Results 91 to 100 of about 72,055 (308)
Cancer Management and Research, 2021 John Isiiko,1– 3 Barnabas Atwiine,4 Joseph Oloro5 1Department of Pharmacy, Mbarara University of Science and Technology, Mbarara, Uganda; 2Pharmacy Biotechnology and Traditional Medicine Center, Mbarara University of Science and Technology, Mbarara ...
Isiiko J, Atwiine B, Oloro J
doaj
Renal Failure, 1999 Tacolimus (FK506) is a potent immunosuppressive agent with significant nephrotoxic properties. FK506 is complexed with an intracellular binding protein FKBP-12. Both the immunosuppressive and nephrotoxic effects may be linked to the inhibitory effect of this complex on calcineurin.
openaire +2 more sources
Animal Models and Experimental Medicine, EarlyView.This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji +2 more
wiley +1 more source
Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo [PDF]
, 2018 Mohamed Anwar K Abdelhalim, Huda AY Qaid, Yanallah Al-Mohy, Mohammed Suliman Al-Ayed Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia Introduction: This study aimed to evaluate the nephrotoxicity ...
Qaid HAY +3 more
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Concomitant gentamicin‑induced nephrotoxicity and bilateral ototoxicity [PDF]
, 2016 Co‑occurrence of aminoglycoside‑induced ototoxicity and nephrotoxicity is rare, possibly as a result of divergent mechanisms of tissue damage despite similarities in the anatomy of the inner ear and the proximal renal tubular epithelium.
Akinbodewa, AA, Okunola, O
core +2 more sources
Arthritis &Rheumatology, EarlyView.Objective Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardiovascular (CV) complications and lupus nephritis (LN) remain leading causes of morbidity and mortality. This study investigated whether omic profiling can reveal molecular endotypes linked to these outcomes.
Tomás Cerdó +84 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia +16 more
wiley +1 more source
Aminoglycoside-induced nephrotoxicity in children [PDF]
, 2016 Aminoglycoside antibiotics, in particular gentamicin and tobramycin, are still commonly used in paediatric clinical practice. These drugs cause nephrotoxicity, which particularly affects the proximal tubule epithelial cells due to selective endocytosis ...
McWilliam, SJ +7 more
core +1 more source
Metabolomic investigation of cisplatin‐induced acute kidney injury in paediatric cancer patients
British Journal of Clinical Pharmacology, EarlyView.Aim Cisplatin causes acute kidney injury (AKI) in approximately 46% of paediatric cancer patients who receive it. Serum creatinine (SCr) is a poor biomarker of cisplatin nephrotoxicity, because there is a delay between cisplatin infusion and SCr elevation.
Yong Jin Lim +37 more
wiley +1 more source
Vancomycin-associated nephrotoxicity, a case control study [PDF]
, 2015 Background: Vancomycin is a cornerstone antibiotic for the management of severe Gram positive infections. However, high doses of vancomycin are associated with a risk of nephrotoxicity.
Cerruti, J.
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