Determination of colistin-related nephrotoxicity and risk factors in intensive care unit
İstanbul Kuzey Klinikleri, 2018 INTRODUCTION[|]Colistin is a cationic polypeptide antibiotic with a cyclic structure that belongs to the polymyxin group. It was banned from clinical use because of its significant renal side effects, such as nephrotoxicity.
Ayse Inci +4 more
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Experimental Cell Line Models for Nephrotoxicity Screening
Регуляторные исследования и экспертиза лекарственных средств, 2021 The aim of the study was to review literature data on cell models for experimental assessment of drug nephrotoxicity in vitro. Because of nephrotoxicity, 2% of new investigational medicinal products are discarded at the stage of preclinical in vivo ...
I. A. Mazerkina +4 more
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Pilot trial of fk 506 in the management of steroid-resistant nephrotic syndrome [PDF]
, 1993 Seven patients with steroid-resistant nephrotic syndrome were treated with FK 506 monotherapy. Four patients were children with focal sclerosing glomerulonephritis (FSGS).
Ellis, D +9 more
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Predictive usefulness of urinary biomarkers for the identification of cyclosporine A-induced nephrotoxicity in a rat model. [PDF]
PLoS ONE, 2014 The main side effect of cyclosporine A (CsA), a widely used immunosuppressive drug, is nephrotoxicity. Early detection of CsA-induced acute nephrotoxicity is essential for stop or minimize kidney injury, and timely detection of chronic nephrotoxicity is ...
Carla Patrícia Carlos +3 more
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Life, 2021 Cyclosporine A (CyA) is an immunosuppressive agent that induces nephrotoxicity with long-term treatment. The roles of DPP-4 and its inhibitors in cyclosporine nephrotoxicity are not fully understood.
Hye Sook Min +7 more
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Methoxyflurane nephrotoxicity [PDF]
Canadian Anaesthetists’ Society Journal, 1974 Methoxyflurane used as an anaesthetic even in low doses can cause renal dysfunction. We suggest that the drug be abandoned.
openaire +2 more sources
Canine liver transplantation under nva cyclosporine versus cyclosporine [PDF]
, 1986 The immunosuppressive qualities and other features of a new cyclosporine (CsA) analogue, Nva 2-cyclosporine (Nva 2-CsA) were examined using canine orthotopic liver allografts.
DeWolf, A +6 more
core +1 more source
P-Glycoprotein Induction Ameliorates Colistin Induced Nephrotoxicity in Cultured Human Proximal Tubular Cells. [PDF]
PLoS ONE, 2015 The pathogenesis of colistin induced nephrotoxicity is poorly understood. Currently there are no effective therapeutic or prophylactic agents available.
Sun-hyo Lee +5 more
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Colistin-induced Nephrotoxicity: Experience from a University Hospital
Mediterranean Journal of Infection, Microbes and Antimicrobials, 2021 Introduction: Colistin has been widely used in the treatment of infections caused by multidrug-resistant bacteria. This study aimed to determine the frequency and risk factors of colistin-related nephrotoxicity.
Pınar BAKIR EKİNCİ +5 more
doaj +1 more source
Selenium alleviates porcine nephrotoxicity of ochratoxin A by improving selenoenzyme expression in vitro. [PDF]
PLoS ONE, 2015 Ochratoxin A (OTA), a mycotoxin, is a potent nephrotoxin in humans and animals. Selenium (Se) is an essential micronutrient for humans and animals, and plays a key role in antioxidant defense.
Fang Gan +4 more
doaj +1 more source