Results 71 to 80 of about 1,892,908 (403)

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

A ‘Relay’-Type Drug-Eluting Nerve Guide Conduit: Computational Fluid Dynamics Modeling of the Drug Eluting Efficiency of Various Drug Release Systems

Pharmaceutics, 2022
Nerve guidance conduits (NGCs) are tubular scaffolds that act as a bridge between the proximal and distal ends of the native nerve to facilitate the nerve regeneration.
Jiarui Zhou, Sanjairaj Vijayavenkataraman   +1 more
doaj   +1 more source

The statistical mechanics of complex signaling networks : nerve growth factor signaling

, 2004
It is becoming increasingly appreciated that the signal transduction systems used by eukaryotic cells to achieve a variety of essential responses represent highly complex networks rather than simple linear pathways. While significant effort is being made
Arkin A, Brown K S, Brown K S Sethna J P, Chen K C, Fletcher R, Goldbeter A, Greene L A, Hastings W K, Kirkpatrick S, Laub M T, Marquardt D W, Metropolis N, Newman M E J, Press W H, Robert C P, Stryer L, Traverse S   +16 more
core   +1 more source

Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis" [PDF]

, 2015
The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of ...
IANNITELLI, ANGELA, Quartini, Adele, Tirassa, Paola   +2 more
core   +2 more sources

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Morphofunctional regeneration by mesenchymal stem cell and IGF-1 inoculation in a model of facial nerve crush injury in rats

Brazilian Journal of Otorhinolaryngology, 2023
Objective: To analyze the morphofunctional regeneration process of facial nerve injury in the presence of insulin-like growth factor-1 and mesenchymal stem cells.
Aracele Gonçalves Vieira, Fausto Pierdona Guzen, José Rodolfo Lopes de Paiva, Lucídio Clebeson de Oliveira, Maria Clara de Araújo Jales, Eudes Euler de Souza Lucena, Virgínia Raquel dos Santos Lucena, Hécio Henrique Araújo de Morais   +7 more
doaj  

Human umbilical cord mesenchymal stem cells promote peripheral nerve repair via paracrine mechanisms

Neural Regeneration Research, 2015
Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent a promising young-state stem cell source for cell-based therapy. hUCMSC transplantation into the transected sciatic nerve promotes axonal regeneration and functional recovery.
Zhi-yuan Guo, Xun Sun, Xiao-long Xu, Jiang Peng, Yu Wang   +4 more
doaj   +1 more source

Potential application of let-7a antagomir in injured peripheral nerve regeneration

Neural Regeneration Research, 2023
Neurotrophic factors, particularly nerve growth factor, enhance neuronal regeneration. However, the in vivo applications of nerve growth factor are largely limited by its intrinsic disadvantages, such as its short biological half-life, its contribution ...
Qian-Qian Chen, Qian-Yan Liu, Pan Wang, Tian-Mei Qian, Xing-Hui Wang, Sheng Yi, Shi-Ying Li   +6 more
doaj   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

Assessing the itching intensity using visual analogue scales in atopic dermatitis patients against the background of a therapy with calcineurin inhibitors

Vestnik Dermatologii i Venerologii, 2017
Goal. To assess the effect of topical treatment of atopic dermatitis patients with the 0.1% tacrolimus ointment on the itching intensity and skin expression level of growth factor proteins affecting the intensity of cutaneous innervation.
V. V. Chikin, V. A. Smolyannikova, D. V. Proshutinskaya, M. A. Nefedova   +3 more
doaj   +1 more source