Results 91 to 100 of about 2,682,635 (296)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

A novel method of lengthening the accessory nerve for direct coaptation during nerve repair and nerve transfer procedures

, 2018
OBJECTIVEThe accessory nerve is frequently repaired or used for nerve transfer. The length of accessory nerve available is often insufficient or marginal (under tension) for allowing direct coaptation during nerve repair or nerve transfer (neurotization),
Rong Li, Li, Rong, Fries, Fabian N, Loukas, Marios, Rod J. Oskouian, Fabian N. Fries, R. Shane Tubbs, Oskouian, Rod J, Maldonado, Andrés A, Marios Loukas, Spinner, Robert J, Yolanda Stoves, Tubbs, R Shane, Robert J. Spinner, Andrés A. Maldonado, Stoves, Yolanda   +15 more
core   +2 more sources

Chapter 28 future perspective in peripheral nerve reconstruction.

, 2009
Nerve injuries induce severe disability and suffering for patients. Profound alterations in nerve trunks, neurons, and the central nervous system are induced rapidly after injury.
Dahlin, Lars, Martin Kanje, Lars Dahlin, Charlotta Lindwall, Lindwall, Charlotta, Fredrik Johansson, Kanje, Martin, Lindwall, Charlotta,, Johansson, Fredrik, Dahlin, Lars,, Johansson, Fredrik,, Lund University.   +11 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Clinical outcomes of elbow flexion reconstruction using ulnar nerve fascicle transfer versus intercostal nerve transfer in indication-based brachial plexus injury groups

Egyptian Journal of Neurosurgery
Introduction Restoring elbow flexion is a primary goal in brachial plexus injury (BPI) reconstruction, as it is crucial for daily function. Ulnar nerve fascicle transfer and intercostal nerve (ICN) transfer are common surgical options.
Rama Dhanianda Siregar, Aga Shahri Putera Ketaren, Muhammad Hidayat Siregar   +2 more
doaj   +1 more source

Outcome of contralateral C7 nerve transferring to median nerve

Chinese Medical Journal, 2013
Background Contralateral C7 (cC7) transfer had been widely used in many organizations in the world, but the outcomes were significantly different. So the purpose of the study was to evaluate the outcome of patients treated with cC7 transferring to median nerve and to determine the factors affecting the outcome of this procedure.
Kai-ming, Gao, Jie, Lao, Xin, Zhao, Yu-dong, Gu   +3 more
openaire   +2 more sources

Optic nerve hypoplasia in the fetal alcohol syndrome:a mouse model [PDF]

, 1995
Optic nerve hypoplasia is commonly observed in children affected by the fetal alcohol syndrome, and is believed to contribute to their poor visual acuity.
Dhillon, Baljean, Parson, S H, Findlater, G S, Kaufman, M H   +3 more
core  

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source