Successful use of axonal transport for drug delivery by synthetic molecular vehicles [PDF]
, 2008 We report the use of axonal transport to achieve intraneural drug delivery. We constructed a novel tripartite complex of an axonal transport facilitator conjugated to a linker molecule bearing up to a hundred reversibly attached drug molecules.
Aaron G. Filler +12 more
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Erectile dysfunction - an update of current practice and future strategies [PDF]
, 2013 Erectile dysfunction (ED) is defined as the inability to achieve and maintain a penile erection adequate for satisfactory sexual intercourse.1 Up to 150 million men worldwide suffer from ED and this figure is likely to double by the year 2025.2 A number
Kalsi, J, Muneer, A
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4‐Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury
EMBO Molecular Medicine, 2016 Traumatic peripheral nerve damage is a major medical problem without effective treatment options. In repurposing studies on 4‐aminopyridine (4‐AP), a potassium channel blocker that provides symptomatic relief in some chronic neurological afflictions, we ...
Kuang‐Ching Tseng +6 more
doaj +1 more source
The 6-minute walk test and other endpoints in Duchenne muscular dystrophy: longitudinal natural history observations over 48 weeks from a multicenter study. [PDF]
, 2013 IntroductionDuchenne muscular dystrophy (DMD) subjects ≥5 years with nonsense mutations were followed for 48 weeks in a multicenter, randomized, double-blind, placebo-controlled trial of ataluren.
Abresch, R Ted +12 more
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Acta Medica, 2005 1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6)
Kamil Kuča +4 more
doaj +1 more source
Scientific Reports, 2016 Organophosphates are powerful inhibitors of acetylcholinesterase, which is critical to nerve function. Despite continuous research for detecting the highly toxic organophosphates, a new and improved methodology is still needed.
Oh Seok Kwon +8 more
semanticscholar +1 more source
Female rats are less susceptible during puberty to the lethal effects of percutaneous exposure to VX
Toxicology Reports, 2016 Nerve agents with low volatility such as VX are primarily absorbed through the skin when released during combat or a terrorist attack. The barrier function of the stratum corneum may be compromised during certain stages of development, allowing VX to ...
Linnzi K.M. Wright +3 more
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How Do We Get Rid of These Things? Dismantling Excess Weapons While Protecting the Environment [PDF]
, 1995 The startling successes of contemporary international arms control negotiations call to mind the old aphorism that one should be careful about what one wishes for, because the wish just might come true.
Koplow, David A
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Conditioned place preference reveals ongoing pain in calves 3 weeks after disbudding. [PDF]
, 2020 Hot-iron disbudding, a routine procedure that prevents horn bud growth through cauterization, is painful for calves. The resulting burns remain sensitive to touch for weeks, but it is unknown whether calves experience ongoing, non-evoked pain.
Adcock, Sarah JJ, Tucker, Cassandra B
core
Concomitant changes in formaldehyde‐induced fluorescence of dopamine interneurones and in slow inhibitory post‐synaptic potentials of the rabbit superior cervical ganglion, induced by stimulation of the preganglionic nerve or by a muscarinic agent [PDF]
, 1974 Benjamin Libet, Ch. Owman
openalex +1 more source