Results 21 to 30 of about 1,067,090 (283)

Celastrol inhibits pathologic neovascularization in oxygen-induced retinopathy by targeting the miR-17-5p/HIF-1α/VEGF pathway

Cell Cycle, 2022
Retinopathy of prematurity (ROP), which is characterized by retinal neovascularization (RNV), is a major cause of neonatal blindness. The primary treatment for ROP is anti-vascular endothelial growth factor (VEGF) therapy, which is costly and can rapidly
Kun Zhao, Yaping Jiang, Jing Zhang, Jing-Min Shi, Pengxiang Zheng, Chuanxi Yang, Yihui Chen   +6 more
semanticscholar   +1 more source

Topical Nanoemulsion of a Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis

Ophthalmology Science, 2022
Purpose: To test the efficacy of runt-related transcription factor 1 (RUNX1) inhibition with topical nanoemulsion containing Ro5-3335 (eNano-Ro5) in experimental ocular neovascularization. Design: Preclinical experimental study.
Santiago Delgado-Tirado, MD, Lucia Gonzalez-Buendia, MD, Miranda An, BA, Dhanesh Amarnani, MS, Daniela Isaacs-Bernal, BSc, Hannah Whitmore, PhD, Said Arevalo-Alquichire, PhD, David Leyton-Cifuentes, BME, Jose M. Ruiz-Moreno, MD, PhD, Joseph F. Arboleda-Velasquez, MD, PhD, Leo A. Kim, MD, PhD   +10 more
doaj   +1 more source

Correlation between the expression of vegf and survival in osteosarcoma [PDF]

Acta Ortopédica Brasileira, 2014
Objective: To present a series of 50 consecutive patients with non-metastatic extremity osteosarcoma, and attempt to correlate expression of the vascular endothelial growth factor (VEGF) protein in biopsy tissue to their prognosis regarding overall ...
André Mathias Baptista, André Ferrari De França Camargo, Renée Zon Filippi, Cláudia Regina Gomes Cardim Mendes De Oliveira, Raymundo Soares De Azevedo Neto, Olavo Pires De Camargo   +5 more
doaj   +1 more source

Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2019
Objective— Pathological neovascularization is crucial for progression and morbidity of serious diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. While mechanisms of ongoing pathological neovascularization have been extensively studied, the initiating pathological vascular remodeling (PVR ...
Anthony Mukwaya, Qiaolin Deng, Beatrice Bourghardt Peebo, Antje Biesemeier, Rickard Sandberg, Ulrich Schraermeyer, Claudia Gerri, Michele Marass, Julianna Kele, Anders Kvanta, Parviz Mammadzada, Luis del Peso, Luis del Peso, Daniel Ramsköld, Michael R. Taylor, Neil Lagali, Zaheer Ali, Camilla Hildesjö, Helder André, Anton Lennikov, Maria Ntzouni, Yihai Cao, Renhai Cao, John F. Steffensen, Lasse Jensen, Sarantis Giatrellis   +25 more
openaire   +8 more sources

ADAM9 Is Involved in Pathological Retinal Neovascularization [PDF]

Molecular and Cellular Biology, 2009
Pathological ocular neovascularization, caused by diabetic retinopathy, age-related macular degeneration, or retinopathy of prematurity, is a leading cause of blindness, yet much remains to be learned about its underlying causes. Here we used oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV) to assess the ...
Peter A. Campochiaro, Steven L. Swendeman, Tsunehiko Yoshida, Carl P. Blobel, Carl P. Blobel, Victor H. Guaiquil, Sai H. Chavala   +6 more
openaire   +3 more sources

Successful Use of Conbercept to Treat Choroidal Neovascularization: A Case Report

Case Reports in Ophthalmology, 2022
Chronic urticaria is a dermatological condition characterized by the appearance of wheals or angioedema longer than 6 weeks. It could cause serious complications such as laryngeal edema, vasculitis, and diarrhea.
Jin Yang, Zheng Liu, Tao Liu
doaj   +1 more source

Interleukin-18 regulates pathological intraocular neovascularization [PDF]

Journal of Leukocyte Biology, 2007
AbstractRecently, the proinflammatory cytokine IL-18 has been shown to have a role in angiogenesis. This study aimed to elucidate its role in abnormal neovascularization (NV) in an oxygen-induced retinopathy (OIR) mouse model of the retinopathy seen in human premature newborns.
Yasuhiro Ikeda, Young Joon Jo, Yasuaki Hata, Yukio Sassa, Kuniaki Hijioka, Chikako Tsutsumi-Miyahara, Tatsuro Ishibashi, Shizuo Akira, Hong Qiao, Takeru Yoshimura, Koh Hei Sonoda   +10 more
openaire   +3 more sources

Evaluation of a novel deep learning based screening system for pathologic myopia [PDF]

International Journal of Ophthalmology, 2023
AIM: To evaluate the clinical application value of the artificial intelligence assisted pathologic myopia (PM-AI) diagnosis model based on deep learning. METHODS: A total of 1156 readable color fundus photographs were collected and annotated based on the
Pei-Fang Ren, Xu-Yuan Tang, Chen-Ying Yu, Li-Li Zhu, Wei-Hua Yang, Ye Shen   +5 more
doaj   +1 more source

An Endostatin-lentivirus (ES-LV)-EPC gene therapy agent for suppression of neovascularization in oxygen-induced retinopathy rat model

BMC Molecular and Cell Biology, 2020
Background Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy.
Jing Ai, Jian Ma, Zhi-Qing Chen, Jun-Hui Sun, Ke Yao   +4 more
doaj   +1 more source

Specific ablation of PDGFRβ-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models

Communications Medicine, 2021
Lee et al. use an antibody-drug conjugate to treat pathologic ocular neovascularization in mouse models. The antibody-drug conjugate targets PDGFRβ-expressing pericytes, with similar therapeutic effects to an anti-VEGF agent and with limited unwanted ...
Seok Jae Lee, Soohyun Kim, Dong Hyun Jo, Chang Sik Cho, Su Ree Kim, Dongmin Kang, Jisu Chae, Duck Kyun Yoo, Suji Ha, Junho Chung, Jeong Hun Kim   +10 more
doaj   +1 more source