Results 241 to 250 of about 1,820,535 (282)

Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways

Cell Proliferation, EarlyView.
IL10_ApoEVs, generated during IL‐10‐induced fibroblast apoptosis, reprogram fibroblast metabolism and inhibit fibrosis to promote scarless skin healing. By enhancing mitochondrial OXPHOS, suppressing glycolysis, and downregulating Hedgehog signaling, IL10_ApoEVs shift collagen deposition toward regenerative type III collagen, offering a novel strategy ...
Yang Zou, Jinglun Zhang, Wenxuan Mao, Shuting Jiang, Cheng Xu, Jiayi Meng, Heng Dong, Yongbin Mou   +7 more
wiley   +1 more source

Recent Insights into Roles of Hypoxia-Inducible Factors in Retinal Diseases. [PDF]

Int J Mol Sci
Lee D, Tomita Y, Miwa Y, Kunimi H, Nakai A, Shoda C, Negishi K, Kurihara T.   +7 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Lactate-binding protein DNMT3A in HRMECs promotes angiogenesis by upregulating VEGFA through HIF-1α lactylation. [PDF]

Genome Biol
Wang X, Huang J, Fan W, Li N, Yang H, Yang W, Li W, Li R, Liu J, Li X, Zhou Q, Hou S.   +11 more
europepmc   +1 more source

Vaginal Microbiota and Ovarian Cancer: A New Frontier in Immunomodulation and Diagnosis

Immunology, EarlyView.
Microbial imbalance, dysbiosis, plays a role in ovarian carcinogenesis by interacting with the immune system and altering inflammatory pathways, notably Th17 pathways. In contrast, eubiosis, characterised by Lactobacillus dominance, protects against infections and maintains hormone metabolism.
Wafa Babay, Mariem Garci, Ahmed Baligh Laaribi, Nabil Mathlouthi, Imene Ouzari   +4 more
wiley   +1 more source

Biological Regulation of HIF-1α and Its Role in Therapeutic Angiogenesis for Treatment of Ischemic Cardiovascular Disease. [PDF]

Int J Mol Sci
Carmichael E, Reme AS, Bosco PJ, Ortiz YY, Ramos DA, Gomez K, Nguyen BN, Bornak A, Liu ZJ, Velazquez OC.   +9 more
europepmc   +1 more source

Erythrocyte deformability correlates with microvascular ischemia and disease severity in diabetic retinopathy

Journal of Diabetes Investigation, EarlyView.
Under physiological conditions, deformable erythrocytes pass smoothly through the capillary network, maintaining retinal capillary perfusion (A). In pathological conditions, reduced erythrocyte deformability causes irregular passage and stagnation within capillaries, resulting in localized blood flow stasis and microvascular congestion, leading to ...
Ye Eun Han, Joon Seo Lim, Yulim Kim, Inhye Kim, Jun Sung Moon, Junyeop Lee   +5 more
wiley   +1 more source

Three-Dimensional Models of the Dental Pulp: Bridging Fundamental Biology and Regenerative Therapy. [PDF]

Int J Mol Sci
Smaida R, Hua G, Benkirane-Jessel N, Fioretti F.   +3 more
europepmc   +1 more source

The exposomal imprint on rosacea: More than skin deep

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Rosacea reflects systemic and environmental interactions, not just a skin disorder. Key factors include environmental triggers, genetic and microbiome influences, diagnostic gaps in skin of colour and social determinants. Advances in multi‐omics and exposome integration highlight pathways towards precision medicine, prevention and equitable, patient ...
Katerina Grafanaki, Daniella Bakoli Sgourou, Alexandros Maniatis, Efstathia Pasmatzi   +3 more
wiley   +1 more source

The impact of natural and engineered extracellular vesicles on post-myocardial infarction angiogenesis. [PDF]

Stem Cell Res Ther
Guo H, Kong X, Jiang D, Jiang J, Bu Y, Wang D, Lu C, Zhao X.   +7 more
europepmc   +1 more source