Results 1 to 10 of about 44,718 (204)

Retinal ganglion cell survival and axon regeneration in Wld^S transgenic rats after optic nerve crush and lens injury [PDF]

BMC Neuroscience, 2012
Background We have previously shown that the slow Wallerian degeneration mutation, whilst delaying axonal degeneration after optic nerve crush, does not protect retinal ganglion cell (RGC) bodies in adult rats.
Lorber Barbara, Tassoni Alessia, Bull Natalie D, Moschos Marilita M, Martin Keith R   +4 more
doaj   +5 more sources

Visualizing peripheral nerve regeneration by whole mount staining. [PDF]

PLoS ONE, 2015
Peripheral nerve trauma triggers a well characterised sequence of events both proximal and distal to the site of injury. Axons distal to the injury degenerate, Schwann cells convert to a repair supportive phenotype and macrophages enter the nerve to ...
Xin-peng Dun, David B Parkinson
doaj   +4 more sources

Application of Human Epineural Patch (hEP) as a Novel Strategy for Nerve Protection and Enhancement of Regeneration After Nerve Crush Injury [PDF]

Biomedicines
Background: Numerous experimental studies aim to improve outcomes of peripheral nerve repair following trauma. This study evaluates the efficacy of the human epineural patch (hEP) compared to the human amniotic membrane (hAM) in promoting nerve ...
Katarzyna Kozlowska, Weronika Radecka, Sonia Brodowska, Lucile Chambily, Dominika Kuc, Amber Lopez, Maria Siemionow   +6 more
doaj   +2 more sources

Biomechanical evaluation of peripheral nerves after crush injuries [PDF]

Heliyon, 2019
Background: Crush injury of nerves is a common condition but the biomechanical integrity of the human peripheral nerve after crushing is unknown. This study aims to investigate the impact of crush injury on human digital nerves based on different ...
Yoke-Rung Wong, Xin Pang, Zeus Yiwei Lim, Hejun Du, Shian-Chao Tay, Duncan Angus McGrouther   +5 more
doaj   +4 more sources

Protective vs. Therapeutic Effects of Mitochondria-Targeted Antioxidant MitoTEMPO on Rat Sciatic Nerve Crush Injury: A Comprehensive Electrophysiological Analysis [PDF]

Biomedicines, 2023
Protective vs. Therapeutic Effects of Mitochondria-Targeted Antioxidant MitoTEMPO on Rat Sciatic Nerve Crush Injury: A Comprehensive Electrophysiological Analysis.
Murat Cenk Celen, Ahmet Akkoca, Seckin Tuncer, Nizamettin Dalkilic, Barkin Ilhan   +4 more
doaj   +2 more sources

Adenosine A2A receptor activation is necessary to gate the TrkB-dependent intramuscular nerve sprouting during muscle reinnervation after a nerve crush [PDF]

Heliyon
Compelling evidence has demonstrated that rehabilitation through physical exercise, a non-invasive and non-surgical intervention, enhances muscle reinnervation and motor recovery after peripheral nerve injury (PNI) by increasing muscle-derived brain ...
Michael Di Palma, Davide Lattanzi, Patrizia Ambrogini, Stefano Sartini   +3 more
doaj   +2 more sources

Neuroregeneration of injured peripheral nerve by fraction B of catfish epidermal secretions through the reversal of the apoptotic pathway and DNA damage

Frontiers in Pharmacology, 2023
Introduction: Crush injuries occur from acute traumatic nerve compression resulting in different degrees of neural damage leading to permanent functional deficits.
Taiba A. Al-Arbeed, Waleed M. Renno, Jassim M. Al-Hassan   +2 more
doaj   +1 more source

Targeting anti-inflammatory treatment can ameliorate injury-induced neuropathic pain. [PDF]

PLoS ONE, 2013
Tumor necrosis factor-α plays important roles in immune system development, immune response regulation, and T-cell-mediated tissue injury. The present study assessed the net value of anti-tumor necrosis factor-α treatment in terms of functional recovery ...
Katsuyuki Iwatsuki, Tetsuya Arai, Hideyuki Ota, Shuichi Kato, Tadahiro Natsume, Shigeru Kurimoto, Michiro Yamamoto, Hitoshi Hirata   +7 more
doaj   +1 more source

Evaluation methods of a rat sciatic nerve crush injury model

Journal of Integrative Neuroscience, 2022
Background: The rat sciatic nerve crush injury model is one of the most commonly used models to research peripheral nerve injury (PNI), however, the evaluation of the model preparation lacks exact standards.
Yun An, Hui-Xin Yan, Jiang-Na Zhao, Xu-Ming Yang, Jun-Tao Yan   +4 more
doaj   +1 more source

Lack of correlation between spinal microgliosis and long-term development of tactile hypersensitivity in two different sciatic nerve crush injury

Molecular Pain, 2021
Microglia activation following peripheral nerve injury has been shown to contribute to central sensitization of the spinal cord for the development of neuropathic pain.
Hyoung Woo Kim, Chan Hee Won, Seog Bae Oh   +2 more
doaj   +1 more source