Results 51 to 60 of about 113,844 (214)

Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. [PDF]

, 2016
Charcot-Marie-Tooth disease type 2A (CMT2A), the most common axonal form of hereditary sensory motor neuropathy, is caused by mutations of mitofusin-2 (MFN2). Mitofusin-2 is a GTPase required for fusion of mitochondrial outer membranes, repair of damaged
Bannerman, Peter, Burns, Travis, Miers, Laird, Pleasure, David, Xu, Jie   +4 more
core   +10 more sources

APPLICATION OF STEREOLOGICAL METHODS TO STUDY THE WHITE MATTER AND MYELINATED FIBERS THEREIN OF RAT BRAIN

Image Analysis and Stereology, 2011
An efficient and unbiased stereological method was applied to estimate the white matter volume, the total volume, total length and mean diameter of the myelinated fibers in the white matter and the total volume of the myelin sheaths in the white matter ...
Shu Yang, Chen Li, Wei Zhang, Weiwei Wang, Jens R Nyengaard, Yong Tang   +5 more
doaj   +1 more source

Estimation of fiber diameters in the spinal dorsal columns from clinical data [PDF]

, 1998
Lack of human morphometric data regarding the largest nerve fibers in the dorsal columns (DCs) of the spinal cord has lead to the estimation of the diameters of these fibers from clinical data retrieved from patients with a new spinal cord stimulation ...
Boom, Herman B.K., Gybels, Jan M., Holsheimer, Jan, King, Gary W., Nuttin, Bart, Sutter, Paul de, Wesselink, Wilbert A.   +6 more
core   +3 more sources

Transitory traumatic paraplegia: electron microscopy of early alterations in myelinated nerve fibers.

Journal of Neurosurgery, 1972
✓ The white matter of the monkey spinal cord was examined by electron microscopy during the first 4 hours following a contusion sufficient to produce a transitory paraplegia.
G. Dohrmann, F. Wagner, P. Bucy
semanticscholar   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Electrically Evoked Compound Action Potentials in Spinal Cord Stimulation: Implications for Preclinical Research Models

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives The study aimed to assess the feasibility of recording electrically evoked compound action potentials (ECAPs) from the rat spinal cord. To achieve this, we characterized electrophysiological responses of dorsal column (DC) axons from electrical stimulation and quantified the relationship between ECAP and motor thresholds (ECAPTs and
Birte Elisabeth Dietz, Dave Mugan, Quoc Chi Vuong, Ilona Obara   +3 more
wiley   +1 more source

Gallyas Silver Impregnation of Myelinated Nerve Fibers

Bio-Protocol, 2019
In the nervous system of vertebrates, nerve impulse propagation is accelerated by the ensheathment of neuronal axons with myelin. Myelin sheaths are molecularly specialized, lipid-rich plasma membrane extensions of Schwann cells in the peripheral nervous
Sabitha Joseph, Hauke Werner, Judith Stegmüller   +2 more
doaj   +1 more source

Silicon Nanowire Mats Enable Advanced Bioelectrical Recordings in Primary DRG Cell Cultures

Advanced Healthcare Materials, EarlyView.
SiNW mat‐based MEA (NW_MEA) enables continuous intracellular recordings from neurons in primary rat DRG cell cultures, identifying C‐fiber nociceptors. Supported by an astrocyte feeder layer, SiNW mat promotes DRG neuron and glial cell growth, preserving in vivo‐like cell characteristics and allowing drug‐modulated activity monitoring.
Ivano Lucarini, Francesco Maita, Giorgia Conte, Emanuela Saracino, Francesco Formaggio, Elena Palmieri, Roberta Fabbri, Aikaterini Konstantoulaki, Chiara Lazzarini, Marco Caprini, Valentina Benfenati, Luca Maiolo, Annalisa Convertino   +12 more
wiley   +1 more source

Derivation of a bidomain model for bundles of myelinated axons [PDF]

arXiv, 2022
The work concerns the multiscale modeling of a nerve fascicle of myelinated axons. We present a rigorous derivation of a macroscopic bidomain model describing the behavior of the electric potential in the fascicle based on the FitzHugh-Nagumo membrane dynamics.
arxiv  

Nanoscale correlated disorder in out-of-equilibrium myelin ultrastructure [PDF]

ACS Nano 12(1), 729-739 (2018), 2017
Ultrastructural fluctuations at nanoscale are fundamental to assess properties and functionalities of advanced out-of-equilibrium materials. We have taken myelin as a model of supramolecular assembly in out-of-equilibrium living matter. Myelin sheath is a simple stable multi-lamellar structure of high relevance and impact in biomedicine. Although it is
arxiv   +1 more source