Results 31 to 40 of about 306,712 (215)
Identification of Genes Reveals the Mechanism of Cell Ferroptosis in Diabetic Nephropathy
Frontiers in Physiology, 2022 Aims/Introduction: Diabetic nephropathy (DN) is one of the main complications of diabetes. Genomics may reveal the essential pathogenesis of DN. We analyzed datasets to search for key genes to explore pathological mechanisms of DN.Materials and Methods ...
Xian Wang +11 more
doaj +1 more source
High glucose up-regulates ENaC and SGK1 expression in HCD-cells [PDF]
, 2006 Background/Aim: Diabetic nephropathy is associated with progressive renal damage, leading to impaired function and end-stage renal failure. Secondary hypertension stems from a deranged ability of cells within the kidney to resolve and appropriately ...
Bell LM +30 more
core +1 more source
Ameliorative role of SIRT1 in peritoneal fibrosis: an in vivo and in vitro study
Cell & Bioscience, 2021 Background Peritoneal fibrosis is one of the major complications induced by peritoneal dialysis (PD). Damaged integrity and function of peritoneum caused by peritoneal fibrosis not only limits the curative efficacy of PD and but affects the prognosis of ...
Yanhong Guo +7 more
doaj +1 more source
Environmental Health Perspectives, 1976 The purpose of this paper is to review the development of the mammalian kidney and to assess the influence that various perinatal manipulations may have on the developmental process either morphologically or functionally. Immature kidneys in general have less functional capacity than adult kidneys and a low rate of glomerular filtration, perhaps ...
openaire +2 more sources
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
core +1 more source
Critical Role of Cysteine-Rich Protein 61 in Mediating the Activation of Renal Fibroblasts
Frontiers in Physiology, 2019 ObjectiveTo explore the expression of cysteine-rich protein 61 (Cyr61) in ischemic renal fibrosis and the role of Cyr61 in mediating the activation of renal fibroblasts.Methods(1) The rat model of renal fibrosis was established after ischemia-reperfusion
Hang Liu +10 more
doaj +1 more source
Dietary interventions to contrast the onset and progression of diabetic nephropathy. a critical survey of new data [PDF]
, 2017 This article is a critical overview of recent contributions on the dietary corrections and the foods that have been claimed to delay or hinder the onset of diabetic nephropathy (DN) and its progression to end-stage renal disease.
Iacobini, Carla +3 more
core +1 more source
Stem Cell Research & Therapy, 2020 Introduction Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis (PD). Combination therapies are emerging as a promising treatment for tissue damage.
Yanhong Guo +6 more
doaj +1 more source
Preoperative proteinuria may be a risk factor for postoperative acute kidney injury：a meta-analysis
Renal Failure, 2021 Objective To investigate the relationship between preoperative proteinuria and postoperative acute kidney injury (AKI). Methods We performed a search on databases included PubMed, Embase, the Cochrane Library, and Web of Science, from December 2009 to ...
Dan-Dan Huang +3 more
doaj +1 more source
Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease
Frontiers in Pharmacology, 2022 Necroptosis was elevated in both tubulointerstitial and glomerular renal tissue in patients with diabetic kidney disease (DKD), and was most pronounced on glomerulus in the stage with macroalbuminuria. This study further explored whether paeoniflorin (PF)
Xian Wang +8 more
doaj +1 more source