Results 61 to 70 of about 53,664 (239)
Nephron segment-specific gene expression using AAV vectors. [PDF]
, 2018 AAV9 vector provides efficient gene transfer in all segments of the renal nephron, with minimum expression in non-renal cells, when administered retrogradely via the ureter.
Konkalmatt, Prasad R +11 more
core +1 more source
Food Safety and Health, EarlyView.Withania somnifera seed extract and powder improved metabolic parameters in rats, particularly at higher extract doses, without evident hepatic, renal, hematological, or histopathological toxicity. Molecular docking further predicted strong DPP‐4 inhibitory potential of withanone, supporting the antidiabetic potential of W. somnifera seeds.
Muhammad Usman Khalid +8 more
wiley +1 more source
Biomedicines, 2022 Knowledge about the genetic pathways that control nephron development is essential for better understanding the basis of congenital malformations of the kidney.
Bridgette E. Drummond +10 more
doaj +1 more source
Nephron-sparing Surgery without Angioembolization in Giant Angiomyolipoma: Is it Feasible? [PDF]
, 2018 Varying sizes of renal angiomyolipoma (AML) have been reported in the literature, with the general consensus that a size greater than 10 cm can be termed a giant AML. Our patient presented with increasing abdomen girth since last 3 years.
Ankur Arya +3 more
core +1 more source
The womb as the cradle of longevity: Perinatal origins of biological aging
International Journal of Gynecology &Obstetrics, EarlyView.Abstract The perinatal period is increasingly recognized as an important determinant of biological aging trajectories and disease susceptibility across the lifespan. This narrative review synthesizes current evidence linking intrauterine exposures to adult health outcomes across three biological dimensions: fetal programming, maternal influences, and ...
Sevim Ozge Ozdemir, Ebru Davutoglu
wiley +1 more source
Impact of preterm birth on kidney health and development
Frontiers in MedicinePreterm birth, defined as birth before the gestational age of 37 weeks, affects 11% of the newborns worldwide. While extensive research has focused on the immediate complications associated with prematurity, emerging evidence suggests a link between ...
Sara Deffrennes +9 more
doaj +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential
iNew Medicine, EarlyView.ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang +5 more
wiley +1 more source
Evaluation of the nephrons number in children with congenital pathology of the cardiovascular system
Известия высших учебных заведений. Поволжский регион: Медицинские науки, 2023 Background. The purpose of the study is to determine the dynamics of growth and differentiation of cortical and perimedullary nephrons in children with pathology of the cardiovascular system. Materials and methods.
A.A. Sologub +3 more
doaj +1 more source
Med Research, EarlyView.This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng +14 more
wiley +1 more source