Results 231 to 240 of about 1,223,403 (400)

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

The Degree of Degeneration in the Facial Nerve Nuclear Cells after Facial Trunk Injuries

, 1979
Tsuguo Kokan
openalex   +2 more sources

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source

Abstracts of the foundation for life sciences symposium on muscle, nerve, and brain degeneration Sydney, NSW, Australia February 14–16, 1979

, 1979

openalex   +2 more sources

Capsaicin induces degeneration of cutaneous autonomic nerve fibers [PDF]

, 2010
Christopher H. Gibbons, Ningshan Wang, Roy Freeman   +2 more
openalex   +1 more source

Magnetic‐Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models

Advanced Science, EarlyView.
Magnetic field‐guided MNP@ATR‐ASO nanocomplexes facilitate the targeted delivery of ASOs to ganglion cells or photoreceptors within retinal explants, thereby enhancing the efficacy of ASOs in correcting pre‐mRNA splicing abnormalities. Furthermore, the nanocomplexes improve ASO penetration and delivery in human retinal and inner ear organoid models ...
Xiuhong Ye, Sihui Chen, Wei Xiong, Fan Wang, Hon Fai Chan, Haocheng Lai, Xiangyu Guo, Tingting Yang, Shuhao Shen, Hang Chen, Wenxuan Wang, Guei‐Sheung Liu, Yonglong Guo, Jiansu Chen   +13 more
wiley   +1 more source

Influence of galantamine on peripheral nerve degeneration after experimental compression injury of the rat sciatic nerve. [PDF]

Ulus Travma Acil Cerrahi Derg, 2022
Alagöz F, Şahinoğlu M, Billur D, Aydın S, Akdağ R, Karakoyun DO, Daglıoğlu E.   +6 more
europepmc   +1 more source

Over‐expression of alpha‐synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain [PDF]

, 2010
Heike Siebert, Philipp J. Kahle, M. Kramer, Thomas Isik, Oliver M. Schlüter, Walter Schulz‐Schaeffer, Wolfgang Brück   +6 more
openalex   +1 more source

Manipulation of Oxygen Tension in Damaged Regions via Hypoxia‐Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration

Advanced Science, EarlyView.
A novel interpenetrating network hydrogel microsphere (NSC‐Exos@HIMS) is developed to manipulate oxygen tension in damaged regions and recruit endogenous stem cells. In vitro and in vivo results show that NSC‐Exos@HIMS maintains the hypoxia microenvironment for up to 5 days, which triggers nucleus pulposus cell‐like differentiation and enhanced ECM ...
Xingdie Zhou, Zhendong Lv, Zehao Chen, Yiming Xu, Chao Lin, Li Liu, Hao Chen, Bing Niu, Wenguo Cui, Yuhui Zhang   +9 more
wiley   +1 more source

Older spiny mice (Acomys cahirinus) have delayed and spatially heterogenous ear wound regeneration

Biology Open
Justin A. Varholick, Jazmine Thermolice, Gizelle Godinez, Vanessa Dos Santos, Rishi Kondapaneni, Malcolm Maden   +5 more
doaj   +1 more source