Results 81 to 90 of about 260,202 (306)

Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain

, 2017
Xiushuai Shang, Zhaofei Wang, Hairong Tao Department of Orthopedic Surgery, Shanghai Key Laboratory of Orthopedic Implant, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China Abstract: Osteoarthritis
Tao H, Shang X, Wang Z
core  

The Neurosensory Tachykinins Substance P and Neurokinin A Directly Induce Keratinocyte Nerve Growth Factor

, 2001
Nerve growth factor is an essential neurotrophic factor required for the growth and maintenance of cutaneous sensory nerves. In the skin, keratinocytes are a significant source of nerve growth factor; however, the regulation of cutaneous nerve growth ...
Caughman, S. Wright, Ansel, John C., Naik, Shubhada M., Zivony, Adam S., Kim, Amy, Kim, Kyu H., Burbach, Guido J., Aranda, Jennifer, Armstrong, Cheryl A., Wright, Stacey   +9 more
core   +1 more source

Polylactic-co-glycolic acid microspheres containing three neurotrophic factors promote sciatic nerve repair after injury

Neural Regeneration Research, 2015
A variety of neurotrophic factors have been shown to repair the damaged peripheral nerve. However, in clinical practice, nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor are all peptides or proteins that may be rapidly ...
Qun Zhao, Zhi-yue Li, Ze-peng Zhang, Zhou-yun Mo, Shi-jie Chen, Si-yu Xiang, Qing-shan Zhang, Min Xue   +7 more
doaj   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Production of a Monoclonal Antibody Directed against the High-Affinity Nerve Growth Factor Receptor

The International Journal of Biological Markers, 1999
The high-affinity nerve growth factor receptor corresponds to the tyrosine protein kinase encoded by the proto-oncogene trkA. Different findings suggest that nerve growth factor (NGF) can be operative in the growth modulation of tumor cell lines ...
E. Tagliabue, C. Ghirelli, L. Lombardi, F. Castiglioni, L. Asnaghi, C. Longhi, M.G Borrello, P. Aiello, S. Ménard   +8 more
doaj   +1 more source

Neuroprotective effects of ultrasound-guided nerve growth factor injections after sciatic nerve injury

Neural Regeneration Research, 2015
Nerve growth factor (NGF) plays an important role in promoting neuroregeneration after peripheral nerve injury. However, its effects are limited by its short half-life; it is therefore important to identify an effective mode of administration.
Hong-fei Li, Yi-ru Wang, Hui-ping Huo, Yue-xiang Wang, Jie Tang   +4 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Nerve growth factor delivery by ultrasound-mediated nanobubble destruction as a treatment for acute spinal cord injury in rats

, 2017
Zhaojun Song,1 Zhigang Wang,2 Jieliang Shen,1 Shengxi Xu,1 Zhenming Hu1 1Department of Orthopedics, The First Affiliated Hospital, 2Institution of Ultrasound Imaging, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People&rsquo ...
Shen J, Hu Z, Xu S, Wang Z, Song Z
core  

Heterogeneity‐induced NGF‐NGFR communication inefficiency promotes mitotic spindle disorganization in exhausted T cells through PREX1 suppression to impair the anti‐tumor immunotherapy with PD‐1 mAb in hepatocellular carcinoma

Cancer Medicine
Background The mechanism of decreased T cells infiltrating tumor tissues in hepatocellular carcinoma is poorly understood. Methods Cells were separated from the single‐cell RNA‐sequence dataset of hepatocellular carcinoma patients (GSE149614) for cell ...
Xin Wang, Tongwang Yang, Shangheng Shi, Chuanshen Xu, Feng Wang, Deshu Dai, Ge Guan, Yong Zhang, Shuxian Wang, Jianhong Wang, Bingliang Zhang, Peng Liu, Xiaoshuai Bai, Yan Jin, Xinqiang Li, Cunle Zhu, Dexi Chen, Qingguo Xu, Yuan Guo   +18 more
doaj   +1 more source