Results 171 to 180 of about 8,883 (209)

Nephrin is expressed in the pancreatic beta cells [PDF]

Diabetologia, 2001
The NPHS1 gene product, nephrin, is a crucial component of the glomerular filtration barrier preventing proteinuria and previously assumed to be kidney-specific. The aim of this study was to describe the expression of nephrin mRNA and protein in human pancreas as well as identify the nephrin-expressing cell types.RNA dot blot, reverse transcriptase ...
Tuula Palmen, Heikki Ahola, Jaan Palgi   +2 more
exaly   +3 more sources

Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis

Kidney International, 2008
Phosphorylation of tyrosine residue (Y1204) of rat nephrin by Fyn kinase allows Nck adaptor protein binding to nephrin motifs, which include the phosphorylated tyrosine. This phosphorylation-dependent switch induces actin polymerization in a cell culture
Hiroshi Kawachi
exaly   +2 more sources

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Monoclonal Antibodies to Human Nephrin

Hybridoma and Hybridomics, 2004
Nephrin is a 180-200-kDa transmembrane protein of the immunoglobulin superfamily. In the kidney, nephrin localizes to the slit diaphragm (SD) between interdigitating podocyte foot processes and mutations in the nephrin gene cause congenital nephrotic syndrome.
Vesa, Ruotsalainen, Paula, Reponen, Jamshid, Khoshnoodi, Pekka, Kilpeläinen, Karl, Tryggvason   +4 more
openaire   +2 more sources

Nephrin in human lymphoid tissues

Cellular and Molecular Life Sciences CMLS, 2006
When nephrin, the protein product of NPHS1, was cloned, it was proposed to be specific for the kidney glomerular podocytes. Recently, however, new reports have emerged verifying additional nephrin expression sites, particularly the insulin-producing beta cells of the pancreas, as well as the central nervous system. In this study, we demonstrate nephrin
E, Aström, J, Rinta-Valkama, M, Gylling, H, Ahola, A, Miettinen, T, Timonen, H, Holthöfer   +6 more
openaire   +2 more sources

An update: the role of Nephrin inside and outside the kidney [PDF]

Science China Life Sciences, 2015
Nephrin is a key molecule in podocytes to maintain normal slit diaphragm structure. Nephin interacts with many other podocyte and slit diaphragm protein and also mediates important cell signaling pathways in podocytes. Loss of nephrin during the development leads to the congenital nephrotic syndrome in children. Reduction of nephrin expression is often
John Cijiang He, Li Xuezhu, He John Cijiang   +2 more
exaly   +3 more sources

Recovery and maintenance of nephrin expression in cultured podocytes and identification of HGF as a repressor of nephrin

American Journal of Physiology-Renal Physiology, 2007
Cultured podocytes easily lose expression of nephrin. In this report, we developed optimum media for recovery and maintenance of nephrin gene expression in murine podocytes. Using reporter podocytes, we found that activity of the nephrin gene promoter was enhanced by DMEM/F12 or α-MEM compared with RPMI-1640.
Yosuke, Takano, Kozue, Yamauchi, Nobuhiko, Hiramatsu, Ayumi, Kasai, Kunihiro, Hayakawa, Makiko, Yokouchi, Jian, Yao, Masanori, Kitamura   +7 more
openaire   +2 more sources

Autoantibodies Targeting Nephrin in Podocytopathies

New England Journal of Medicine
Minimal change disease and primary focal segmental glomerulosclerosis in adults, along with idiopathic nephrotic syndrome in children, are immune-mediated podocytopathies that lead to nephrotic syndrome. Autoantibodies targeting nephrin have been found in patients with minimal change disease, but their clinical and pathophysiological roles are unclear ...
Felicitas E. Hengel, Silke Dehde, Moritz Lassé, Gunther Zahner, Larissa Seifert, Annabel Schnarre, Oliver Kretz, Fatih Demir, Hans O. Pinnschmidt, Florian Grahammer, Renke Lucas, Lea Maxima Mehner, Tom Zimmermann, Anja M. Billing, Jun Oh, Adele Mitrotti, Paola Pontrelli, Hanna Debiec, Claire Dossier, Manuela Colucci, Francesco Emma, William E. Smoyer, Astrid Weins, Franz Schaefer, Nada Alachkar, Anke Diemert, Julien Hogan, Elion Hoxha, Thorsten Wiech, Markus M. Rinschen, Pierre Ronco, Marina Vivarelli, Loreto Gesualdo, Nicola M. Tomas, Tobias B. Huber   +34 more
openaire   +9 more sources

Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocytes

Kidney International, 2006
Downregulation of nephrin in podocytes leads to development of proteinuria in human and experimental kidney diseases. However, little is understood about pathophysiologic substances that regulate nephrin expression.
Jian Yao
exaly   +2 more sources