Results 81 to 90 of about 163,265 (345)

Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors [PDF]

, 2021
Eryk Latoch, Katarzyna Konończuk, Katarzyna Taranta‐Janusz, Katarzyna Muszyńska‐Rosłan, Magdalena Sawicka, Anna Wasilewska, Maryna Krawczuk‐Rybak   +6 more
openalex   +1 more source

Affinity‐Based Protein Profiling Revealed that HIGD1A is a Direct Target Protein of Aristolochic Acids

Advanced Science, EarlyView.
Using an affinity‐based probe, this study reveals that aristolochic acid directly binds to HIGD1A with high affinity in the kidney. This binding disrupts the HIGD1A‐TFAM interaction, which in turn triggers TFAM degradation, cytosolic mitochondrial DNA release, and the activation of inflammatory pathways. Abstract Exposure to aristolochic acids (AA) via
Yin Gong, Shanshan Zhang, Anying Wei, Xiang Ji, Xiaodan Chong, Jinfeng Cen, Xuan Zhao, Zimeng Luo, Zhipeng Pei, Guanchao Mao, Xinkang Zhang, Mingxue Sun, Zhiguo Sun, Zifei Yin, Zhengrong Zou, Wen‐Qi Meng   +15 more
wiley   +1 more source

Diagnostic and prognostic performance of urinary neutrophil gelatinase‐associated lipocalin in patients with cirrhosis and acute kidney injury

Hepatology, EarlyView., 2022
Diagnostic and prognostic ability of urinary NGAL in patients with cirrhosis and AKI. Abstract Background and Aims Acute kidney injury (AKI) commonly occurs in patients with decompensated cirrhosis. Urinary neutrophil gelatinase–associated lipocalin (uNGAL) could help discriminate between different etiologies of AKI.
Carmine Gambino, Salvatore Piano, Matteo Stenico, Marta Tonon, Alessandra Brocca, Valeria Calvino, Simone Incicco, Nicola Zeni, Roberta Gagliardi, Chiara Cosma, Martina Zaninotto, Patrizia Burra, Umberto Cillo, Daniela Basso, Paolo Angeli   +14 more
wiley   +1 more source

Vancomycin dosing design method considering risk factors for nephrotoxicity

Journal of Pharmaceutical Health Care and Sciences
Background Vancomycin (VCM) induces nephrotoxicity in a dose-dependent manner, and patients with risk factors for nephrotoxicity have been reported to develop nephrotoxicity even within the effective concentration range.
Yoshihiko Matsuki, Yutaro Kozima, Megumi Yanagi, Ken-ichi Sako, Tamaki Watanabe, Nobuhiro Yasuno, Shigekazu Watanabe   +6 more
doaj   +1 more source

Can Spesific Biomarkers Be Used to Enlighten the Major Mechanisms of Acute High Dose Diclofenac Sodium-Related Nephrotoxicity?

Eurasian Journal of Emergency Medicine, 2022
Aim:The aim of this study was to examine the basic mechanisms that play a role in the acute nephrotoxicity caused by diclofenac sodium.Materials and Methods:Only water was given to the control group; however, the diclofenac sodium group was group ...
Sinem Doğruyol, İlker Akbaş, Abdullah Osman Koçak, Serpil Aygörmez, Habip Emrah Leylek, Sultan Tuna Akgöl Gür, Özge Ertener   +6 more
doaj   +1 more source

Chronic Kidney Disease of Unknown aetiology (CKDu) and multiple-ion interactions in drinking water

, 2017
Recent experimental work on the nephrotoxicity of contaminants in drinking water using laboratory mice, motivated by the need to understand the origin of chronic kidney disease of unknown aetiology is examined within our understanding of the hydration of
Dharma-wardana, M. W. C.
core   +1 more source

"Suboptimal" kidney donors: The experience with tacrolimus-based immunosuppression [PDF]

, 1996
Female, pediatric, and older donors have been associated with inferior graft survival after renal transplantation. We analyzed these three subgroups in 397 patients receiving tacrolimus-based immunosuppression. There were no differences in recipient age,
Alexander, Brenner, Brenner, Darras, Demetris, Gjertson, Gruessner, Hong, Laskow, McCauley, Neugarten, Nghiem, Opelz, Ploeg, Randhawa, Shapiro, Shapiro, Shapiro, Shapiro, Smith, Starzl, Starzl, Thorogood, Vivas   +23 more
core   +1 more source

Reprogramming the Myocardial Infarction Conductive Microenvironment with Superconductive Ionic Patch for Cardiac Function Repair

Advanced Science, EarlyView.
A super‐conductive ionic patch reprograms the post‐infarction microenvironment by enabling stable ionic migration and electrical signal transmission within damaged myocardium. The patch rapidly adheres to cardiac tissue, enhances conduction velocity, suppresses excitation‐contraction decoupling, and promotes structural and functional cardiac repair in ...
Changyong Wang, Zhuang Zhang, Qi Yin, Changgeng Xu, Linlin Liang, Siwei Li, Yuwei Zhao, Chunlan Wang, Jin Zhou   +8 more
wiley   +1 more source

Risk factors for cisplatin-induced nephrotoxicity and potential of magnesium supplementation for renal protection. [PDF]

PLoS ONE, 2014
Nephrotoxicity remains a problem for patients who receive cisplatin chemotherapy. We retrospectively evaluated potential risk factors for cisplatin-induced nephrotoxicity as well as the potential impact of intravenous magnesium supplementation on such ...
Yasuhiro Kidera, Hisato Kawakami, Tsutomu Sakiyama, Kunio Okamoto, Kaoru Tanaka, Masayuki Takeda, Hiroyasu Kaneda, Shin-ichi Nishina, Junji Tsurutani, Kimiko Fujiwara, Morihiro Nomura, Yuzuru Yamazoe, Yasutaka Chiba, Shozo Nishida, Takao Tamura, Kazuhiko Nakagawa   +15 more
doaj   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source