Results 41 to 50 of about 111,114 (198)

Comparison of nephrotoxicity of Colistin with Polymyxin B administered in currently recommended doses: a prospective study

Annals of Clinical Microbiology and Antimicrobials, 2018
Background The most important concern with polymyxins (Colistin and Polymyxin B) use is nephrotoxicity. There is no prospective data comparing nephrotoxicity of these two drugs, when administered in high doses and as per current recommendations.
Ritesh Aggarwal, Arun Dewan
doaj   +1 more source

Effectiveness and Nephrotoxicity of Intravenous Polymyxin B in Chinese Patients With MDR and XDR Nosocomial Pneumonia

Frontiers in Pharmacology, 2021
Background: Nosocomial pneumonia is a major health and economic burden globally. Multidrug-resistant (MDR) or extensively drug-resistant (XDR) Gram-negative bacteria are the most common causative pathogens in critically-ill patients.
Huihui Zeng, Huihui Zeng, Huihui Zeng, Zihang Zeng, Zihang Zeng, Zihang Zeng, Xianglong Kong, Hongliang Zhang, Ping Chen, Ping Chen, Ping Chen, Hong Luo, Hong Luo, Hong Luo, Yan Chen, Yan Chen, Yan Chen   +16 more
doaj   +1 more source

Molecular Mechanisms of Colistin-Induced Nephrotoxicity

Molecules, 2019
The emergence of multidrug resistant (MDR) infections and the shortage of new therapeutic options have made colistin, a polymyxin antibiotic, the main option for the treatment of MDR Gram-negative bacterial infections in the last decade.
Z. Gai, Sophia L. Samodelov, G. Kullak-Ublick, M. Visentin   +3 more
semanticscholar   +1 more source

Factors associated with chronic calcineurin inhibitor nephrotoxicity in children with minimal-change disease

Renal Failure
Background Calcineurin inhibitors (CNIs), such as cyclosporine (CsA) and tacrolimus (TAC), are commonly used to treat children with complicated minimal change nephrotic syndrome.
Bei Jin, Ziji Lu, Cheng Cheng, Yuxin Pei, Lizhi Chen, Zhihui Yue, Aihua Lin, Shicong Yang, Ying Mo, Xiaoyun Jiang   +9 more
doaj   +1 more source

Drug-induced nephrotoxicity.

Revista da Associação Médica Brasileira, 2020
Acute kidney injury is a very common diagnosis, present in up to 60% of critical patients, and its third main cause is drug toxicity. Nephrotoxicity can be defined as any renal injury caused directly or indirectly by medications, with acute renal failure,
G. T. M. Sales, R. D. Foresto
semanticscholar   +1 more source

Association of high intra-patient variability in tacrolimus exposure with calcineurin inhibitor nephrotoxicity in kidney transplantation

Scientific Reports, 2023
Tacrolimus intra-patient variability (IPV) is a novel predictive marker for long-term kidney transplantation outcomes. We examined the association between IPV and calcineurin inhibitor (CNI) nephrotoxicity and the impact of pharmacogenes on CNI ...
Hyokee Kim, Ahram Han, Sanghyun Ahn, Seung-Kee Min, Jongwon Ha, Sangil Min   +5 more
doaj   +1 more source

Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1–PGC-1α pathway activation

Ecotoxicology and Environmental Safety, 2022
Melatonin is an indoleamine produced in the pineal gland and has many physiological roles. There is increasing evidence that melatonin ameliorates cadmium (Cd)-induced nephrotoxicity.
Wenxuan Dong, Lianqi Yan, Yun Tan, Shufang Chen, Kanglei Zhang, Zhonggui Gong, Wenjing Liu, Hui Zou, Ruilong Song, Jiaqiao Zhu, Gang Liu, Zongping Liu   +11 more
doaj   +1 more source

The Nephrotoxicity of Vancomycin

Clinical pharmacology and therapy, 2017
Vancomycin use is often associated with nephrotoxicity. It remains uncertain, however, to what extent vancomycin is directly responsible, as numerous potential risk factors for acute kidney injury frequently coexist.
E. Filippone, W. Kraft, J. Farber
semanticscholar   +1 more source

A Review of Nephrotoxicity of Microcystins

Toxins, 2020
Cyanobacterial blooms triggered by eutrophication and climate change have become a global public health issue. The toxic metabolites microcystins (MCs) generated by cyanobacteria can accumulate in food chain and contaminate water, thus posing a potential
Shuaishuai Xu, Xiping Yi, Wenya Liu, Chengcheng Zhang, I. Massey, Fei Yang, Li Tian   +6 more
semanticscholar   +1 more source

Urine kidney injury molecule-1 predicts subclinical kidney disease among persons living with HIV initiating tenofovir disoproxil fumarate-based ART in Zambia

Frontiers in Nephrology
IntroductionAntiretroviral therapy (ART) increases the life expectancy of persons living with HIV (PLWH), but not without potentially serious adverse effects.
Freeman W. Chabala, Edward D. Siew, Edward D. Siew, Edward D. Siew, C. William Wester, C. William Wester, Alana T. Brennan, Alana T. Brennan, Alana T. Brennan, Masauso M. Phiri, Michael J. Vinikoor, Michael J. Vinikoor, Sepiso K. Masenga, Muktar H. Aliyu, Muktar H. Aliyu, Muktar H. Aliyu   +15 more
doaj   +1 more source