Results 31 to 40 of about 111,114 (198)

A Novel Dipeptidyl Peptidase-4 Inhibitor DA-1229 Ameliorates Tubulointerstitial Fibrosis in Cyclosporine Nephrotoxicity in Mice

Life, 2021
Cyclosporine A (CyA) is an immunosuppressive agent that induces nephrotoxicity with long-term treatment. The roles of DPP-4 and its inhibitors in cyclosporine nephrotoxicity are not fully understood.
Hye Sook Min, Ji Eun Lee, Jung Yeon Ghee, Young Sun Kang, Jin Joo Cha, Jee Young Han, Sang Youb Han, Dae Ryong Cha   +7 more
doaj   +1 more source

Nephrotoxicity of immune checkpoint inhibitors beyond tubulointerstitial nephritis: single-center experience

Journal of Immunotherapy for Cancer, 2019
Rationale & ObjectiveThe approved therapeutic indication for immune checkpoint inhibitors (CPIs) are rapidly expanding including treatment in the adjuvant setting, the immune related toxicities associated with CPI can limit the efficacy of these agents ...
Omar Mamlouk, U. Selamet, Shana M Machado, M. Abdelrahim, W. Glass, A. Tchakarov, L. Gaber, Amit Lahoti, Biruh T. Workeneh, Sheldon Chen, Jamie S. Lin, N. Abdel-Wahab, J. Tayar, Huifang Lu, M. Suarez‐Almazor, N. Tannir, C. Yee, A. Diab, Ala Abudayyeh   +18 more
semanticscholar   +1 more source

Kaempferol ameliorates Cisplatin induced nephrotoxicity by modulating oxidative stress, inflammation and apoptosis via ERK and NF-κB pathways

AMB Express, 2020
Anticancer drug like Cisplatin are associated with serious problem like nephrotoxicity. The effect of Kaempferol is a plant-derived flavonoid compound.
Zhu Wang, Wan-sen Sun, Xi Sun, Ye Wang, Meilan Zhou   +4 more
semanticscholar   +1 more source

P-Glycoprotein Induction Ameliorates Colistin Induced Nephrotoxicity in Cultured Human Proximal Tubular Cells. [PDF]

PLoS ONE, 2015
The pathogenesis of colistin induced nephrotoxicity is poorly understood. Currently there are no effective therapeutic or prophylactic agents available.
Sun-hyo Lee, Jin-sun Kim, Kameswaran Ravichandran, Hyo-Wook Gil, Ho-yeon Song, Sae-yong Hong   +5 more
doaj   +1 more source

Efficient Drug Screening and Nephrotoxicity Assessment on Co-culture Microfluidic Kidney Chip

Scientific Reports, 2020
The function and susceptibility of various drugs are tested with renal proximal tubular epithelial cells; yet, replicating the morphology and kidneys function using the currently available in vitro models remains difficult.
L. Yin, Guanru Du, Bing Zhang, Hongbo Zhang, R. Yin, Wenjun Zhang, Shih-Mo Yang   +6 more
semanticscholar   +1 more source

Selenium alleviates porcine nephrotoxicity of ochratoxin A by improving selenoenzyme expression in vitro. [PDF]

PLoS ONE, 2015
Ochratoxin A (OTA), a mycotoxin, is a potent nephrotoxin in humans and animals. Selenium (Se) is an essential micronutrient for humans and animals, and plays a key role in antioxidant defense.
Fang Gan, Hongxia Xue, Yu Huang, Cuiling Pan, Kehe Huang   +4 more
doaj   +1 more source

Colistin-induced Nephrotoxicity: Experience from a University Hospital

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2021
Introduction: Colistin has been widely used in the treatment of infections caused by multidrug-resistant bacteria. This study aimed to determine the frequency and risk factors of colistin-related nephrotoxicity.
Pınar BAKIR EKİNCİ, Melek KURTARAN, Emre KARA, Hanife AVCI, Kutay DEMİRKAN, Gökhan METAN   +5 more
doaj   +1 more source

Aristolochic Acid-Induced Nephrotoxicity: Molecular Mechanisms and Potential Protective Approaches

International Journal of Molecular Sciences, 2020
Aristolochic acid (AA) is a generic term that describes a group of structurally related compounds found in the Aristolochiaceae plants family. These plants have been used for decades to treat various diseases. However, the consumption of products derived
Etienne Empweb Anger, F. Yu, Ji Li
semanticscholar   +1 more source

Role of probiotics in the management of cisplatin-induced nephrotoxicity

Medicine in Microecology
New research shows that gut microbes have a role in the management of cisplatin-induced nephrotoxicity, with underlying processes involving mucosal and/or systemic inflammation or metabolic abnormalities.
Serina Easmin, Moulik Bhattacharyya, Krishna Pal, Priya Das, Ranabir Sahu, Gouranga Nandi, Paramita Paul, Tarun Kumar Dua   +7 more
doaj   +1 more source

Concomitant palonosetron ameliorates cisplatin-induced nephrotoxicity, nausea, and vomiting: a retrospective cohort study and pharmacovigilance analysis

Journal of Pharmaceutical Health Care and Sciences, 2022
Background Cisplatin (CDDP)-induced nephrotoxicity is the most important complication of CDDP treatment. 5-Hydroxytryptamine type 3 receptor antagonists (5-HT3RAs) are widely used to prevent chemotherapy-induced nausea and vomiting (CINV).
Miho Takemura, Kenji Ikemura, Masayoshi Kondo, Fumihiro Yamane, Mikiko Ueda, Masahiro Okuda   +5 more
doaj   +1 more source