Results 71 to 80 of about 2,134,725 (245)

A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury. [PDF]

, 2016
The p75 neurotrophin receptor is important in multiple physiological actions including neuronal survival and neurite outgrowth during development, and after central nervous system injury.
Alam, Antoine, Arnone, Michele, Baroni, Marco, Beattie, Michael S, Bono, Françoise, Bresnahan, Jacqueline C, Canolle, Benoit, Castel, Marie-Noelle, Delbary-Gossart, Sandrine, Delesque-Touchard, Nathalie, Ferguson, Adam R, Ferzaz, Badia, Herbert, Jean-Marc, Laboudie, Patricia, Lamarche, Isabelle, Lee, Sangmi, Lin, Amity, Manley, Geoffrey T, Sacramento, Jeffrey, Salegio, Ernesto A, Savi, Pierre   +20 more
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The statistical mechanics of complex signaling networks : nerve growth factor signaling

, 2004
It is becoming increasingly appreciated that the signal transduction systems used by eukaryotic cells to achieve a variety of essential responses represent highly complex networks rather than simple linear pathways. While significant effort is being made
Arkin A, Brown K S, Brown K S Sethna J P, Chen K C, Fletcher R, Goldbeter A, Greene L A, Hastings W K, Kirkpatrick S, Laub M T, Marquardt D W, Metropolis N, Newman M E J, Press W H, Robert C P, Stryer L, Traverse S   +16 more
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Extracellular vesicle-induced differentiation of neural stem progenitor cells [PDF]

, 2019
Neural stem progenitor cells (NSPCs) from E13.5 mouse embryos can be maintained in culture under proliferating conditions. Upon growth-factor removal, they may differentiate toward either neuronal or glial phenotypes or both.
Biagioni, S., Cacci, E., Cardarelli, S., Conti, R., Poiana, G., Stronati, E.   +5 more
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Prediction of relative change in free nerve growth factor following subcutaneous administration of tanezumab, a novel monoclonal antibody to nerve growth factor

CPT: Pharmacometrics & Systems Pharmacology, 2023
Tanezumab is a monoclonal antibody against nerve growth factor (NGF). We investigated tanezumab pharmacokinetic (PK)‐NGF relationships and predicted the extent of systemic free NGF suppression with target‐mediated drug disposition (TMDD) modeling using ...
Satoshi Shoji, Akiyuki Suzuki, Parya Nouri, Chun‐Hua Cai, Puneet Gaitonde, Scott Marshall   +5 more
doaj   +1 more source

Molecular examination of bone marrow stromal cells and chondroitinase ABC-assisted acellular nerve allograft for peripheral nerve regeneration [PDF]

, 2016
The present study aimed to evaluate the molecular mechanisms underlying combinatorial bone marrow stromal cell (BMSC) transplantation and chondroitinase ABC (Ch-ABC) therapy in a model of acellular nerve allograft (ANA) repair of the sciatic nerve gap ...
Deng, Lingxiao, Guan, Li-Xin, Jia, Hua, Li, Wen-Yuan, Liu, Gui-Bo, Liu, Yan-Cui, Wang, Ying   +6 more
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Leukemia Inhibitory Factor Augments Neurotrophin Expression and Corticospinal Axon Growth after Adult CNS Injury [PDF]

, 1999
The cytokine leukemia inhibitory factor (LIF) modulates glial and neuronal function in development and after peripheral nerve injury, but little is known regarding its role in the injured adult CNS.
Blesch, A., Cheng, J.-G., Grill, R. J., Patterson, P. H., Tuszynski, M. H., Uy, H. S.   +5 more
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Polylactic-co-glycolic acid microspheres containing three neurotrophic factors promote sciatic nerve repair after injury

Neural Regeneration Research, 2015
A variety of neurotrophic factors have been shown to repair the damaged peripheral nerve. However, in clinical practice, nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor are all peptides or proteins that may be rapidly ...
Qun Zhao, Zhi-yue Li, Ze-peng Zhang, Zhou-yun Mo, Shi-jie Chen, Si-yu Xiang, Qing-shan Zhang, Min Xue   +7 more
doaj   +1 more source

Urinary Biomarkers Under Investigation for Overactive Bladder Syndrome [PDF]

, 2015
Overactive bladder (OAB) is a symptom syndrome of urinary urgency, frequency, nocturia, and urge incontinence suggestive of lower urinary tract dysfunction.
Guirguis, Nayera, Heit, Michael
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Neuroprotective effects of ultrasound-guided nerve growth factor injections after sciatic nerve injury

Neural Regeneration Research, 2015
Nerve growth factor (NGF) plays an important role in promoting neuroregeneration after peripheral nerve injury. However, its effects are limited by its short half-life; it is therefore important to identify an effective mode of administration.
Hong-fei Li, Yi-ru Wang, Hui-ping Huo, Yue-xiang Wang, Jie Tang   +4 more
doaj   +1 more source

Nanofibrous bicomponent scaffolds for the dual delivery of NGF and GDNF: controlled release of growth factors and their biological effects [PDF]

, 2015
Meeting Theme: Driving Biomaterial Innovation and the Race to TranslationINTRODUCTION: Repairing severely injured peripheral nerves requires suitable devices for bridging the gap and guiding axon growth.
Liu, C, Wang, M
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