Results 181 to 190 of about 1,249,880 (378)

Nb2CBr2 MXene Monolayer as a Novel Material: A First Principle Study

open access: yesAdvanced Theory and Simulations, EarlyView.
Illustration of the monolayer cell, cell replicated in directions a and b, graph of optical absorption and thermodynamic potentials as a function of temperature. Abstract Niobium‐based MXenes show promising properties and applications, but have not yet been sufficiently investigated, especially with halogen surface terminations. This study investigates
Leonardo S. Barbosa   +4 more
wiley   +1 more source

An induced pluripotent stem cell-based model identifies molecular targets of vincristine neurotoxicity

open access: yesDisease Models & Mechanisms, 2022
Neng-Wei Tsai   +6 more
doaj   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

open access: yesAdvanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu   +15 more
wiley   +1 more source

Investigation of the Hydrogen Sulfide Signaling Pathway in Schwann Cells during Peripheral Nerve Degeneration: Multi-Omics Approaches. [PDF]

open access: yesAntioxidants (Basel), 2022
Chun YL   +15 more
europepmc   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

open access: yesAdvanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva   +28 more
wiley   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

open access: yesAdvanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang   +16 more
wiley   +1 more source

Axonal Protection by Netarsudil, a ROCK Inhibitor, Is Linked to an AMPK-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration. [PDF]

open access: yesInvest Ophthalmol Vis Sci, 2022
Kitaoka Y   +7 more
europepmc   +1 more source

The distribution of toxic metals in the human retina and optic nerve head: Implications for age-related macular degeneration

open access: gold, 2020
Roger Pamphlett   +5 more
openalex   +2 more sources

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