Results 161 to 170 of about 175,050 (352)

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

open access: yesAdvanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen   +14 more
wiley   +1 more source

3-Dimensional Immunostaining and Automated Deep-Learning Based Analysis of Nerve Degeneration. [PDF]

open access: yesInt J Mol Sci, 2022
Drake SS   +9 more
europepmc   +1 more source

Transneuronal degeneration due to peripheral nerve injury in the rats

open access: yes, 2001
When an axon is severed, degenerative changes occur in the injured neuron as weB as in those with which it has synaptic connections through transneuronal degeneration. Transneuronal degeneration includes all atrophic or degenerative changes that occur in
김명희, 곽현호, 박형우
core  

Degeneration of auditory nerve fibers in guinea pigs with severe sensorineural hearing loss

open access: yes, 2017
Damage to and loss of the organ of Corti leads to secondary degeneration of the spiral ganglion cell (SGC) somata of the auditory nerve. Extensively examined in animal models, this degeneration process of SGC somata following deafening is well known ...
Kroon, Steven   +5 more
core   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

open access: yesAdvanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong   +8 more
wiley   +1 more source

Toll-Like Receptor 3 Contributes to Wallerian Degeneration after Peripheral Nerve Injury

open access: yes, 2017
Objective: It is well known that Schwann cells play an important role in Wallerian degeneration after peripheral nerve injury. Previously, we reported that toll-like receptor 3 (TLR3) is expressed on Schwann cells, implicating its role in Schwann cell ...
Min, Hyunjung   +5 more
core   +1 more source

Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons

open access: green, 2006
Jill M. Weimer   +7 more
openalex   +2 more sources

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

open access: yesAdvanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu   +10 more
wiley   +1 more source

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