Results 101 to 110 of about 72,055 (308)

Evaluation of protective efficacy of flaxseed lignan-Secoisolariciresinol diglucoside against mercuric chloride-induced nephrotoxicity in rats [PDF]

, 2019
The toxicity of heavy metals such as mercury (Hg) in humans and animals is well documented. The kidney is the primary deposition site of inorganic-Hg and target organ of its toxicity.
Javaraiah, R, Aqeel, T, Chikkalakshmipura Gurumallu, S, AlQurashi, N, Hashimi, SM   +4 more
core   +1 more source

Assessment of osteopontin as an early nephrotoxicity indicator in human renal proximal tubule cells and its application in evaluating lanthanum-induced nephrotoxicity

Ecotoxicology and Environmental Safety
Nephrotoxicity is a common adverse effect induced by various chemicals, necessitating the development of reliable toxicity screening models for nephrotoxicity assessment.
Yingsi Chen, Feifei Xu, Xiaoxuan Xiao, Huiqin Chi, Yuefei Lai, Xiuqin Lin, Qiuyun Li, Jia Song, Weiliang Wu, Ziyin Li, Xingfen Yang   +10 more
doaj   +1 more source

Evaluation of Risk Factors for Intravenous Colistin Use-related Nephrotoxicity

Oman Medical Journal, 2016
Objectives: We investigated the incidence of and risk factors for nephrotoxicity in patients using intravenous colistin. Methods: This retrospective, observational study was conducted at Karadeniz Technical University, Faculty of Medicine, clinics and ...
Iftihar Koksal, Selcuk Kaya, Eda Gencalioglu, Gurdal Yilmaz   +3 more
doaj   +1 more source

Supratherapeutic drug concentration triggers: A novel data‐driven approach to assess their value for medication safety surveillance in intensive care

British Journal of Clinical Pharmacology, EarlyView.
Aims Electronic triggers (e‐triggers) are used as screening signals to detect potential adverse drug events (ADEs) and offer an effective system level approach for medication safety surveillance. Their clinical utility is typically evaluated through time‐consuming manual chart review by experts, limiting implementation.
Anne Paulien Langermans, Izak A. R. Yasrebi‐de Kom, Dylan Wayne de Lange, Nicolette Fransisca de Keizer, Joanna E. Klopotowska, on behalf of the RESCUE Study group, C. S. C. Bouman, E. N. van Roon, P. F. Schutte, J. ten Cate, D. van Balen, S. Hendriks, C. Lau, W. J. Vermeijden, A. Beishuizen, J. B. Masselink, P. E. Spronk, H. J. M. van Kan, P. W. de Feiter, E. J. Wils, A. Wieringa, A. J. Valkenburg, W. M. van den Bergh, M. H. Renes, W. Bult, E. de Jonge, M. Hoeksema, E. J. Wesselink, I. M. Purmer, B. E. Bosma, S. H. W. van Bree, H. J. W. Lammers, R. J. Bosman, E. J. F. Franssen, A. Karakus, M. Sigtermans, E. M. Kuck, D. A. Dongelmans, M. J. H. Aries, E. V. Uijtendaal, M. C. Reuland   +40 more
wiley   +1 more source

Lipid imaging for visualizing cilastatin amelioration of cisplatin-induced nephrotoxicity [PDF]

, 2018
Nephrotoxicity is a major limitation to cisplatin antitumor therapies. Cilastatin, an inhibitor of renal dehydropeptidase-I, was recently proposed as a promising nephroprotector against cisplatin toxicity, preventing apoptotic cell death.
Linscheid, Michael W., Aboulmagd, Sarah, Moreno Gordaliza, María Estefanía, Lázaro Fernández, Alberto, Humanes, Blanca, Esteban Fernández, Diego, Gómez Gómez, María Milagros   +6 more
core   +2 more sources

Aminoglycosides: Nephrotoxicity [PDF]

Antimicrobial Agents and Chemotherapy, 1999
M P, Mingeot-Leclercq, P M, Tulkens
openaire   +2 more sources

Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis

British Journal of Clinical Pharmacology, EarlyView.
Intravenous tobramycin is a first‐line treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF). Tobramycin exhibits concentration‐dependent activity; however, excess drug exposure can lead to nephrotoxicity and ototoxicity. While dosing typically targets serum peak (Cmax) and trough (Cmin) concentrations, the area under the ...
Kiera H. Harwood, Sarah Bannister, Stephen Duffull, April Martinez, Sarath Ranganathan, Shivanthan Shanthikumar, Amanda Gwee   +6 more
wiley   +1 more source

Renal biomarkers predict nephrotoxicity after paraquat [PDF]

, 2013
Drug-induced nephrotoxicity contributes to the failure rate of investigational drugs during clinical trials. We are still not able to accurately predict drug-induced nephrotoxicity during early drug discovery and development.
Grice, Jeffrey E., Buckley, Nicholas A., Endre, Zoltan, Peake, Philip, Gobe, Glenda, Roberts, Michael S., Liu, Xin, Wunnapuk, Klintean   +7 more
core   +1 more source

Single high dose gentamicin for perioperative prophylaxis in orthopedic surgery: Evaluation of nephrotoxicity

SAGE Open Medicine, 2015
Background: Recent studies described an increase in acute kidney injury when high dose gentamicin was included in perioperative prophylaxis for orthopedic surgeries. To this effect, we compared the rate of nephrotoxicity for selected orthopedic surgeries
Yanina Dubrovskaya, Rainer Tejada, Joseph Bosco, Anna Stachel, Donald Chen, Melinda Feng, Andrew Rosenberg, Michael Phillips   +7 more
doaj   +1 more source

Impact of cumulative glucocorticoid exposure on vancomycin clearance in hospitalized children: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Prior glucocorticoid exposure is associated with modestly increased vancomycin clearance in hospitalized children, partly mediated by renal function and inflammation and may contribute to subtherapeutic early drug exposure. Abstract Introduction Augmented renal clearance (ARC) can lead to subtherapeutic vancomycin exposure in children.
Kouki Tomari, Ruud H. J. Verstegen, Cintia Cruz, Erin Chung, Aleena Azim, Shinya Ito, Tamorah R. Lewis   +6 more
wiley   +1 more source