the question whether netrin-4 acts either pro- or anti-angiogenic, angiogenesis in the retina was assessed in Ntn-4−/− mice with oxygen-induced retinopathy (OIR) and laser ...
Norbert Kociok, Sergio Crespo-Garcia, Yong Liang, Sabrina V. Klein, Christina Nürnberg, Nadine Reichhart, Sergej Skosyrski, Eva Moritz, Anna-Karina Maier, William J. Brunken, Olaf Strauß, Manuel Koch, Antonia M. Joussen   +12 more
openaire   +4 more sources

Intravitreal aflibercept for the treatment of choroidal neovascularization associated with pathologic myopia: a pilot study

Clinical Ophthalmology, 2016
Andrii R Korol, Oleg S Zadorozhnyy, Volodymyr O Naumenko, Taras B Kustryn, Nataliya V Pasyechnikova The Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine, Odessa, Ukraine Purpose: To determine ...
Korol AR, Zadorozhnyy OS, Naumenko VO, Kustryn TB, Pasyechnikova NV   +4 more
doaj   +1 more source

Role of Nonproteolytically Activated Prorenin in Pathologic, but Not Physiologic, Retinal Neovascularization

Investigative Opthalmology & Visual Science, 2007
Recently, it was revealed that the inhibition of nonproteolytic activation of prorenin led to significant suppression of ocular inflammation in endotoxin-induced uveitis. The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization.C57BL/6 neonatal mice ...
Shingo, Satofuka, Atsuhiro, Ichihara, Norihiro, Nagai, Takashi, Koto, Hajime, Shinoda, Kousuke, Noda, Yoko, Ozawa, Makoto, Inoue, Kazuo, Tsubota, Hiroshi, Itoh, Yuichi, Oike, Susumu, Ishida   +11 more
openaire   +3 more sources

Unilateral Optic Disc Neovascularization in a Patient with Optic Disc Pit Depending on Proliferative Diabetic Retinopathy

Bezmiâlem Science
Optic disc pit is an excavation of the optic disc that usually develops congenital or rarely acquired, mostly located in the inferotemporal part of the disc. It is usually asymptomatic but sometimes might be symptomathic with maculopathy development.
Atilla ŞAHİN, Cansu EKİNCİ ASLANOĞLU, Hakan ÖZDEMİR   +2 more
doaj   +2 more sources

Treatment of myopic choroidal neovascularization with intravitreal ranibizumab injections: the role of age

Clinical Ophthalmology, 2017
Dimitrios Karagiannis,1 Georgios A Kontadakis,1,2 Konstantinos Kaprinis,1 Athanassios Giarmoukakis,2 lias Georgalas,3 Efstratios A Parikakis,1 Miltiadis K Tsilimbaris2 1Ophthalmiatreio Eye Hospital of Athens, Athens, Greece; 2Department of Ophthalmology,
Karagiannis D, Kontadakis GA, Kaprinis K, Giarmoukakis A, Georgalas I, Parikakis EA, Tsilimbaris MK   +6 more
doaj   +1 more source

VISUAL ACUITY OUTCOMES OF RANIBIZUMAB TREATMENT IN PATHOLOGIC MYOPIC EYES WITH MACULAR RETINOSCHISIS AND CHOROIDAL NEOVASCULARIZATION [PDF]

, 2016
PURPOSE To investigate visual and morphological outcome in eyes with MRS and choroidal neovascularization (CNV) secondary to pathologic myopia treated with intravitreal (IVT) ranibizumab. METHODS Post hoc analysis of the patients included in the
Ceklic, Lala, Gekkieva, Margarita, Munk, Marion, Wolf-Schnurrbusch, Ute, Wolf, Sebastian   +4 more
core   +3 more sources

Two years follow-up outcome of verteporfin therapy for subfoveal choroidal neovascularization in pathologic myopia in Indian eyes

Indian Journal of Ophthalmology, 2008
Context: In India, refractive errors are a major cause of treatable blindness. Population surveys in southern India have shown prevalence of high myopia to be 4.32-4.54%. Photodynamic therapy (PDT) for choroidal neovascularization (CNV) caused by
Hussain Nazimul, Khanna Rohit, Das Taraprasad, Narayanan Raja, Sunday Oluleye, Bansal Azad, Reddy Rajeev   +6 more
doaj   +1 more source