Results 41 to 50 of about 104,728 (194)

Factors associated with chronic calcineurin inhibitor nephrotoxicity in children with minimal-change disease

Renal Failure
Background Calcineurin inhibitors (CNIs), such as cyclosporine (CsA) and tacrolimus (TAC), are commonly used to treat children with complicated minimal change nephrotic syndrome.
Bei Jin, Ziji Lu, Cheng Cheng, Yuxin Pei, Lizhi Chen, Zhihui Yue, Aihua Lin, Shicong Yang, Ying Mo, Xiaoyun Jiang   +9 more
doaj   +1 more source

Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1–PGC-1α pathway activation

Ecotoxicology and Environmental Safety, 2022
Melatonin is an indoleamine produced in the pineal gland and has many physiological roles. There is increasing evidence that melatonin ameliorates cadmium (Cd)-induced nephrotoxicity.
Wenxuan Dong, Lianqi Yan, Yun Tan, Shufang Chen, Kanglei Zhang, Zhonggui Gong, Wenjing Liu, Hui Zou, Ruilong Song, Jiaqiao Zhu, Gang Liu, Zongping Liu   +11 more
doaj   +1 more source

Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection [PDF]

, 2017
Introduction: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam ...
Helps, Alieen, Irvine, Sharon C., Jones, Brian L., Ritchie, Neil D., Robb, Fiona, Seaton, R. Andrew   +5 more
core   +1 more source

Urine kidney injury molecule-1 predicts subclinical kidney disease among persons living with HIV initiating tenofovir disoproxil fumarate-based ART in Zambia

Frontiers in Nephrology
IntroductionAntiretroviral therapy (ART) increases the life expectancy of persons living with HIV (PLWH), but not without potentially serious adverse effects.
Freeman W. Chabala, Edward D. Siew, Edward D. Siew, Edward D. Siew, C. William Wester, C. William Wester, Alana T. Brennan, Alana T. Brennan, Alana T. Brennan, Masauso M. Phiri, Michael J. Vinikoor, Michael J. Vinikoor, Sepiso K. Masenga, Muktar H. Aliyu, Muktar H. Aliyu, Muktar H. Aliyu   +15 more
doaj   +1 more source

Association of high intra-patient variability in tacrolimus exposure with calcineurin inhibitor nephrotoxicity in kidney transplantation

Scientific Reports, 2023
Tacrolimus intra-patient variability (IPV) is a novel predictive marker for long-term kidney transplantation outcomes. We examined the association between IPV and calcineurin inhibitor (CNI) nephrotoxicity and the impact of pharmacogenes on CNI ...
Hyokee Kim, Ahram Han, Sanghyun Ahn, Seung-Kee Min, Jongwon Ha, Sangil Min   +5 more
doaj   +1 more source

Nephroprotective Effects of Alhagi camelorum against Cisplatin-Induced Nephrotoxicity in Albino Wistar Rats

Molecules, 2022
Alhagi camelorum (AC) is an old plant with a significant therapeutic value throughout Africa, Asia, and Latin America. The overuse of cisplatin (Cis > 50 mg/m2) is associated with observed nephrotoxicity, ototoxicity, gastrotoxicity, myelosuppression ...
Muhammad Omer Iqbal, Muhammad Masood Ahmed, Shafia Arshad, Usman Javaid, Imran Ahmad Khan, Majid Manzoor, Shumaila Andleeb, Romana Riaz, Shaukat Hussain Munawar, Zahid Manzoor, Asma Mumtaz   +10 more
doaj   +1 more source

Chronic Kidney Disease of Unknown aetiology (CKDu) and multiple-ion interactions in drinking water

, 2017
Recent experimental work on the nephrotoxicity of contaminants in drinking water using laboratory mice, motivated by the need to understand the origin of chronic kidney disease of unknown aetiology is examined within our understanding of the hydration of
Dharma-wardana, M. W. C.
core   +1 more source

Severe bloodstream infection due to KPC-producer e coli in a renal transplant recipient treated with the double-carbapenem regimen and analysis of in vitro synergy testing a case report [PDF]

, 2016
Transplant recipients are at high risk of infections caused by multidrug resistant microorganisms. Due to the limited thera- peutic options, innovative antimicrobial combinations against carbape- nem-resistant Enterobacteriaceae causing severe infections
CIPOLLA, ALESSIA, D'ABRAMO, ALESSANDRA, DE ANGELIS, Massimiliano, Favaro, Marco, Ferretti, Giancarlo, GIZZI, FRANCESCA, IANNETTA, MARCO, MASCELLINO, Maria Teresa, MASTROIANNI, Claudio Maria, OLIVA, ALESSANDRA, RUSSO, Gianluca, VULLO, Vincenzo   +11 more
core   +1 more source

Comparison of preventive effects of combined furosemide and mannitol versus single diuretics, furosemide or mannitol, on cisplatin-induced nephrotoxicity

Scientific Reports
Cisplatin (CDDP)-induced nephrotoxicity is a common dose-limiting toxicity, and diuretics are often administered to prevent nephrotoxicity. However, the efficacy and optimal administration of diuretics in preventing CDDP-induced nephrotoxicity remain to ...
Ayaka Takagi, Takanori Miyoshi, Toshinobu Hayashi, Hinako Koizumi, Kyouichi Tsumagari, Chiaki Yokota, Takafumi Nakano, Koichi Matsuo, Takashi Egawa   +8 more
doaj   +1 more source

Acute kidney injury in critically ill cancer patients : an update [PDF]

, 2016
Patients with cancer represent a growing group among actual ICU admissions (up to 20 %). Due to their increased susceptibility to infectious and noninfectious complications related to the underlying cancer itself or its treatment, these patients ...
Benoit, Dominique, Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond   +3 more
core   +2 more sources