Results 241 to 250 of about 452,381 (401)

Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial

open access: yesJournal of the American Medical Association (JAMA), 2017
J. Lv   +26 more
semanticscholar   +1 more source

Pyrroloquinoline Quinone Reprograms the Single‐Cell Landscape of Immune Aging in Hematopoietic Immune System

open access: yesAging Cell, EarlyView.
This study demonstrates that aging induces oxidative stress and inflammation in the hematopoietic immune system, resulting in immune homeostasis dysfunction, including alterations in B cells and hematopoietic stem cells, senescent cells (SnCs) accumulation, and senescence‐associated secretory phenotypes (SASPs) production. Notably, the study highlights
Xiuxing Liu   +11 more
wiley   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

open access: yesAging Cell, EarlyView.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji   +15 more
wiley   +1 more source

Short‐Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study

open access: yesAging Cell, EarlyView.
Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Maria Lastra Cagigas   +16 more
wiley   +1 more source

The Utility of the SUNTRAC Tool in Predicting Skin Cancers in Renal Transplant Patients

open access: yesAustralasian Journal of Dermatology, EarlyView.
ABSTRACT This study evaluates the SUNTRAC tool in guiding initial skin cancer risk stratification among renal transplant patients in New Zealand. Higher retrospectively applied SUNTRAC grades in 219 patients were associated with higher incidence of skin cancer, supporting the tool's effectiveness in guiding initial skin cancer risk stratification in ...
Sarah Seol   +2 more
wiley   +1 more source

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