Results 11 to 20 of about 26,135 (266)

Lipid Mediators, M2 Macrophages, and Pathological Neovascularization [PDF]

Trends in Molecular Medicine, 2018
Sasaki and colleagues [1] (JCI Insight 2018;3,e96902) identified the leukocyte inflammatory lipid mediator leukotriene B4 (LTB4)/LTB4 receptor 1 receptor-signaling axis in M2 macrophages as a causal pathway for the vascular endothelial growth factor-dependent pathological neovascularization in a mouse model that mimics wet age-related macular ...
Steven L, Swendeman, Timothy, Hla
openaire   +2 more sources

An Endostatin-lentivirus (ES-LV)-EPC gene therapy agent for suppression of neovascularization in oxygen-induced retinopathy rat model

BMC Molecular and Cell Biology, 2020
Background Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy.
Jing Ai, Jian Ma, Zhi-Qing Chen, Jun-Hui Sun, Ke Yao   +4 more
doaj   +1 more source

Specific ablation of PDGFRβ-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models

Communications Medicine, 2021
Lee et al. use an antibody-drug conjugate to treat pathologic ocular neovascularization in mouse models. The antibody-drug conjugate targets PDGFRβ-expressing pericytes, with similar therapeutic effects to an anti-VEGF agent and with limited unwanted ...
Seok Jae Lee, Soohyun Kim, Dong Hyun Jo, Chang Sik Cho, Su Ree Kim, Dongmin Kang, Jisu Chae, Duck Kyun Yoo, Suji Ha, Junho Chung, Jeong Hun Kim   +10 more
doaj   +1 more source

Sema3f Protects Against Subretinal Neovascularization In Vivo

EBioMedicine, 2017
Pathological neovascularization of the outer retina is the hallmark of neovascular age-related macular degeneration (nAMD). Building on our previous observations that semaphorin 3F (Sema3f) is expressed in the outer retina and demonstrates anti ...
Ye Sun, Raffael Liegl, Yan Gong, Anima Bühler, Bertan Cakir, Steven S. Meng, Samuel B. Burnim, Chi-Hsiu Liu, Tristan Reuer, Peipei Zhang, Johanna M. Walz, Franziska Ludwig, Clemens Lange, Hansjürgen Agostini, Daniel Böhringer, Günther Schlunck, Lois E.H. Smith, Andreas Stahl   +17 more
doaj   +1 more source

Significance of microvessel density in prostate cancer core biopsy [PDF]

Vojnosanitetski Pregled, 2015
Background/Aim. In prostate tumors, angiogenesis, measured as microvessel density, is associated with tumor stage and Gleason score. The aim of this study was determine neovascularization of prostatic adenocarcinomas in core biopsies and ...
Salapura-Dugonjić Aleksandra, Knežević-Ušaj Slavica, Eri Živka, Tadić-Latinović Ljiljana   +3 more
doaj   +1 more source

Potential Role for ADAM15 in Pathological Neovascularization in Mice [PDF]

Molecular and Cellular Biology, 2003
ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of molecules on the cell surface or extracellular matrix.
Keisuke, Horiuchi, Gisela, Weskamp, Lawrence, Lum, Hans-Peter, Hammes, Hui, Cai, Thomas A, Brodie, Thomas, Ludwig, Riccardo, Chiusaroli, Roland, Baron, Klaus T, Preissner, Katia, Manova, Carl P, Blobel   +11 more
openaire   +2 more sources

Angiogenesis in squamous precancerous cervical lesions [PDF]

Vojnosanitetski Pregled, 2007
Background/Aim. Vascularisation is one of basic tumor's characteristics. Neoangiogenesis starts at the stage of the dysplastic epithelial changes, thus before the progression into invasive lesion. This study was designed to determine the relation between
Panjković Milan, Ivković-Kapicl Tatjana   +1 more
doaj   +1 more source

Co-existent choroidal neovascular membrane and macular hole in pathologic myopia:a long follow-up clinical outcome and literature review

International Journal of Ophthalmology, 2013
Choroidal neovascularization (CNV) is an uncommon complication associated with a macular hole. In this case report of a rare condition, we present a pathologic myopia patient with a co-existent macular hole and choroidal neovascular membrane. The patient
Zhi-Qing Chen, Ji-Jian Lin, Pan-Pan Ye, Li Zhang, Xiao-Yun Fang   +4 more
doaj   +1 more source

Inhibition of pathologic retinal neovascularization by  -defensins

Blood, 2005
Proliferative retinopathies, such as those complicating prematurity and diabetes, are major causes of blindness. A prominent feature of these retinopathies is excessive neovascularization, which is orchestrated by the hypoxia-induced vascular endothelial growth factor (VEGF) stimulating endothelial cells and the integrin-mediated adhesive interactions ...
Matina, Economopoulou, Khalil, Bdeir, Douglas B, Cines, Franz, Fogt, Yasmina, Bdeir, Jacek, Lubkowski, Wuyuan, Lu, Klaus T, Preissner, Hans-Peter, Hammes, Triantafyllos, Chavakis   +9 more
openaire   +3 more sources

El cáncer en la función mitocondrial

Revista de la Facultad de Medicina, 2018
Metabolism alterations are associated with the loss of mitochondrial function in tumor cells. Current research discuss whether such loss is evident in function itself, or if cells can provide maximum stability to its functions. More studies are needed to
Sofía Isabel Freyre-Bernal, Jhan Sebastián Saavedra-Torres, Luisa Fernanda Zúñiga-Cerón, Wilmer Jair Díaz -Córdoba, María Virginia Pinzón-Fernández   +4 more
doaj   +1 more source