Results 41 to 50 of about 53,664 (239)
, 2019 Background: If loss of functioning nephrons predisposes to glomerular barotrauma (a “remnant nephron” effect), then glomerular permeability should increase as glomerular filtration rate (GFR) falls, as is observed in animal models of nephron loss ...
Tomson C. (6910280) +5 more
core +1 more source
GLOMERULAR NUMBER AND CAPILLARY DIMENSIONS IN THE NORMAL LAMB KIDNEY
Image Analysis and Stereology, 2011 Reduced nephron endowment, either inherited or acquired, has been linked to adult renal pathology as well as hypertension. The sheep provides an excellent model for studying nephrogenesis and renal development because, as in humans, nephrogenesis is ...
Julian Brown +5 more
doaj +1 more source
Reporter-based fate mapping in human kidney organoids confirms nephron lineage relationships and reveals synchronous nephron formation [PDF]
, 2019 Nephron formation continues throughout kidney morphogenesis in both mice and humans. Lineage tracing studies in mice identified a self-renewing Six2-expressing nephron progenitor population able to give rise to the full complement of nephrons throughout ...
Vanslambrouck, JM +4 more
core +1 more source
ppargc1a controls nephron segmentation during zebrafish embryonic kidney ontogeny
eLife, 2018 Nephron segmentation involves a concert of genetic and molecular signals that are not fully understood. Through a chemical screen, we discovered that alteration of peroxisome proliferator-activated receptor (PPAR) signaling disrupts nephron segmentation ...
Joseph M Chambers +4 more
doaj +1 more source
PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator
Cells, 2020 Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) is perhaps best known as a master regulator of mitochondrial biogenesis and function.
Joseph M. Chambers, Rebecca A. Wingert
doaj +1 more source
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
AGING MEDICINE, EarlyView.Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley +1 more source
The Hippo Pathway in Kidney Development
EncyclopediaThe kidney, a complex organ crucial for a multitude of homeostatic functions, including the maintenance of fluid and electrolyte balance, removal of various metabolic waste products, and hormone production, undergoes intricate developmental processes to ...
Caroline M. Lara +4 more
doaj +1 more source
Seminars in Interventional Radiology, 2014 Renal cell carcinoma (RCC) is a common malignancy with an increasing incidence.1 2 The classic triad of abdominal mass, hematuria, and flank pain accompanied by the various associated paraneoplastic syndromes (or the “internist's tumor”) are rare presentations of contemporary kidney cancer. With the current use and practice of modern abdominal imaging,
Paul, Maroni, Jacob, Moss
openaire +2 more sources
IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis
Arthritis &Rheumatology, EarlyView.Objective Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. IgG from patients with LN displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay +3 more
wiley +1 more source
Anatomical Sciences Education, EarlyView.Abstract Histology is a visually complex and cognitively demanding subject often perceived as abstract, memorization‐heavy, and disconnected from clinical practice. Despite its foundational importance, histology is frequently under‐emphasized relative to gross anatomy and lacks interactive, multimodal resources tailored to its unique challenges.
Anika Knowles +2 more
wiley +1 more source