Results 141 to 150 of about 14,163 (275)

Pulmonary artery pressure trajectories in heart failure patients treated with GLP‐1 receptor agonists

ESC Heart Failure, EarlyView.
Abstract Aims Data support favourable haemodynamic benefits of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) on improving cardiac structural abnormalities and function in patients with heart failure (HF). However, the direct haemodynamic effects of GLP‐1 RAs remain inadequately characterized.
Haoran Jiang, Phuuwadith Wattanachayakul, Veraprapas Kittipibul, Erika Nicolsen, Todd McVeigh, Oksana Kamneva, Marat Fudim   +6 more
wiley   +1 more source

Risk related to pre–diabetes mellitus and diabetes mellitus in heart failure with reduced ejection fraction: insights from prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial [PDF]

, 2016
Background—The prevalence of pre–diabetes mellitus and its consequences in patients with heart failure and reduced ejection fraction are not known.
Cardoso, José Silva, Desai, Akshay S., Jhund, Pardeep S., Kristensen, Søren L., Lefkowitz, Martin P., Martinez, Felipe, McMurray, John J.V., Merkely, Bela, Packer, Milton, Preiss, David, Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Solomon, Scott D., Squire, Iain, Starling, Randall C., Swedberg, Karl, Zile, Michael R.   +17 more
core   +1 more source

Lower NT‐proBNP plasma concentrations in Pacific peoples with heart failure

ESC Heart Failure, EarlyView.
NT‐proBNP plasma concentrations were measured in participants of two NZ HF cohorts and were significantly lower in Pacific peoples and Māori compared with NZ Europeans. After accounting for age, sex, BMI, eGFR, LVEF and presence of AF, NT‐proBNP plasma concentrations remained significantly lower for Pacific peoples, but not for Māori.
Andree G. Pearson, John F. Pearson, Lynley K. Lewis, Allamanda Fa'atoese, Katrina K. Poppe, Chris Pemberton, Gerry Devlin, Mayanna Lund, A. Mark Richards, Richard Troughton, Robert N. Doughty   +10 more
wiley   +1 more source

Rationale and study design of the Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study. [PDF]

, 2014
Hypertension in elderly people is characterised by elevated systolic blood pressure (SBP) and increased pulse pressure (PP), which indicate large artery ageing and stiffness.
Brunel, P, Cardenas, P, Cockcroft, JR, Hester, A, Kario, K, Williams, B, Zappe, DH, Zhang, J   +7 more
core   +1 more source

Do differences among heart failure patients affect their access to treatment?

ESC Heart Failure, EarlyView.
Halit Emre Yalvaç, Bulent Gorenek
wiley   +1 more source

Real‐world use of guideline‐directed therapy for heart failure: Insights from the Danish Heart Failure Registry

ESC Heart Failure, EarlyView.
Our study examined the real‐world implementation of guideline‐directed medical therapy (GDMT) and its association with mortality and hospitalization in 46 816 patients with heart failure with reduced ejection fraction (HFrEF) from the Danish Heart Failure Registry (2008–2022).
Inge Schjødt, Jan B. Valentin, Søren P. Johnsen, Rikke E. Mols, Kenneth Egstrup, Brian B. Løgstrup   +5 more
wiley   +1 more source

Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling

Neuron, 2023
Eunhee Kim, Hyeonwoo Kim, Mark P. Jedrychowski, Grisilda Bakiasi, Joseph Park, Jane Kruskop, Younjung Choi, Sang Su Kwak, L. Quinti, Doo Yeon Kim, C. Wrann, B. Spiegelman, Rudolph E. Tanzi, Se Hoon Choi   +13 more
semanticscholar   +1 more source

Placental Syncytiotrophoblast-Derived Extracellular Vesicles Carry Active NEP (Neprilysin) and Are Increased in Preeclampsia

HYPERTENSION, 2019
NEP (neprilysin) is a widely expressed membrane-bound metalloprotease, which binds and cleaves a variety of peptides including vasodilators, natriuretics, and diuretics.
M. Gill, Carolina Motta-Mejia, N. Kandzija, W. Cooke, Wei Zhang, A. Cerdeira, C. Bastie, C. Redman, M. Vatish   +8 more
semanticscholar   +1 more source

Association between NT‐proBNP changes and clinical outcomes in paediatric patients with heart failure: Insights from PANORAMA‐HF and PARADIGM‐HF

ESC Heart Failure, EarlyView.
This post hoc analysis of the PANORAMA‐HF paediatric heart failure trial evaluates the correlation of baseline and clinical changes in NT‐proBNP and clinical outcomes in children with heart failure due to left ventricular systolic dysfunction. This is the first prospective, randomized large‐scale study to demonstrate that changes in NT‐proBNP levels ...
Robert Shaddy, Jianjian Gong, Tania Garito, Susan Solar‐Yohay, Sijia Zhang, Margaret F. Prescott, Damien Bonnet, Paul F. Kantor, Michael Burch, Chad Mao, Antoinette Cilliers, Charles Canter, Yuk Law, Giorgia Grutter, Jou Kou Wang, Aamir Jeewa, Joseph Rossano, on behalf of PANORAMA‐HF investigators   +17 more
wiley   +1 more source

Not so Dangerous After All? Venom Composition and Potency of the Pholcid (Daddy Long-Leg) Spider Physocyclus mexicanus

Frontiers in Ecology and Evolution, 2019
Pholcid spiders (Araneae: Pholcidae), officially “cellar spiders” but popularly known as “daddy long-legs,” are renown for the potential of deadly toxic venom, even though venom composition and potency has never formally been studied.
Pamela A. Zobel-Thropp, Jennifer Mullins, Charles Kristensen, Brent A. Kronmiller, Cynthia L. David, Linda A. Breci, Greta J. Binford   +6 more
doaj   +1 more source