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Nerve growth factor therapy for corneal disease
Current Opinion in Ophthalmology, 2012Purpose of review To review the experimental and clinical data on the effects of nerve growth factor (NGF) in corneal physiopathology and to discuss the future development of NGF therapy for corneal diseases.
A. Lambiase, M. Sacchetti, S. Bonini
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New England Journal of Medicine, 2010
Osteoarthritis, a common, painful condition, occurs at a rate of 1% per year and affects the majority of people who are over 55 years of age. In a proof-of-concept, phase 2 study in this issue of the Journal, Lane and colleagues1 report that blocking the activity of nerve growth factor with a neutralizing humanized monoclonal antibody (tanezumab) can ...
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Osteoarthritis, a common, painful condition, occurs at a rate of 1% per year and affects the majority of people who are over 55 years of age. In a proof-of-concept, phase 2 study in this issue of the Journal, Lane and colleagues1 report that blocking the activity of nerve growth factor with a neutralizing humanized monoclonal antibody (tanezumab) can ...
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1980
Nerve growth factor (NGF) is an insulin-like protein, which regulates growth, development and maintenance of sympathetic and embryonic sensory neurons. It is found in varying amounts in the venom of all tested poisonous snakes and in the male mouse submaxillary gland.
Roger Y. Andres, Ralph A. Bradshaw
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Nerve growth factor (NGF) is an insulin-like protein, which regulates growth, development and maintenance of sympathetic and embryonic sensory neurons. It is found in varying amounts in the venom of all tested poisonous snakes and in the male mouse submaxillary gland.
Roger Y. Andres, Ralph A. Bradshaw
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A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.
Science, 1987Nerve growth factor (NGF) is a trophic agent that promotes the outgrowth of nerve fibers from sympathetic and sensory ganglia. The neuronal differentiation stimulated by this hormone was examined in the NGF-responsive cell line PC12.
J. Milbrandt
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Receptors for Nerve Growth Factor
1993Publisher Summary This chapter discusses the two receptors for nerve growth factor (NGF)—namely, (1) the low-affinity NGF receptor and (2) the product of the proto-oncogene trk . It also reviews the way they were originally identified and the structural and functional features of the two receptors.
David S. Battleman +2 more
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Biochemistry, 1986
Pheochromocytoma (PC12) cells have been found to differ from dorsal root ganglionic cells with respect to the modulation of the beta nerve growth factor (beta NGF) binding properties elicited by alpha NGF and gamma NGF. In contrast to our previous results with intact dorsal root ganglionic cells in which only high-affinity binding was blocked, alpha ...
Kenneth E. Neet, Nathaniel R. Woodruff
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Pheochromocytoma (PC12) cells have been found to differ from dorsal root ganglionic cells with respect to the modulation of the beta nerve growth factor (beta NGF) binding properties elicited by alpha NGF and gamma NGF. In contrast to our previous results with intact dorsal root ganglionic cells in which only high-affinity binding was blocked, alpha ...
Kenneth E. Neet, Nathaniel R. Woodruff
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1987
Beta-nerve growth factor (s-NGF) is a polypeptide of 118 amino acids, and is a member of the group of polypeptide growth factors (PGF) that includes epidermal growth factor (EGF), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and several other growth factors (see Table 1).
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Beta-nerve growth factor (s-NGF) is a polypeptide of 118 amino acids, and is a member of the group of polypeptide growth factors (PGF) that includes epidermal growth factor (EGF), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and several other growth factors (see Table 1).
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Nerve growth factor and the neostriatum
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19911. The present review summarizes evidence describing the expression, immunoreactivity, binding, transport, development, aging, and functions of NGF in the mammalian neostriatum. 2. Neostriatal NGF binding sites and intrinsic cholinergic neurons are co-localized, increase at a similar rate during ontogeny, and are lost to an equal extent following age ...
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1990
The discovery of nerve growth factor (NGF) nearly 4 decades ago and the research that followed have had a profound impact upon our understanding of neurotrophic factors and neuronal survival and development. The requirement of NGF by selective neuronal populations implies that many other neurotrophic factors are functioning in the nervous system.
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The discovery of nerve growth factor (NGF) nearly 4 decades ago and the research that followed have had a profound impact upon our understanding of neurotrophic factors and neuronal survival and development. The requirement of NGF by selective neuronal populations implies that many other neurotrophic factors are functioning in the nervous system.
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