Results 131 to 140 of about 2,055,689 (405)

Nerve growth factor in the equine joint [PDF]

, 2021
Nerve growth factor (NGF) is a neurotrophin with many functions. In humans, it is involved in inflammation, nerve growth, apoptosis and pain signalling.
Ekman, Stina, Hansson, E., Hulten, Lm, Kendall, Anna, Lindahl, A., Nystrom, S., Skiöldebrand, Eva   +6 more
core  

The Generalized Persistent Nerve Theorem [PDF]

arXiv, 2018
In this paper a parameterized generalization of a good cover filtration is introduced called an {\epsilon}-good cover, defined as a cover filtration in which the reduced homology groups of the image of the inclusions between the intersections of the cover filtration at two scales {\epsilon} apart are trivial.
arxiv  

Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open‐Label, Phase 1 Trial

Arthritis Care &Research, EarlyView.
Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner, Anna Shmagel, Gerd Horneff, Ivan Foeldvari, Jordi Antón, Athimalaipet V. Ramanan, Yuli Qian, Kristina Unnebrink, Shuai Hao, Heidi S. Camp, Nasser Khan, Wei Liu, Mohamed‐Eslam F. Mohamed   +12 more
wiley   +1 more source

Neurotrophic factor changes in the rat thick skin following chronic constriction injury of the sciatic nerve

Molecular Pain, 2012
Background Cutaneous peripheral neuropathies have been associated with changes of the sensory fiber innervation in the dermis and epidermis. These changes are mediated in part by the increase in local expression of trophic factors.
Peleshok Jennifer C, Ribeiro-da-Silva Alfredo   +1 more
doaj   +1 more source

NGF2002: more powerful than NGF1951 [PDF]

, 2002
In 1951, Rita Levi-Montalcini discovered nerve growth-stimulating factor, later named nerve growth factor (NGF), which today is recognized as the paradigm of a whole family of neurotrophic proteins, the neurotrophins.
Chaldakov, George N.
core   +2 more sources

Self-Supervised Representation Learning for Nerve Fiber Distribution Patterns in 3D-PLI [PDF]

A comprehensive understanding of the organizational principles in the human brain requires, among other factors, well-quantifiable descriptors of nerve fiber architecture. Three-dimensional polarized light imaging (3D-PLI) is a microscopic imaging technique that enables insights into the fine-grained organization of myelinated nerve fibers with high ...
arxiv   +1 more source

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor(*)

Journal of Biological Chemistry, 1995
The mitogen-activated protein kinase (MAP kinase) pathway is thought to play an important role in the actions of neurotrophins. A small molecule inhibitor of the upstream kinase activator of MAP kinase, MAP kinase kinase (MEK) was examined for its effect
L. Pang, T. Sawada, S. Decker, A. Saltiel   +3 more
semanticscholar   +1 more source

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source

Heterogeneity‐induced NGF‐NGFR communication inefficiency promotes mitotic spindle disorganization in exhausted T cells through PREX1 suppression to impair the anti‐tumor immunotherapy with PD‐1 mAb in hepatocellular carcinoma

Cancer Medicine
Background The mechanism of decreased T cells infiltrating tumor tissues in hepatocellular carcinoma is poorly understood. Methods Cells were separated from the single‐cell RNA‐sequence dataset of hepatocellular carcinoma patients (GSE149614) for cell ...
Xin Wang, Tongwang Yang, Shangheng Shi, Chuanshen Xu, Feng Wang, Deshu Dai, Ge Guan, Yong Zhang, Shuxian Wang, Jianhong Wang, Bingliang Zhang, Peng Liu, Xiaoshuai Bai, Yan Jin, Xinqiang Li, Cunle Zhu, Dexi Chen, Qingguo Xu, Yuan Guo   +18 more
doaj   +1 more source

Adipose-Derived Stem Cells Stimulate Regeneration of Peripheral Nerves: BDNF Secreted by These Cells Promotes Nerve Healing and Axon Growth De Novo [PDF]

, 2011
Transplantation of adipose-derived mesenchymal stem cells (ASCs) induces tissue regeneration by accelerating the growth of blood vessels and nerve. However, mechanisms by which they accelerate the growth of nerve fibers are only partially understood.
A Batistatou, A Efimenko, A Passaniti, AG Lau, Alexander Revischin, C Mantovani, Christophe Egles, DM McDonald, Dmitry Stambolsky, DO Traktuev, EY Lee, Galina Pavlova, GW Plant, IV Vard'ya, J Rehman, JD Guest, JR Bain, K Rubina, K Rubina, Kseniya Rubina, L Cai, L Decker, M Koda, Maxim Karagyaur, MN Kah-Hui Wong, N Billon, N Inagaki, N Mellios, Natalia Kalinina, O Jahn, OP Balezina, OP Balezina, PA Zuk, PJ Kingham, Q Yuan, R Curtis, S Walsh, T Fuhrmann, T Fuhrmann, Tatiana Lopatina, Vsevolod Tkachuk, WM Yu, X Wei, X Wei, XM Zhang, Y Honma, Y Xu, Y Yuan, Yelena Parfyonova   +48 more
core   +2 more sources