Results 21 to 30 of about 34,072 (291)

Arterial pathology in canine mucopolysaccharidosis-I and response to therapy. [PDF]

, 2011
Mucopolysaccharidosis-I (MPS-I) is an inherited deficiency of α-L-iduronidase (IdU) that causes lysosomal accumulation of glycosaminoglycans (GAG) in a variety of parenchymal cell types and connective tissues.
Dickson, Patricia I, Ellinwood, N Matthew, Kakkis, Emil D, Lyons, Jeremiah A, McEntee, Michael F, Passage, Merry B, Wall, Jonathan S   +6 more
core   +3 more sources

Co-existent choroidal neovascular membrane and macular hole in pathologic myopia:a long follow-up clinical outcome and literature review

International Journal of Ophthalmology, 2013
Choroidal neovascularization (CNV) is an uncommon complication associated with a macular hole. In this case report of a rare condition, we present a pathologic myopia patient with a co-existent macular hole and choroidal neovascular membrane. The patient
Zhi-Qing Chen, Ji-Jian Lin, Pan-Pan Ye, Li Zhang, Xiao-Yun Fang   +4 more
doaj   +1 more source

Long-term follow-up of myopic choroidal neovascularization treated with ranibizumab [PDF]

, 2011
PURPOSE: To evaluate the long-term safety and efficacy of intravitreal ranibizumab in the treatment of myopic choroidal neovascularization (CNV). METHODS: Three-year retrospective, nonrandomized, interventional case series.
Cachulo, ML, Figueira, J, Fonseca, P, Franqueira, N, Marques, I, Pires, I, Silva, R   +6 more
core   +1 more source

El cáncer en la función mitocondrial

Revista de la Facultad de Medicina, 2018
Metabolism alterations are associated with the loss of mitochondrial function in tumor cells. Current research discuss whether such loss is evident in function itself, or if cells can provide maximum stability to its functions. More studies are needed to
Sofía Isabel Freyre-Bernal, Jhan Sebastián Saavedra-Torres, Luisa Fernanda Zúñiga-Cerón, Wilmer Jair Díaz -Córdoba, María Virginia Pinzón-Fernández   +4 more
doaj   +1 more source

Oxidative and Nitrosative Stress in Age-Related Macular Degeneration: A Review of Their Role in Different Stages of Disease

Antioxidants, 2021
Although the exact pathogenetic mechanisms leading to age-related macular degeneration (AMD) have not been clearly identified, oxidative damage in the retina and choroid due to an imbalance between local oxidants/anti-oxidant systems leading to chronic ...
Caterina Toma, Stefano De Cillà, Aurelio Palumbo, Divya Praveen Garhwal, Elena Grossini   +4 more
doaj   +1 more source

Inhibition of pathologic retinal neovascularization by  -defensins

Blood, 2005
Proliferative retinopathies, such as those complicating prematurity and diabetes, are major causes of blindness. A prominent feature of these retinopathies is excessive neovascularization, which is orchestrated by the hypoxia-induced vascular endothelial growth factor (VEGF) stimulating endothelial cells and the integrin-mediated adhesive interactions ...
Klaus T. Preissner, Yasmina Bdeir, Matina Economopoulou, Hans-Peter Hammes, Khalil Bdeir, Wuyuan Lu, Franz Fogt, Douglas B. Cines, Jacek Lubkowski, Triantafyllos Chavakis   +9 more
openaire   +4 more sources

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future [PDF]

, 2019
Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies.
Corson, Timothy W., Park, Bomina
core   +1 more source

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

Cell Reports, 2019
Summary: Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states.
Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohnaka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung-Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Kadam, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. Garland, Glenn Stoller, Jaideep Chaudhary, Larry Norton, Rajesh Kumar Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, Robert Benezra   +32 more
doaj   +1 more source

Angiofluorographic Characteristics of Choroidal Neovascularization associated with Pathologic Myopia

romanian journal of ophthalmology, 2020
Purpose: To evaluate the incidence of choroidal neovascularization (CNV) in high myopic patients who experienced recent visual loss and to describe the characteristics of CNV that develop as a complication of pathologic myopia and were detected by fluorescein angiography (FA).
Irina Stefan, Anca Tomi
openaire   +3 more sources

Histological changes secondary to use of anti-angiogenic therapy after interruption of vasa vasorum flow in the descending aorta: results in a porcine model

Jornal Vascular Brasileiro, 2019
Background Anti-angiogenic regulators may have therapeutic implications for onset and progression of atherosclerosis. Objectives To demonstrate histological changes secondary to the use of bevacizumab in the aorta of pigs after interruption of flow in ...
Cyro Castro Júnior, Adamastor Humberto Pereira   +1 more
doaj   +1 more source