Results 41 to 50 of about 481,070 (386)

The single-cell transcriptomic landscape of early human diabetic nephropathy

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Single-nucleus RNA sequencing revealed gene expression changes in early diabetic nephropathy that promote urinary potassium secretion and decreased calcium and magnesium reabsorption.
Parker C. Wilson, Haojia Wu, Yuhei Kirita, Kohei Uchimura, Nicolas Ledru, H. Rennke, P. Welling, S. Waikar, B. Humphreys   +8 more
semanticscholar   +1 more source

Complement activation in IgA nephropathy

Seminars in Immunopathology, 2021
IgA nephropathy pathogenesis is incompletely understood, and this limits the development of disease-specific biomarkers and effective therapies. Evidence of complement activity in IgA nephropathy is well established.
N. Medjeral-Thomas, H. Cook, M. Pickering   +2 more
semanticscholar   +1 more source

Angiotensin type-2 (AT-2)-receptor activation reduces renal fibrosis in cyclosporine nephropathy: evidence for blood-pressure independent effect [PDF]

, 2016
Compound 21 (C21), selective agonist of AT2 receptors, shows antinflammatory effects in hypertension and nephroprotection in diabetes. The aim of this study was to evaluate the effects of C21 in cyclosporine nephropathy, which is characterized mainly by ...
Carletti, R, Castoldi, G, DI GIOIA, Cira Rosaria Tiziana, Roma, F, Stella, A., Zerbini, G   +5 more
core   +1 more source

Recurrence of IgA Nephropathy after Kidney Transplantation in Adults

American Society of Nephrology. Clinical Journal, 2021
Visual Abstract Background and objectives In patients with kidney failure due to IgA nephropathy, IgA deposits can recur in a subsequent kidney transplant.
Audrey Uffing, M. Pérez-Sáez, T. Jouvé, Mathilde Bugnazet, P. Malvezzi, S. Muhsin, Marie-Camille Lafargue, R. Reindl-Schwaighofer, Alina Morlock, R. Oberbauer, Anna Buxeda, C. Burballa, J. Pascual, S. von Moos, H. Seeger, G. La Manna, G. Comai, C. Bini, Luis Sanchez Russo, Samira S. Farouk, Pitchaphon Nissaisorakarn, Het Patel, N. Agrawal, G. Mastroianni-Kirsztajn, Juliana Mansur, H. Tedesco-Silva, C. Ventura, F. Agena, E. David‐Neto, E. Akalin, Omar Alani, M. Mazzali, R. Manfro, A. Bauer, Aileen X Wang, X. Cheng, Jesse D. Schold, S. Berger, P. Cravedi, Leonardo V. Riella   +39 more
semanticscholar   +1 more source

Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy [PDF]

, 2017
Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly ...
Bascands, Jean-Loup, Delles, Christian, Denis, Colette, Husi, Holger, Klein, Julie, Kontostathi, Georgia, Krochmal, Magdalena, Leierer, Johannes, Magalhães, Pedro, Makridakis, Manousos, Mayer, Gert, Mischak, Harald, Schanstra, Joost P., Vlahou, Antonia, Zoidakis, Jerome, Zürbig, Petra   +15 more
core   +2 more sources

Renal AA-amyloidosis in intravenous drug users - a role for HIV-infection? [PDF]

, 2012
Background: Chronic renal disease is a serious complication of long-term intravenous drug use (IVDU). Recent reports have postulated a changing pattern of underlying nephropathy over the last decades.
Amann, Kerstin Ute, Betz, Christoph, Bickel, Markus, Büttner, Maike, Grützmacher, Peter, Haack, Hans Stefan, Jung, Oliver, Stephan, Christoph   +7 more
core   +2 more sources

Update on Diabetic Nephropathy: Core Curriculum 2018.

American Journal of Kidney Diseases, 2018
Diabetic kidney disease and diabetic nephropathy are the leading cause of end-stage kidney disease in the United States and most developed countries. Diabetes accounts for 30% to 50% of the incident cases of end-stage kidney disease in the United States.
K. Umanath, J. Lewis
semanticscholar   +1 more source

Inflammatory Targets in Diabetic Nephropathy

Journal of Clinical Medicine, 2020
One of the most frequent complications in patients with diabetes mellitus is diabetic nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and the main cause of cardiovascular morbidity and mortality in these patients.
J. Donate-Correa, D. Luis-Rodríguez, E. Martín-Núñez, VICTOR GARCIA TAGUA, C. Hernández-Carballo, C. Ferri, A. E. Rodríguez-Rodríguez, C. Mora-Fernández, J. Navarro-González   +8 more
semanticscholar   +1 more source

Macrophage Phenotype and Fibrosis in Diabetic Nephropathy

International Journal of Molecular Sciences, 2020
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease globally. The primary initiating mechanism in DN is hyperglycemia-induced vascular dysfunction, but its progression is due to different pathological mechanisms, including oxidative
Priscila Calle, G. Hotter
semanticscholar   +1 more source

Critical Role of Cysteine-Rich Protein 61 in Mediating the Activation of Renal Fibroblasts

Frontiers in Physiology, 2019
ObjectiveTo explore the expression of cysteine-rich protein 61 (Cyr61) in ischemic renal fibrosis and the role of Cyr61 in mediating the activation of renal fibroblasts.Methods(1) The rat model of renal fibrosis was established after ischemia-reperfusion
Hang Liu, Long Zhao, Jisheng Zhang, Chenyu Li, Xuefei Shen, Xuemei Liu, Wei Jiang, Congjuan Luo, Yanfei Wang, Lin Che, Yan Xu   +10 more
doaj   +1 more source