Results 181 to 190 of about 175,050 (352)

An induced pluripotent stem cell-based model identifies molecular targets of vincristine neurotoxicity

Disease Models & Mechanisms, 2022
Neng-Wei Tsai, Cheng-Chen Lin, Ti-Yen Yeh, Yu-An Chiu, Hsin-Hui Chiu, Hsiang-Po Huang, Sung-Tsang Hsieh   +6 more
doaj   +1 more source

Investigation of the Hydrogen Sulfide Signaling Pathway in Schwann Cells during Peripheral Nerve Degeneration: Multi-Omics Approaches. [PDF]

Antioxidants (Basel), 2022
Chun YL, Eom WJ, Lee JH, Nguyen TNC, Park KH, Chung HJ, Seo H, Huh Y, Kim SH, Yeo SG, Park W, Bang G, Kim JY, Kim MS, Jeong NY, Jung J.   +15 more
europepmc   +1 more source

Temperature Coefficient of Nerve Degeneration [PDF]

Proceedings of the National Academy of Sciences, 1934
openaire   +2 more sources

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Highly Bioadaptable Hybrid Conduits with Spatially Bidirectional Structure for Precision Nerve Fiber Regeneration via Gene Therapy

Advanced Science
Peripheral nerve deficits give rise to motor and sensory impairments within the limb. The clinical restoration of extensive segmental nerve defects through autologous nerve transplantation often encounters challenges such as axonal mismatch and ...
Renliang Zhao, Xiangtian Deng, Jizhao Dong, Chen Liang, Xiaozhong Yang, Yunfeng Tang, Juan Du, Zilu Ge, Dong Wang, Yifan Shen, Lianghua Jiang, Wei Lin, Tonghe Zhu, Guanglin Wang   +13 more
doaj   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Expression of neuropeptides – galanin and Reg2 - in subcategories of nociceptors after nerve injury

, 2010
PhDNeuropeptides show dynamic changes in expression after nerve injury, and have been implicated in chronic pain states. I sought to compare expression of two peptides which are upregulated after nerve injury, galanin and Reg2, and to determine the ...
Burrows, Karen Lynne
core  

Pattern of Spine Degenerative Disease Among Patients Referred for Lumbar Magnetic Resonance Imaging at Muhimbili National Hospital, Dar es salaam, Tanzania March-September-2010. [PDF]

, 2011
Background Degenerative disease of the lumbar spine refers to a syndrome in which an intervertebral disk with adjacent spine structures are compromised. This causes low back and lower extremity pain.
Jacob, Mboka
core  

Axonal Protection by Netarsudil, a ROCK Inhibitor, Is Linked to an AMPK-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration. [PDF]

Invest Ophthalmol Vis Sci, 2022
Kitaoka Y, Sase K, Tsukahara C, Fujita N, Arizono I, Kogo J, Tokuda N, Takagi H.   +7 more
europepmc   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source