Results 11 to 20 of about 111,114 (198)

Unveiling the mechanisms of nephrotoxicity caused by nephrotoxic compounds using toxicological network analysis

Molecular Therapy: Nucleic Acids, 2023
Billions of people worldwide have experienced irreversible kidney injuries, which is mainly attributed to the complexity of drug-induced nephrotoxicity.
Kexing Xi, Mengqing Zhang, Mingrui Li, Qiang Tang, Qi Zhao, Wei Chen   +5 more
doaj   +1 more source

Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence

International Journal of Molecular Sciences, 2021
Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them.
Chong-Sun Khoi, Jia-Huang Chen, Tzu-Yu Lin, C. Chiang, K. Hung   +4 more
semanticscholar   +1 more source

Comparison of Myelotoxicity and Nephrotoxicity Between Daily Low-Dose Cisplatin With Concurrent Radiation and Cyclic High-Dose Cisplatin in Non-Small Cell Lung Cancer Patients

Frontiers in Pharmacology, 2020
AimAntineoplastic effect of cisplatin, the first line treatment in non-small cell lung cancer (NSCLC), is hindered by its nephrotoxicity and myelotoxicity. Both low-dose and high-dose regimens are used in the management of NSCLC. The aim of this study is
Zulfan Zazuli, Zulfan Zazuli, Renate Kos, Joris D. Veltman, Wilma Uyterlinde, Cristina Longo, Paul Baas, Rosalinde Masereeuw, Susanne J. H. Vijverberg, Anke-Hilse Maitland-van der Zee   +9 more
doaj   +1 more source

Nephrotoxicity from Vancomycin Combined with Piperacillin-Tazobactam: A Comprehensive Review

American Journal of Nephrology, 2021
Background: Recent studies have identified the combination of vancomycin with piperacillin-tazobactam (VPT) to be associated with increased nephrotoxicity.
M. Blair, J. Côté, A. Cotter, B. Lynch, L. Redahan, P. Murray   +5 more
semanticscholar   +1 more source

Inhibition of gentamicin–induced renal tubular cell necrosis [PDF]

Journal of Nephropathology, 2012
Gentamicin nephrotoxicity limit its usage against gram negative bacteria. Most researches showed that antioxidant agents improved gentamicin nephrotoxicity.
Majid Tavafi
doaj   +1 more source

Bibliometric and visual analysis of nephrotoxicity research worldwide

Frontiers in Pharmacology, 2022
Background: Nephrotoxicity of drugs contributes to acute kidney injury with high mortality and morbidity, which crucially limits the application and development of drugs.
Tianmu He, Tianmu He, Jingwen Ao, Cancan Duan, Rong Yan, Xiaomei Li, Liu Liu, Jianyong Zhang, Xiaofei Li, Xiaofei Li   +9 more
doaj   +1 more source

Mechanism and reversal of drug-induced nephrotoxicity on a chip

Science Translational Medicine, 2021
Sensor-embedded spheroids-on-a-chip reveal the mechanisms of cisplatin- and cyclosporine-induced nephrotoxicity and identify a potential therapeutic.
Aaron Cohen, K. Ioannidis, A. Ehrlich, Shaun Regenbaum, Merav Cohen, M. Ayyash, Sigal Shafran Tikva, Y. Nahmias   +7 more
semanticscholar   +1 more source

Prospective observational study of the impact of plasma colistin levels in patients with carbapenem-resistant Acinetobacter baumannii pneumonia

Journal of Global Antimicrobial Resistance, 2021
: Objectives: Colistin, an important drug to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections, has a narrow therapeutic window with nephrotoxicity.
Yun-Jeong Jeong, Namyi Gu, Won Gun Kwack, Yunseong Kang, Seong Yeon Park, Young-Soon Yoon   +5 more
doaj   +1 more source

Colistin Nephrotoxicity: Meta-Analysis of Randomized Controlled Trials

Open Forum Infectious Diseases, 2021
Background Nephrotoxicity is a known adverse effect of polymyxin antibiotics, including colistin. Although previous meta-analyses have aimed to characterize colistin-associated nephrotoxicity risk relative to other antibiotics, included studies were ...
K. Eljaaly, Monique R Bidell, R. Gandhi, S. Alshehri, M. Enani, A. Al-jedai, T. Lee   +6 more
semanticscholar   +1 more source

Comparison of colistin-induced nephrotoxicity between two different formulations of colistin in critically ill patients: a retrospective cohort study

Antimicrobial Resistance and Infection Control, 2021
Background Colistin is widely used in the treatment of nosocomial infections caused by carbapenem-resistant gram-negative bacilli (CR-GNB). Colistin-induced nephrotoxicity is one of the major adverse reactions during colistin treatment.
Jia-Yih Feng, Yi-Tzu Lee, Sheng-Wei Pan, Kuang-Yao Yang, Yuh-Min Chen, David Hung-Tsang Yen, Szu-Yuan Li, Fu-Der Wang   +7 more
doaj   +1 more source