Results 11 to 20 of about 375,080 (241)

Transection injury differentially alters the proteome of the human sural nerve

open access: yesPLoS ONE, 2022
Regeneration after severe peripheral nerve injury is often poor. Knowledge of human nerve regeneration and the growth microenvironment is greatly lacking.
Monica J. Chau   +7 more
doaj   +2 more sources

Using a Transection Paradigm to Enhance the Repair Mechanisms of an Investigational Human Cell Therapy

open access: yesCell Transplantation, 2022
One promising strategy in cell therapies for Parkinson’s disease (PD) is to harness a patient’s own cells to provide neuroprotection in areas of the brain affected by neurodegeneration. No treatment exists to replace cells in the brain.
Monica J. Chau   +6 more
doaj   +1 more source

Nerve damage induced skeletal muscle atrophy is associated with increased accumulation of intramuscular glucose and polyol pathway intermediates [PDF]

open access: yes, 2020
Perturbations in skeletal muscle metabolism have been reported for a variety of neuromuscular diseases. However, the role of metabolism after constriction injury to a nerve and the associated muscle atrophy is unclear.
Afzal, Shoaib   +3 more
core   +2 more sources

Induction of ectopic retina-like tissue by transgenic expression of neurogenin. [PDF]

open access: yesPLoS ONE, 2015
Degeneration of retinal neurons is an underlying cause of several major types of blinding diseases, and effective therapies remain to be developed. The suppositive strategy of repopulating a degenerative retina with new cells generated onsite faces ...
Run-Tao Yan   +3 more
doaj   +1 more source

Cell-free therapy based on extracellular vesicles: a promising therapeutic strategy for peripheral nerve injury

open access: yesStem Cell Research & Therapy, 2023
Peripheral nerve injury (PNI) is one of the public health concerns that can result in a loss of sensory or motor function in the areas in which injured and non-injured nerves come together.
Mojdeh Salehi Namini   +6 more
doaj   +1 more source

Collagen‐rich deposit formation in the sciatic nerve after injury and surgical repair: A study of collagen‐producing cells in a rabbit model

open access: yesBrain and Behavior, 2020
Introduction Posttraumatic scarring of peripheral nerves produces unwanted adhesions that block axonal growth. In the context of surgical nerve repair, the organization of the scar tissue adjacent to conduits used to span the gap between the stumps of ...
Jolanta Fertala   +5 more
doaj   +1 more source

Spike Generators and Cell Signaling in the Human Auditory Nerve: An Ultrastructural, Super-Resolution, and Gene Hybridization Study

open access: yesFrontiers in Cellular Neuroscience, 2021
Background: The human auditory nerve contains 30,000 nerve fibers (NFs) that relay complex speech information to the brain with spectacular acuity. How speech is coded and influenced by various conditions is not known.
Wei Liu   +10 more
doaj   +1 more source

Skin cornification proteins provide global link between ROS detoxification and cell migration during wound healing. [PDF]

open access: yesPLoS ONE, 2010
Wound healing is a complex dynamic process characterised by a uniform flow of events in nearly all types of tissue damage, from a small skin scratch to myocardial infarction.
Wilbert P Vermeij, Claude Backendorf
doaj   +1 more source

EMSCs‐Seeded Micro‐Stripe Patterned Polycaprolactone Promoting Sciatic Nerve Regeneration

open access: yesAdvanced Materials Interfaces, 2023
Transplantation of a synthetic polymer nerve conduit carrying stem cells is promising for treating peripheral nerve injury. In this study, a micropatterned inner surface of polycaprolactone (PCL) nerve conduit cellularized with nasal respiratory mucosa ...
Naiyan Lu   +10 more
doaj   +1 more source

A Bioinspired Self‐Healing Conductive Hydrogel Promoting Peripheral Nerve Regeneration

open access: yesAdvanced Science, 2023
The development of self‐healing conductive hydrogels is critical in electroactive nerve tissue engineering. Typical conductive materials such as polypyrrole (PPy) are commonly used to fabricate artificial nerve conduits.
Hongyun Xuan   +8 more
doaj   +1 more source

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