Results 151 to 160 of about 167,091 (260)

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

TLR4 deletion reduces small fiber sensory abnormalities and nerve degeneration in diabetic male mice. [PDF]

Neuroscience
Crowards S, Ryals J, Heslop L, Hauser W, Totta-Griese G, Madden T, Wright DE.   +6 more
europepmc   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source

The Effects of Disease-Modifying Therapies on Optic Nerve Degeneration in Multiple Sclerosis. [PDF]

Eur J Neurol
Zhang X, Song S, Chen B, Leocani L, Zhao X, Zhong Y, Pisa M, Sharma SM.   +7 more
europepmc   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

CD4+CD25- T-Cell-Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice. [PDF]

Invest Ophthalmol Vis Sci
Lin Y, Yang L, Li Y, Dou S, Zhang Z, Zhou Q.   +5 more
europepmc   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Obesity-induced Nerve Degeneration and Inflammation: Therapeutic Effects of β-Hydroxybutyrate and Melatonin on Pyroptosis, ER Stress, and Hippocampal Dysfunction in High-Fat Diet-Fed Rats. [PDF]

Inflammation
Zeynali Z, Maleki MH, Doagoo A, Khabaz MJR, Omidi F, Dehghanian A, Vakili O, Shafiee SM.   +7 more
europepmc   +1 more source

Very Early Involvement of Innate Immunity in Peripheral Nerve Degeneration in SOD1-G93A Mice. [PDF]

Front Immunol, 2020
Angelini DF, De Angelis F, Vacca V, Piras E, Parisi C, Nutini M, Spalloni A, Pagano F, Longone P, Battistini L, Pavone F, Marinelli S.   +11 more
europepmc   +1 more source

Influence of galantamine on peripheral nerve degeneration after experimental compression injury of the rat sciatic nerve. [PDF]

Ulus Travma Acil Cerrahi Derg, 2022
Alagöz F, Şahinoğlu M, Billur D, Aydın S, Akdağ R, Karakoyun DO, Daglıoğlu E.   +6 more
europepmc   +1 more source