Results 51 to 60 of about 1,720,901 (357)

Effect of mechanical stimulation on tissue heterotopic ossification: an in vivo experimental study

Frontiers in Physiology, 2023
Background: Heterotopic ossification of tendons and ligaments (HOTL) is a common clinical condition characterized by the absence of discernible features and a lack of effective treatment. In vitro experiments have demonstrated that mechanical stimulation
Zhengya Zhu, Zhengya Zhu, Zhongyuan He, Zhongyuan He, Tao Tang, Tao Tang, Fuan Wang, Fuan Wang, Hongkun Chen, Jiaxiang Zhou, Chengkai Lin, Guoliang Chen, Jianmin Wang, Jianfeng Li, Xizhe Liu, Zhiyu Zhou, Zhiyu Zhou, Shaoyu Liu, Shaoyu Liu   +18 more
doaj   +1 more source

Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2, and cytoskeletal remodeling in Schwann cells [PDF]

, 2018
Schwann cells are key players in neuro-regeneration: They sense "alarm" signals released by degenerating nerve terminals and differentiate toward a proregenerative phenotype, with phagocytosis of nerve debris and nerve guidance.
Duregotti, E, Gerke, V, Marchioretto, M, Montecucco, C, Negro, S, Quattrone, A, Rigoni, M, Rodella, U, Stazi, Marco, Tebaldi, T, Viero, G   +10 more
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Combination of Adult Mesenchymal Stem Cell Therapy and Immunomodulation with Dimethyl Fumarate Following Spinal Cord Ventral Root Repair

Biology
Spinal cord injury results in significant motor and sensory loss. In the experimental ventral root avulsion (VRA) model, the ventral (motor) roots are disconnected from the spinal cord surface, disrupting contact between spinal motoneurons and muscle ...
Paula Regina Gelinski Kempe, Mateus Vidigal de Castro, Lilian de Oliveira Coser, Luciana Politti Cartarozzi, Benedito Barraviera, Rui Seabra Ferreira, Alexandre Leite Rodrigues de Oliveira   +6 more
doaj   +1 more source

TRPV1 agonist, capsaicin, induces axon outgrowth after injury via Ca2+/PKA signaling [PDF]

, 2018
Preconditioning nerve injuries activate a pro-regenerative program that enhances axon regeneration for most classes of sensory neurons. However, nociceptive sensory neurons and central nervous system neurons regenerate poorly.
DiAntonio, Aaron, Frey, Erin, Karney-Grobe, Scott, Krolak, Trevor, Milbrandt, Jeff   +4 more
core   +2 more sources

Flow Cytometry Characterization and Analysis of Glial and Immune Cells from the Spinal Cord

Neuroglia
Several protocols have been developed with the aim of characterizing glial and immune cells from the central and peripheral nervous systems. However, a small number of these protocols have demonstrated the ability to yield satisfactory results following ...
Lilian de Oliveira Coser, Manuela Tosi Comelis, Débora Elisa da Costa Matoso, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira   +4 more
doaj   +1 more source

Neuropeptides Involved in Facial Nerve Regeneration

Biomedicines, 2021
Neuropeptides and neurotransmitters act as intermediaries to transmit impulses from one neuron to another via a synapse. These neuropeptides are also related to nerve degeneration and regeneration during nerve damage.
Inhyeok Kim, Yonjae Kim, Daewoong Kang, Junyang Jung, Sungsoo Kim, Hwasung Rim, Sanghoon Kim, Seung-Geun Yeo   +7 more
doaj   +1 more source

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush. [PDF]

, 2014
Peripheral nerve regeneration following injury occurs spontaneously, but many of the processes require metabolic energy. The mechanism of energy supply to axons has not previously been determined.
Farah, M.H., Jin, L., Lee, Y., Lengacher, S., Magistretti, P.J., Morrison, B.M., Pellerin, L., Rothstein, J.D., Tsingalia, A., Vidensky, S.   +9 more
core   +1 more source

Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function

Frontiers in Cell and Developmental Biology, 2020
Alpha-Synuclein (αSyn), a protein highly enriched in neurons where it preferentially localizes at the pre-synapse, has been in the spotlight because its intraneuronal aggregation is a central phenomenon in Parkinson’s disease.
Marina I. Oliveira da Silva, Marina I. Oliveira da Silva, Márcia A. Liz   +2 more
doaj   +1 more source

DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling

JOR Spine, 2023
Background Ossification of the posterior longitudinal ligaments (OPLL) is common disorder characterized by heterotopic ossification of the spinal ligaments. Mechanical stimulation (MS) plays an important role in OPLL.
Tao Tang, Zhengya Zhu, Zhongyuan He, Fuan Wang, Hongkun Chen, Shengkai Liu, Mingbin Zhan, Jianmin Wang, Wei Tian, Dafu Chen, Xinbao Wu, Xizhe Liu, Zhiyu Zhou, Shaoyu Liu   +13 more
doaj   +1 more source

Neuroscience of Peripheral Nerve Regeneration

Journal of Pharmacy and Bioallied Sciences, 2021
Peripheral nerve injury involves complex molecular, cellular, and genetic events that help in ultimate regeneration of nerve. Some key factors are upregulated and some downregulated in the process of regeneration of nerve to attain almost perfect architecture.
Sunil Paramel Mohan, Murugan Ramalingam
openaire   +3 more sources