Results 41 to 50 of about 205,418 (209)

Development of acetylcholinesterase immobilized CMD (Carboxymethyldextran) chip-based sensor for the detection of nerve agent simulant parathion

Cumhuriyet Science Journal, 2020
In this study, a carboxymethyldextran chip based sensor system is developed that selectively recognizes and binds nerve agent molecules used in chemical weapons. Nerve agents fall under the group of organophosphorus compounds and irreversibly inhibit the
Ozan Yağmuroğlu, Sibel Emir Diltemiz
doaj   +1 more source

Analysis of Organophosphorus-Based Nerve Agent Degradation Products by Gas Chromatography-Mass Spectrometry (GC-MS): Current Derivatization Reactions in the Analytical Chemist’s Toolbox

Molecules, 2021
The field of gas chromatography-mass spectrometry (GC-MS) in the analysis of chemical warfare agents (CWAs), specifically those involving the organophosphorus-based nerve agents (OPNAs), is a continually evolving and dynamic area of research.
Carlos A. Valdez, Roald N. Leif
doaj   +1 more source

The prediction of hydrolysis and biodegradation of organophosphorus-based chemical warfare agents (G-series and V-series) using toxicology in silico methods

Ecotoxicology and Environmental Safety
Nerve agents (G- and V-series) are a group of extremely toxic organophosphorus chemical warfare agents that we have had the opportunity to encounter many times on a massive scale (Matsumoto City, Tokyo subway and Gulf War).
Maciej Noga, Agata Michalska, Kamil Jurowski   +2 more
doaj   +1 more source

Smart Sensing of Nerve Agents

ChemPlusChem
AbstractThe recent international scenario highlights the importance to protect human health and environmental quality from toxic compounds. In this context, organophosphorous (OP) Nerve Agents (NAs) have received particular attention, due to their use in terrorist attacks.
Puglisi, Roberta, Santonocito, Rossella, Pappalardo, Andrea, Trusso Sfrazzetto, Giuseppe   +3 more
openaire   +3 more sources

Fluorometric and Colorimetric Biosensors for the Assay of Cholinesterase Inhibitors

Sensors
Cholinesterases, specifically acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), play critical roles in neurotransmission and are key targets for inhibitors with therapeutic and toxicological significance.
Miroslav Pohanka
doaj   +1 more source

Impact of antidote quantity, timing and prehospital strategies in nerve agent mass casualty events: a simulation study

Frontiers in Public Health
IntroductionMass casualty incidents (MCIs) involving nerve agents pose major challenges for emergency medical response due to rapid symptom onset, hazardous environments, and operational uncertainties.
Ruben De Rouck, Mehdi Benhassine, Michel Debacker, Filip Van Utterbeeck, Jan Vaes, Isabell Meskens, Ives Hubloue   +6 more
doaj   +1 more source

In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase

Molecules, 2020
The implementation of the Chemical Weapons Convention (CWC) in 1997 was a milestone in the prohibition of chemical warfare agents (CWA). Yet, the repeated use of CWA underlines the ongoing threat to the population.
Franz Worek, Horst Thiermann, Marianne Koller, Timo Wille   +3 more
doaj   +1 more source

Structure–efficiency relationships of cyclodextrin scavengers in the hydrolytic degradation of organophosphorus compounds

Beilstein Journal of Organic Chemistry, 2017
New derivatives of cyclodextrins were prepared in order to determine the relative importance of the structural key elements involved in the degradation of organophosphorus nerve agents.
Sophie Letort, Michaël Bosco, Benedetta Cornelio, Frédérique Brégier, Sébastien Daulon, Géraldine Gouhier, François Estour   +6 more
doaj   +1 more source

From energy-rich phosphate compounds to warfare agents: A review on the chemistry of organic phosphate compounds

Orbital: The Electronic Journal of Chemistry, 2008
The chemistry of the phosphorus-oxygen bond is widely used in biological systems in many processes, such as energy transduction and the storage, transmission and expression of genetic information, which are essential to living beings in relation to a ...
Luciano Albino Giusti, Vanderlei Gageiro Machado   +1 more
doaj   +1 more source

Hydrophobic Fluorinated Porous Organic Frameworks for Enhanced Adsorption of Nerve Agents

Applied Sciences, 2020
Humidity in the air can significantly limit the adsorption capacity of porous materials used for the removal of chemical warfare agents (CWAs). Therefore, in this work, we prepared a porous organic material (C-1) and its fluoride derivative (C-1-F) via a
Shuyuan Zhou, Weimin Kong, Kunpeng Wang, Hao Han, Derui Yang, Yue Zhao, Hong Zhou, Qinghao Meng, Ye Yuan   +8 more
doaj   +1 more source