Results 31 to 40 of about 1,942,100 (397)
Frontiers in Molecular Biosciences, 2023 Background: Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, and an overall understanding of the molecular mechanisms related to IDD is still lacking. The purpose of this study was to explore gene signatures and immune cell
Tao Tang +17 more
doaj +1 more source
Cyclic AMP Signaling: A Molecular Determinant of Peripheral Nerve Regeneration [PDF]
, 2014 Disruption of axonal integrity during injury to the peripheral nerve system (PNS) sets into motion a cascade of responses that includes inflammation, Schwann cell mobilization, and the degeneration of the nerve fibers distal to the injury site.
Assi, Mazen +2 more
core +3 more sources
Plastic and Reconstructive Surgery, 2022 Background: Ideal nerve repair involves tensionless direct repair, which may not be possible after resection. Bridging materials include nerve autograft, allograft, or conduit.
Jonathan Lans +5 more
semanticscholar +1 more source
BMC Chemistry, 2023 As an essential marker of cancer treatment, PARP-1 inhibitors could effectively kill tumor cells through a mechanism known as synthetic lethality and are used to treat a variety of cancers.
Ling Yu +6 more
doaj +1 more source
The effect of vascular graft and human umbilical cord blood-derived CD34+ stem cell on peripheral nerve healing [PDF]
, 2018 AIM: There are many trials concerning peripheral nerve damage causes and treatment options. Unfortunately, nerve damage is still a major problem regarding health, social and economic issues.
Abban, G. +6 more
core +1 more source
Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit
Frontiers in Bioengineering and Biotechnology, 2019 Peripheral nerve repair and regeneration remains among the greatest challenges in tissue engineering and regenerative medicine. Even though peripheral nerve injuries (PNIs) are capable of some degree of regeneration, frail recovery is seen even when the ...
Cristiana R. Carvalho +2 more
semanticscholar +1 more source
The potential of Antheraea pernyi silk for spinal cord repair [PDF]
, 2017 This work was supported by the Institute of Medical Sciences of the University of Aberdeen, Scottish Rugby Union and RS McDonald Charitable Trust. We are grateful to Mr Nicholas Hawkins from Oxford University and Ms Annette Raffan from the University of ...
Huang, W +5 more
core +2 more sources
Strategies for Peripheral Nerve Repair
Current Tissue Microenvironment Reports, 2020 This review focuses on biomechanical and cellular considerations required for development of biomaterials and engineered tissues suitable for implantation following PNI, as well as translational requirements relating to outcome measurements for testing ...
M. Wilcox +4 more
semanticscholar +1 more source
Differential Gene Expression in Primary Cultured Sensory and Motor Nerve Fibroblasts
Frontiers in Neuroscience, 2019 Fibroblasts (Fbs) effectively promote Schwann cells (SCs) migration, proliferation, and neurite regeneration. Whether Fbs express different motor and sensory phenotypes that regulate the cell behavior and peripheral nerve function has not been elucidated.
Qianru He +6 more
doaj +1 more source
A variable neurodegenerative phenotype with polymerase gamma mutation [PDF]
, 2009 mtDNA replication and repair, causes mitochondrial diseases including autosomal dominant progressive external ophthalmoplegia (PEO),1 childhood hepato-encephalopathy (Alpers– Huttenlocher syndrome), adult-onset spinocerebellar ataxia, and sensory nerve
Baruffini, E. +8 more
core +1 more source