Results 41 to 50 of about 656,722 (293)

Small Fibre Neuropathy in Parkinson’s Disease: Comparison of Skin Biopsies from the More Affected and Less Affected Sides

Journal of Parkinson’s Disease, 2019
We assessed small nerve fibre degeneration and regeneration in more and less affected sides in Parkinson’s disease (PD). Bilateral skin biopsies from 23 PD patients were immunostained for PGP9.5 for Intraepidermal Nerve Fibre Density (IENFD) and GAP-43 ...
Maria Jeziorska, Andrew Atkinson, Lewis Kass-Iliyya, Christopher Kobylecki, David Gosal, Andrew Marshall, Rayaz A. Malik, Monty Silverdale   +7 more
doaj   +1 more source

Selective Fiber Degeneration in the Peripheral Nerve of a Patient With Severe Complex Regional Pain Syndrome

Frontiers in Neuroscience, 2018
Aims: Complex regional pain syndrome (CRPS) is characterized by chronic debilitating pain disproportional to the inciting event and accompanied by motor, sensory, and autonomic disturbances. The pathophysiology of CRPS remains elusive.
Adrien Yvon, Adrien Yvon, Alessandro Faroni, Adam J. Reid, Adam J. Reid, Vivien C. Lees   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Effect of polysaccharide on functional recovery after decompression in a rat model of degenerative cervical myelopathy [PDF]

Asian Spine Journal
Study Design Animal study. Purpose To investigate the effects of Lycium barbarum polysaccharide (LBP) on functional recovery following decompressive surgery in a rat model of cervical spondylotic myelopathy (CSM).
Kang-heng Wang, Guang-Sheng Li, Rong Li, Kwok Fai So, Chung Yin Tai, Yong Hu, Kenny Yat Hong Kwan   +6 more
doaj   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Analysis of the C/EBP family of transcription factors in neuronal repair [PDF]

, 2009
PhDNeurons within the peripheral nervous system (PNS) have a remarkable ability to repair themselves after injury; however, neurons within the central nervous system (CNS) do not spontaneously regenerate.
López de Heredia, Luis
core   +4 more sources

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Radioprotective Effects of Vitis vinifera L. Seed against Radiation-Induced Short-Term Memory Loss in Young Adult Wistar Rats [PDF]

Iranian Journal of Medical Physics
Introduction: Brain radiation therapy often results in short-term memory loss that progresses to cognitive impairment. This issue primarily arises from ionizing radiation generating reactive oxygen species, contributing to chronic oxidative stress that ...
Ayomide Abe, Fatai Balogun, Olugbenga Ayannuga   +2 more
doaj   +1 more source

Clinical feature and sural biopsy study in nitrous oxide-induced peripheral neuropathy.

PLoS ONE, 2022
ObjectiveThe objective was to analyze the clinical characteristics and pathological characteristics of sural biopsy in nitrous oxide (N2O) -induced peripheral neuropathy.MethodsWe recruited 18 patients with N2O abuse-induced neurological disorders and ...
Qian Wang, Xiaohui Duan, Mingrui Dong, Shaojie Sun, Pan Zhang, Fang Liu, Li Wang, Renbin Wang   +7 more
doaj   +1 more source