Results 31 to 40 of about 53,664 (239)

Molecular and morphological investigations on the renal mechanisms enabling euryhalinity of red stingray Hemitrygon akajei

Frontiers in Physiology, 2022
Most cartilaginous fishes live in seawater (SW), but a few exceptional elasmobranchs (sharks and rays) are euryhaline and can acclimate to freshwater (FW) environments. The plasma of elasmobranchs is high in NaCl and urea concentrations, which constrains
Naotaka Aburatani, Wataru Takagi, Marty Kwok-Shing Wong, Marty Kwok-Shing Wong, Shigehiro Kuraku, Shigehiro Kuraku, Shigehiro Kuraku, Chiharu Tanegashima, Mitsutaka Kadota, Kazuhiro Saito, Waichiro Godo, Tatsuya Sakamoto, Susumu Hyodo   +12 more
doaj   +1 more source

Novel Concepts in Nephron Sodium Transport:A Physiological and Clinical Perspective

, 2023
The kidneys play a critical role in maintaining total body sodium (Na+) balance across a wide range of dietary intake, accomplished by a concerted effort involving multiple Na+ transporters along the nephron.
Hoorn, Ewout J.; id_orcid, Sparks, Matthew A., Rianto, Fitra, Van Beusecum, Justin P., Ramkumar, Nirupama, Kirabo, Annet, Kon, Valentina, Teakell, Jade, Ewout J. Hoorn, Matthew A. Sparks, Fitra Rianto, Jade Teakell, Justin P. Van Beusecum, Nirupama Ramkumar, Annet Kirabo, Valentina Kon   +15 more
core   +1 more source

Developmental Origins and Nephron Endowment in Hypertension

Frontiers in Pediatrics, 2017
Primary hypertension continues to be one of the main risk factors for cardiovascular disease worldwide. A stable intrauterine environment is critical for the future development and health of the fetus.
Shari Gurusinghe, Anita Tambay, Christine B. Sethna   +2 more
doaj   +1 more source

gldc Is Essential for Renal Progenitor Patterning during Kidney Development

Biomedicines, 2022
The glycine cleavage system (GCS) is a complex located on the mitochondrial membrane that is responsible for regulating glycine levels and contributing one-carbon units to folate metabolism.
Nicole E. Weaver, Allison Healy, Rebecca A. Wingert   +2 more
doaj   +1 more source

The “3Ds” of Growing Kidney Organoids: Advances in Nephron Development, Disease Modeling, and Drug Screening

Cells, 2023
A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in vitro that undergoes self-organization, recapitulating aspects of normal renal development to produce nephron structures that resemble the native kidney organ ...
Brooke E. Chambers, Nicole E. Weaver, Rebecca A. Wingert   +2 more
doaj   +1 more source

NEPHRON NUMBER IN THE OFFSPRING OF RATS FED A LOW PROTEIN DIET DURING PREGNANCY

Image Analysis and Stereology, 2011
In experimental studies it has been shown that intrauterine growth retardation and reduced kidney growth during development are associated with significant decreases in nephron endowment.
Monika A Zimanyi, John F Bertram, Jane M Black   +2 more
doaj   +1 more source

Light and heavy ferritin chain expression in the liver and kidneys of Wistar rats: aging, sex differences, and impact of gonadectomy

Arhiv za Higijenu Rada i Toksikologiju, 2022
Ferritin is the main intracellular storage of iron. Animal studies show that female liver and kidney express more ferritin and accumulate more iron than male. However, no study so far has investigated sex and age differences in light (FtL) and heavy (FtH)
Vulinović Mirela Pavić, Turčić Petra, Micek Vedran, Ljubojević Marija   +3 more
doaj   +1 more source

Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney

Cells, 2023
Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that orchestrate renal progenitor cell fate choices and regulate differentiation.
Hannah M. Wesselman, Allison E. Gatz, Mairead R. Pfaff, Liana Arceri, Rebecca A. Wingert   +4 more
doaj   +1 more source

Role of Tbx2 in defining the territory of the pronephric nephron

, 2011
Despite extensive study of the development of the nephron, which is the functional unit of the kidney, the molecular mechanisms underlying the determination of nephron size remain largely unknown.
Gun-Sik Cho, Sun-Cheol Choi, Jin-Kwan Han, Edmond Changkyun Park   +3 more
core   +2 more sources

Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish

Journal of Developmental Biology, 2023
Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process of blood filtration. Congenital malformation or damage to podocytes has dire consequences and initiates a cascade of pathological changes leading to renal ...
Bridgette E. Drummond, Wesley S. Ercanbrack, Rebecca A. Wingert   +2 more
doaj   +1 more source