Results 41 to 50 of about 173,599 (327)

Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities

Nature Communications, 2020
Emerging urinary biomarkers continue to show promise in evaluating lupus nephritis (LN). Here, we screen urine from active LN patients for 1129 proteins using an aptamer-based platform, followed by ELISA validation in two independent cohorts comprised of
Samantha Stanley, Kamala Vanarsa, S. Soliman, Deena Habazi, C. Pedroza, Gabriel Gidley, Ting Zhang, Shree Mohan, E. Der, H. Suryawanshi, T. Tuschl, J. Buyon, C. Putterman, C. Mok, M. Petri, R. Saxena, C. Mohan   +16 more
semanticscholar   +1 more source

Novel clinical and genetic insights into Gitelman syndrome from 95 Chinese patients

Human Genomics
Background Gitelman syndrome (GS) is a rare tubulopathy with clinical and genetic heterogeneity. This study aimed to investigate the characteristics of Chinese GS patients. Methods The diagnosis of GS was established by combining clinical phenotypes with
Xiaomeng Shi, Lu Zhang, Xing Chen, Peijin Bai, Leping Shao   +4 more
doaj   +1 more source

Reduction in Renal Relapse and Preservation of Long‐Term Kidney Function After Lupus Low Disease Activity in Patients With Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Lupus low disease activity state (LLDAS) is a validated treatment target in systemic lupus erythematosus (SLE), but limited studies have explored the role of LLDAS in lupus nephritis (LN). This study aims to investigate the frequency and predictors of LLDAS attainment and its benefit on LN relapse and renal function preservation in patients ...
Chak Kwan Cheung, Desmond Y. H. Yap, Ka Lai Lee, Philip H. Li, Iris Y. K. Tang, Chak Sing Lau, Shirley C. W. Chan   +6 more
wiley   +1 more source

Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis

Science Translational Medicine, 2020
HIF-1 dictates effector function of infiltrating T cells in lupus, causing tissue damage that can be abrogated by its blockade in murine models. Hypoxic autoimmunity Systemic lupus erythematosus causes severe damage in multiple organs, including the ...
Ping-Min Chen, Parker C. Wilson, J. Shyer, M. Veselits, H. Steach, Can Cui, G. Moeckel, M. Clark, J. Craft   +8 more
semanticscholar   +1 more source

Hydroxychloroquine Associated With Lower Glomerular Filtration Rate Decline in Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) protects kidney function in lupus nephritis (LN) by preventing flares, yet some cohort studies show no significant benefit in kidney function with HCQ. Clarifying these conflicting findings by showing early and long‐term benefits of HCQ on kidney function preservation is critical.
Shivani Garg, Brad Rovin, Brad C. Astor, Tripti Singh, Fauzia Hollnagel, Megan Kuik, Lexie Kolton, Callie Saric, S. Sam Lim, Christie M. Bartels   +9 more
wiley   +1 more source

A predictive model to explore risk factors for Henoch–Schönlein purpura nephritis in children: a retrospective cross-sectional study

Frontiers in Public Health
ObjectiveThe risk factors for Henoch–Schönlein purpura nephritis (HSPN) remain largely unclear, particularly in family environment and vaccination.
Qianwen Yang, Qianwen Yang, Maoyang Zhang, Zilong Dong, Fang Deng   +4 more
doaj   +1 more source

Çocuklarda Henoch Schönlein purpurası: 46 olgunun geriye dönük analizi ve literatürün incelenmesi

Sakarya Tıp Dergisi, 2015
AmaçHenoch Schönlein purpurası (HSP) tanılı hastaların klinik ve laboratuvar karakteristiklerinin değerlendirilmesi, prognozu etkileyen risk faktörlerinin literatür eşliğinde incelenmesi.Gereç ve yöntemAbant İzzet Baysal Üniversitesi Tıp Fakültesi Çocuk ...
Betül Şereflican, Mervan Bekdaş, Mustafa Erkoçoğlu, Nadir Göksügür, Sevil Bilir Göksügür   +4 more
doaj   +1 more source

Integrated urine proteomics and renal single-cell genomics identify an interferon-γ response gradient in lupus nephritis.

JCI Insight, 2020
Lupus nephritis, one of the most serious manifestations of systemic lupus erythematosus (SLE), has both a heterogeneous clinical and pathological presentation.
A. Fava, J. Buyon, C. Mohan, Ting Zhang, H. M. Belmont, P. Izmirly, R. Clancy, J. M. Monroy Trujillo, D. Fine, Yuji Zhang, L. Magder, Deepak A. Rao, A. Arazi, C. Berthier, A. Davidson, B. Diamond, N. Hacohen, D. Wofsy, W. Apruzzese, The Accelerating Medicines Partnership, S. Raychaudhuri, M. Petri   +21 more
semanticscholar   +1 more source

Identifying High‐Impact Solutions to Address Racial and Ethnic Health Disparities in Lupus: A Consensus‐Based Approach

Arthritis Care &Research, EarlyView.
Objective We conducted formative research aimed at identifying solutions that address inequitable health outcomes in lupus due to adverse social determinants of health (SDoH). Methods We conducted a search for keywords, which provided insights into potential solutions and initiatives underway. An advisory panel of lupus experts iteratively reviewed the
Joy Buie, Michael P. Fisher, Kristen Backor, Hannah Tyldsley, Ashira Blazer, Candace Feldman, Andrea Knight, S. Sam Lim, Barbara Ann Polk, Ed Yelin, Edith Williams, Karen H. Costenbader   +11 more
wiley   +1 more source

Prevalence, Determinants, and Outcomes of Low Disease Activity and Remission Attainment in Patients With Systemic Lupus Erythematosus That Is Clinically Active

Arthritis Care &Research, EarlyView.
Objective This study aimed to identify in patients with systemic lupus erythematosus (SLE) with clinically active disease the attainment of frequency and determinants of Lupus Low Disease Activity State (LLDAS) and Definition of Remission in SLE (DORIS) and the frequency and determinants of flare and damage accrual after target attainment.
Yanjie Hao, Dylan Hansen, Rangi Kandane‐Rathnayake, Worawit Louthrenoo, Yi‐Hsing Chen, Jiacai Cho, Aisha Lateef, Laniyati Hamijoyo, Shue Fen Luo, Yeong‐Jian Jan Wu, Sandra Navarra, Leonid Zamora, Zhanguo Li, Sargunan Sockalingam, Yasuhiro Katsumata, Masayoshi Harigai, Zhuoli Zhang, Madelynn Chan, Jun Kikuchi, Tsutomu Takeuchi, Sang‐Cheol Bae, Fiona Goldblatt, Sean O'Neill, Kristine (Pek Ling) Ng, Annie Law, B. M. D. B. Basnayake, Nicola Tugnet, Sunil Kumar, Cherica Tee, Michael Tee, Naoaki Ohkubo, Yoshiya Tanaka, Shirley Chan, C. S. Lau, Vera Golder, Alberta Hoi, Shereen Oon, Eric Morand, Mandana Nikpour, for the Asia‐Pacific Lupus Collaboration   +39 more
wiley   +1 more source