Results 11 to 20 of about 53,664 (239)
Hnf1beta and nephron segmentation [PDF]
Pediatric Nephrology, 2013 The nephron is the functional unit that executes the homeostatic roles of the kidney in vertebrates. Critical to this function is the physical arrangement of the glomerular blood filter attached to a tubular epithelium that is subdivided into specialized proximal and distal segments.
Naylor, RW; id_orcid 0000-0003-2901-7677 +1 more
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Organization of nephron function
American Journal of Physiology-Renal Physiology, 1983 Recent studies of mammalian nephron segments have revealed an unexpected diversity of renal transport functions. Most substances are transported by several segments, and the transport mechanisms differ from segment to segment. In this paper we review some of these findings in order to fit them into an integrated picture of kidney function.
M, Knepper, M, Burg
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Synchronization phenomena in nephron–nephron interaction [PDF]
Chaos: An Interdisciplinary Journal of Nonlinear Science, 2001 Experimental data for tubular pressure oscillations in rat kidneys are analyzed in order to examine the different types of synchronization that can arise between neighboring functional units. For rats with normal blood pressure, the individual unit (the nephron) typically exhibits regular oscillations in its tubular pressure and flow variations.
Holstein-Rathlou, NH +3 more
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Genetics and the nephron [PDF]
Archives of disease in childhood - Education & practice edition, 2013 There have been phenomenal advances in our understanding of renal biology over the last 20 years through our ability to define the genetic mutations causing kidney disease in children. This review will take you through a trip down the nephron and highlight how these conditions may present to the paediatrician and the molecular basis for their ...
Marlais, M, Coward, R J
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Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment [PDF]
, 2018 A normal endowment of nephrons in the mammalian kidney requires a balance of nephron progenitor self-renewal and differentiation throughout development. Here, we provide evidence for a novel action of ureteric branch tip-derived Wnt11 in progenitor cell ...
O’brien, LL +12 more
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Interacting information streams on the nephron arterial network. [PDF]
, 2023 Blood flow and glomerular filtration in the kidney are regulated by two mechanisms acting on the afferent arteriole of each nephron. The two mechanisms operate as limit cycle oscillators, each responding to a different signal.
Holstein-Rathlou, Niels-Henrik +5 more
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Gene expression analysis in microdissected renal tissue - Current challenges and strategies [PDF]
, 2002 The architecture and compartmentalization of the kidney has stimulated the development of an array of microtechniques to study the functional differences between the distinct nephron segments. With the vast amounts of genomic sequence data now available,
Cohen, C. D., Kretzler, M.
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Lithium treatment reduces the renal kallikrein excretion rate [PDF]
, 1990 Lithium treatment reduces the renal kallikrein excretion rate. Lithium salts are widely used agents for the prophylactic treatment of affective disorders. Lithium salts may be associated with distal nephron dysfunction.
Marin-Grez, Marcos +4 more
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Nephrology Dialysis Transplantation, 2002 One of the most remarkable transformations of cells during organogenesis is the epithelial transformation of nephrogenic mesenchyme to secretory nephrons. During recent years, gene targeting and organ culture approaches have been used efficiently to resolve key molecules involved in this multistage process.
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International Journal of Preventive Medicine, 2022 Backgrounds: Most of the cancer patients with solid tumor are subjected to chemotherapy with cisplatin (CP) in clinic. However, the most side effect of CP is nephrotoxicity, which limits the treatment.
Farzaneh Ashrafi +2 more
doaj +1 more source