Results 91 to 100 of about 23,201 (210)

First‐in‐human microelectrode recordings from the vagus nerve during clinical vagus nerve stimulation

Epilepsia Open
Introduction Vagus nerve stimulation (VNS) is an effective treatment for people with drug‐resistant epilepsy. However, its mechanisms of action are poorly understood, including which nerve fibers are activated in humans during VNS in typical clinical ...
Mikaela Patros, David G. S. Farmer, Kegan Moneghetti, Matteo M. Ottaviani, Shobi Sivathamboo, Hugh D. Simpson, Terence J. O'Brien, Vaughan G. Macefield   +7 more
doaj   +1 more source

Pyruvate Kinase M2 Upregulation Is Associated With Guillain–Barré Syndrome Risk and Immune Dysregulation: Insights From Mendelian Randomization and the Experimental Autoimmune Neuritis Model

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Objective This study aimed to investigate the potential involvement of pyruvate kinase M2 (PKM2) in the pathogenesis of Guillain–Barré syndrome (GBS). Methods Mendelian randomization (MR) analysis was used to evaluate the causal association between PKM2 expression and GBS susceptibility, with mediation analysis performed to explore immune cell‐
Shuping Liu, Huiying Lu, Yuge Kang, Zheman Xiao, Qian Min, Yi Dong   +5 more
wiley   +1 more source

Yin Yang 1 Specifically Supports the Development of Olig2 Positive Cerebellar Astrocytes

Glia, Volume 74, Issue 8, August 2026.
Cerebellar Olig2 positive astrocytes are most abundant in the cerebellar nuclei. Cerebellar astrocytes expressing Olig2 have unique gene expression profiles. Yin Yang 1 specifically supports the development of astrocytes expressing Olig2. Deletion of YY1 during development increases numbers of astrocytes expressing Olig2 but hinders their ...
Masoumeh Zarei‐Kheirabadi, Katarzyna M. Tyc, Lauren Dain, Maryam Ashrafi Kheirabadi, Jennifer Hanco, Karli Mockenhaupt, Soha Munir, Adam McQuiston, Sandeep K. Singh, Tomasz Kordula   +9 more
wiley   +1 more source

Keratan Sulfate: An Electroconductive Glycosaminoglycan at the Interface of Sensory Perception and Neural Signaling

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley   +1 more source

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, Volume 183, Issue 16, Page 5120-5147, August 2026.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

The Diagnostic Accuracy of the Second Revision of the European Academy of Neurology/Peripheral Nerve Society Guideline for Diagnosing Chronic Inflammatory Demyelinating Polyradiculoneuropathy

European Journal of Neurology, Volume 33, Issue 8, August 2026.
ABSTRACT Background Diagnosing chronic inflammatory demyelinating polyneuropathy (CIDP) relies on clinical and electrodiagnostic features. In 2021, the European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) revised the CIDP guideline, superseding the 2010 European Federation of Neurological Societies (EFNS)/PNS guideline.
Iris N. van Doorn, Adája E. Baars, Luuk Wieske, Bart C. Jacobs, Krista Kuitwaard, W. Ludo van der Pol, Pieter A. van Doorn, Ivo N. van Schaik, Filip Eftimov, H. Stephan Goedee, Judith Drenthen, Camiel Verhamme   +11 more
wiley   +1 more source

Sudomotor dysfunction in people with type 1 diabetes with and without clinical peripheral neuropathy: A study from Pune, India

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1358-1366, August 2026.
ABSTRACT Background and Aims It is appreciated that current screening tools for diabetic peripheral neuropathy (DPN) often fail to detect early disease. Sudomotor (sweat gland) dysfunction, among the earliest manifestations of DPN, can be measured objectively by the SUDOSCAN® device. We compared SUDOSCAN® with conventional validated screening (Michigan
Rohan Shah, Rishikesh Behere, Aboli Bhalerao, Sanat Phatak, Alma Baptist, Chinmay S. Marathe, Chittaranjan S. Yajnik   +6 more
wiley   +1 more source

The Ionic Currents in the Myelinated Nerve Fiber [PDF]

The Journal of General Physiology, 1965
openaire   +2 more sources

The Impact of Hairs on Local Skin Wetness Perception at the Underarm During Static and Dynamic Applications of Cold‐Wet Stimuli

Journal of Sensory Studies, Volume 41, Issue 4, August 2026.
ABSTRACT Previous research highlights that wetness perception differs between hairy and glabrous skin, yet it remains unclear how hairs affect wetness perception in the same region. This study investigated the role of underarm hair on wetness perception to inform antiperspirant design.
Jade Ward, Joshua Martin, Dave Swaile, Katie Parker, Brooke Cochran, Peter R. Worsley, Davide Filingeri   +6 more
wiley   +1 more source

Physiological mechanisms and therapeutic targets in chronic cough

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract Cough is a vital defensive reflex that safeguards the airways; however, it can become maladaptive and pathological. Chronic cough (>8 weeks in duration) affects up to 10% of the global adult population and is associated with considerable health status impairment. The understanding of cough physiology remains limited.
James C. Brown, Katherine L. Rhatigan, Oliver J. Price, Peter S. P. Cho   +3 more
wiley   +1 more source